TUBB2B Gene Microcephaly Genetic Test in UAE | 2800 AED | DHA Licensed

Name: TUBB2B Gene Microcephaly Genetic Test
Brand: DNA Labs UAE
SKU: DX-LAB-2541
Price: 2800 AED
Availability: InStock

Executive Summary & Core Metrics

Core Diagnostic Overview

This definitive next-generation sequencing (NGS) assay deciphers the TUBB2B gene – the master regulator of cortical neurogenesis – with 99.9% diagnostic sensitivity for primary microcephaly. Priced at 2800 AED, the test is performed under ISO 9001:2015 certified protocols (Cert: INT/EGQ/2509DA/3139) and includes expert genetic counselling aligned with DHA standards and UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.

Premium Logistics: VIP mobile phlebotomy and temperature-controlled home collection across UAE (daily 8 AM – 11 PM).
Clinical Guidance: Complimentary post-test tele-counselling with a DHA-licensed consultant medical geneticist to interpret results.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.

Test Overview & Methodology

The TUBB2B gene encodes beta-tubulin, an essential protein for neuronal migration and cortical folding. Pathogenic variants lead to autosomal dominant primary microcephaly with variable dysmorphology. Our NGS approach replaces legacy Sanger sequencing by enabling simultaneous detection of single-nucleotide variants, indels, and copy number changes in a single workflow.

Feature	Our Test (DNA Labs UAE)	Closest Alternative (Sanger TUBB2B)
Methodology	NGS – 300× mean coverage, full gene analysis	Sanger sequencing – selected exons only
Sensitivity	99.9% for SNVs & CNVs	~95% (misses large rearrangements)
Turnaround Time	3–4 weeks	4–6 weeks
Sample Requirement	Whole blood (preferred), extracted DNA, or FTA card (1 drop)	Whole blood only

Physician Insight & Safety Protocols

“The TUBB2B NGS test provides a robust molecular diagnosis for primary microcephaly, but the clinical context—neurodevelopmental milestones, brain imaging, family history—remains essential. A negative result does not exclude other genetic or syndromic causes. Our genetic counselling team integrates these findings into a personalised care plan. Patients should not alter any prescribed medication or therapy without consulting their managing physician.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Advisory on Informed Consent & Genetic Testing

Critical Safety Notice & Exclusion Criteria

Minors: Testing of individuals under 18 requires legal guardian consent and pre-test counselling in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Exclusion: Recent blood transfusion (wait ≥ 2 weeks) or inability to provide informed consent.
Emergency Red Flags: If the tested individual develops new-onset seizures, apnea, or unexplained loss of consciousness, seek emergency care immediately—these are not side effects of the test but may signal evolving neuropathology.
This test is not a substitute for comprehensive dysmorphology evaluation or neuroimaging.

Pre-Test Logistics & Medication Advisory

Medication Advisory

No fasting is required. A mandatory genetic counselling session to draw a detailed pedigree chart of family members affected with TUBB2B-related microcephaly is required before sample collection. Provide a complete clinical history of the proband. No routine medication or supplement avoidance is required; however, inform the genetic counsellor of all current treatments for contextual interpretation.

Patient FAQ & Clinical Guidance

1. What is the TUBB2B gene and how does it cause microcephaly?

The TUBB2B gene provides instructions for making beta-tubulin, a protein essential for neuronal migration and cortical architecture; pathogenic mutations disrupt these processes, leading to primary microcephaly with variable dysmorphic features. Because the defect occurs early in fetal brain development, head circumference is significantly reduced at birth and may be accompanied by developmental delays. Our NGS test reads the entire coding region to identify even rare, previously unreported variants.

2. How accurate is this NGS test compared to other genetic tests for microcephaly?

With a diagnostic sensitivity of 99.9% for both sequence variants and copy-number alterations, our NGS panel outperforms single-gene Sanger sequencing, which misses large deletions and has a lower analytical sensitivity. The test achieves clinical-grade accuracy by 300× sequencing depth and orthogonal confirmation of all pathogenic findings. Results are interpreted according to ACMG/AMP guidelines, ensuring the highest reliability.

3. What does a positive result mean for my child’s health and future family planning?

A positive result confirms a molecular diagnosis of TUBB2B-related microcephaly, guiding prognosis, targeted surveillance (e.g., for seizures or motor deficits), and recurrence risk counselling for future pregnancies. Because the condition is inherited in an autosomal dominant manner, the risk of passing the variant to the next child is up to 50% if a parent carries the same mutation. Genetic counselling will provide personalised recurrence estimates and discuss prenatal/preimplantation genetic testing options.

UAE Regulatory & Data Privacy Adherence

This genetic test is conducted in full compliance with:

Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring the confidentiality and security of genetic information.
Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing the electronic handling of health data.
Federal Decree-Law No. 4 of 2016 on Medical Liability – establishing standards for informed consent and clinical responsibility.
All laboratory procedures are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).

Clinical & Logistical Metadata

Test Name	TUBB2B Gene Microcephaly Genetic Test
Price (AED)	2,800 AED
Turnaround Time	3–4 weeks
Sample Type / Matrix	Whole blood, extracted DNA, or FTA card (1 drop)
Methodology Used	Next-Generation Sequencing (NGS) – 300× coverage
ICD-10-CM Code	Q02 (Microcephaly)
LOINC Code	91868-9 (DNA sequencing of TUBB2B gene)
DHA Facility License & Laboratory Address	DHA Facility License Number: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab Branding: DNA Labs UAE