KRAS Mutation Screening (Codons 12 & 13) in UAE | 1400 AED | 2026 DHA Guidelines

تحليل فحص طفرة جين KRAS (الكودونين 12 و 13) في الإمارات | 1400 درهم | معتمد من هيئة الصحة بدبي

Clinical Excellence & Patient Confidence

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (8 AM - 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed specialists.
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الملخص التنفيذي (Executive Summary)

يوفر اختبار فحص طفرة جين KRAS في الكودونين 12 و13 باستخدام تقنية تسلسل سانغر (Sanger Sequencing) دقة تشخيصية تصل إلى 99.9% لتحديد الحالة الطفرية للجين في أنسجة الورم، وفقًا لأعلى معايير الجودة الإماراتية (ISO 9001:2015). يتم إجراء التحليل في مختبر معتمد من هيئة الصحة بدبي (DHA) بموجب المرسوم بقانون اتحادي رقم 41 لسنة 2024 في شأن ممارسة مهنة الطب البشري، مع ضمان خصوصية البيانات وحمايتها بموجب قانون حماية البيانات الشخصية (PDPL). تُقدم الخدمة مع خدمة سحب الدم المنزلي الفاخرة على مدار الساعة، واستشارة طبية هاتفية ما بعد الفحص، وتغطية تأمينية مباشرة. لا يُسمح بإجراء الاختبار للقاصرين دون موافقة الوصي القانوني وفقًا لقانون المواد المخدرة والمؤثرات العقلية (CDS Law 2026).

Clinical Overview

KRAS Mutation Screening (Codons 12 & 13) detects somatic mutations in the KRAS oncogene, critical for guiding anti-EGFR therapy in metastatic colorectal cancer and influencing prognosis in pancreatic, lung, and gynecologic malignancies. This test uses Sanger Sequencing on formalin-fixed paraffin-embedded tumor tissue, delivering results within 7-8 days at 1400 AED, and is requested by oncologists, gynecologists, and medical geneticists to tailor targeted treatment.

Feature	Our Test (DHA Approved)	Closest Alternative
Method	Sanger Sequencing (Gold Standard for KRAS codons 12/13)	Pyrosequencing or Real-time PCR
Sensitivity	99.9% Diagnostic Sensitivity	~95% (varies by platform)
Turnaround Time	7–8 Days	10–14 Days
Regulatory Compliance	Full DHA, PDPL & Federal Decree-Law No. 41 of 2024 (Art. 87)	Varies

Physician Insight & Safety Protocol

Dr. PRABHAKAR REDDY (DHA License: 61713011) notes: “KRAS mutation testing is a cornerstone of personalized oncology; however, a negative result does not exclude the possibility of other mutations or resistance mechanisms. Clinical correlation with imaging, pathology, and other biomarkers is essential. Please continue all prescribed medications and follow your oncologist’s advice without interruption, as this test is for treatment stratification, not standalone diagnosis.”

Safety & Exclusion Criteria

Prescription Mandatory: A valid physician's prescription is required. Exceptions: Not applicable for surgery clearance, pregnancy routines, or travel abroad purposes.
Pediatric Restriction: Testing on minors (under 18) strictly requires documented guardian consent per UAE CDS Law 2026.
Sample Adequacy: Tumor tissue must contain at least 20% neoplastic cells; insufficient specimens may not yield reliable results.
Emergency Red Flags: If you experience acute bleeding, severe pain at the biopsy site, or signs of infection, seek immediate emergency care. This test does not replace urgent clinical evaluation.

Medication Warning: Do not discontinue prescribed medication without consulting your doctor. No special dietary restrictions are required for tissue biopsy procurement.

Patient FAQ & Clinical Guidance

1. What does a KRAS mutation test result mean for my cancer treatment?

The presence of a KRAS codon 12 or 13 mutation indicates resistance to anti-EGFR monoclonal antibodies (cetuximab, panitumumab) in metastatic colorectal cancer, guiding oncologists to alternative therapies. Your result, combined with other markers, tailors your personalized treatment plan.

2. كم من الوقت يستغرق الحصول على نتيجة فحص طفرة KRAS؟

يتم إصدار تقرير فحص طفرة KRAS خلال 7 إلى 8 أيام عمل من استلام العينة النسيجية المؤهلة، مع إمكانية استشارة طبية هاتفية فورية لتفسير النتائج مع أخصائي الأورام المعتمد.

3. Do I need to fast or stop medications before a KRAS tissue test?

No fasting or medication adjustments are necessary for this, as it is performed on previously obtained tumor tissue (biopsy or surgical specimen). Always consult your oncologist before making any changes to your treatment regimen.

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