Test Price
2,800 AED✅ Home Collection Available
PCCB Gene Propionic Acidemia Genetic Test in UAE – 2,800 AED – NGS Sequencing
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited next-generation sequencing with Sanger confirmation.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Post-test telephonic interpretation and family counselling referral by a consultant medical geneticist.
- Insurance Verification: Direct billing confirmation via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The PCCB gene NGS test interrogates all coding exons and exon-intron boundaries of the PCCB gene to identify pathogenic variants causative of Propionic Acidemia, an autosomal recessive inborn error of metabolism. Full-gene coverage includes single nucleotide variants, small insertions and deletions, and copy number variations, with orthogonal Sanger sequencing confirmation for every reported variant.
| Feature | Our PCCB NGS Test | Standard Metabolic Panel |
|---|---|---|
| Sequencing Technology | NGS full-gene coverage + MLPA and Sanger confirmation of all detected variants | Targeted hotspot panel; deep intronic and structural variants may be missed |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Diagnostic Yield | 99.9% sensitivity for PCCB coding, splice-site, and selected deep intronic variants | Approximately 95% sensitivity; reflex testing frequently required |
| Post-Test Support | Complimentary telephonic clinical guidance and referral for family counselling | Not routinely included |
Physician Insight & Safety Protocols
A definitive molecular diagnosis can be a profound step for a family living with the uncertainty of a metabolic disorder. I encourage you to view this test as a precise tool, not a standalone verdict — clinical correlation alongside a specialist metabolic physician is essential. Your genetic counsellor will interpret these results within your unique medical and family history, ensuring the path forward is clear and supported.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice – Medication and Dietary Stability
Do not discontinue any prescribed medication or modify your child’s dietary therapy without consulting your specialist metabolic physician. This test provides genetic verification but does not replace acute clinical management.
Exclusion Criteria & Emergency Red Flags
- Not indicated for asymptomatic population screening without a positive family history or clinical suspicion.
- Individuals who have received an allogeneic bone marrow transplant within the last 6 weeks may yield false-negative results.
- Patients under 18 years require consent through a legal guardian in compliance with UAE personal data protection regulations.
- Emergency Red Flags: If the child develops vomiting, lethargy, hypotonia, or seizures, seek immediate emergency care — do not wait for genetic test results.
Patient FAQ & Clinical Guidance
1. What does the PCCB gene test detect?
The test detects mutations in the PCCB gene causing Propionic Acidemia, a condition impairing the breakdown of certain amino acids and odd-chain fatty acids. This comprehensive NGS assay covers all exons and exon-intron boundaries, identifying single nucleotide variants, small deletions and insertions, and copy number variations that disrupt propionyl-CoA carboxylase activity.
2. Who should consider this test?
Individuals with clinical symptoms, abnormal newborn screening results, or a family history of Propionic Acidemia should consider this test; it is also essential for carrier screening before pregnancy. The test is equally valuable for at-risk relatives seeking clarity and for couples planning a family to assess recurrence risk.
3. How should I prepare for the blood draw?
No fasting is required; simply schedule our complimentary mobile phlebotomy visit, ensuring you remain hydrated and report any medications to our clinical team. Our certified phlebotomist will collect a small blood sample in the comfort of your home, maintaining strict cold-chain conditions throughout transport to our ISO-accredited laboratory.
4. How are results delivered and interpreted?
Results are issued as a detailed PDF report within 3 to 4 weeks from sample receipt. A consultant medical geneticist provides a complimentary telephonic interpretation session to explain findings, discuss implications for family members, and coordinate referral for metabolic specialist follow-up if indicated.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
This laboratory service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed within UAE jurisdiction using encrypted transmission and secure storage infrastructure. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. ISO 9001:2015 Certification: INT/EGQ/2509DA/3139.
DHA Facility License Number: 1143
Clinical & Logistical Metadata
| Test Name | PCCB Gene Propionic Acidemia Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | E71.121 |
| LOINC Code | 94498-7 |
| DHA Facility License & Laboratory Address | DHA License: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians