Test Price
2,800 AEDโ Home Collection Available
LCT Gene Congenital Lactase Deficiency NGS Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189:2022 Accredited Clinical Genomics Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Post-Test Telephonic Interpretation & Genetic Counseling by Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Price: 2800 AED (includes lab processing, bioinformatics analysis, and clinical report).
- Turnaround Time: 3โ4 Weeks from sample receipt at laboratory.
Test Overview & Methodology
This Next Generation Sequencing (NGS) based genetic test analyzes the LCT gene for pathogenic and likely pathogenic variants causing congenital lactase deficiency (CLD). The test provides definitive molecular diagnosis for newborns, infants, and children presenting with severe lactose intolerance, refractory diarrhea, and failure to thrive. Results empower immediate dietary interventions and long-term nutritional planning under specialist supervision.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | NGS 99.9% Diagnostic Sensitivity | Sanger Sequencing (lower variant coverage) |
| Method | Next Generation Sequencing (NGS) | Single-Gene PCR / Sanger |
| Turnaround Time | 3โ4 Weeks | 4โ6 Weeks |
| Sample Requirement | Whole blood / Extracted DNA / FTA card droplet | Blood only; no FTA card option |
Physician Insight & Safety Protocols
"Molecular confirmation of congenital lactase deficiency via NGS provides the cornerstone for targeted nutritional management and prevention of growth faltering. Nonetheless, findings must be correlated with clinical presentation and functional tests, as carrier states and benign polymorphisms may occasionally require clarification through segregation analysis."
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Reg: 9294403
Advisory Notice
Do not discontinue prescribed lactose-free formula or medications without explicit instruction from your managing pediatrician or gastroenterologist. This genetic test does not replace acute care or symptomatic management of severe dehydration or electrolyte imbalance.
Exclusion Criteria & ER Red Flags
- Acute metabolic decompensation (severe vomiting, hypoglycemia, hypotonia) requires emergency stabilization before sample collection.
- Infants under 2 weeks old must be hemodynamically stable; home collection only after pediatrician clearance.
- Recent blood transfusion (within 4 weeks) may affect DNA purity; reschedule collection after recommended interval.
- Patients with known bone marrow transplant history require alternative tissue sampling (buccal swab or extracted DNA from pre-transplant archived material).
Patient FAQ & Clinical Guidance
1. What exactly does the LCT gene congenital lactase deficiency NGS test detect?
Brief Answer: This high-resolution sequencing test identifies pathogenic DNA variants in the LCT gene responsible for congenital lactase-phlorizin hydrolase deficiency, enabling definitive molecular classification and informed dietary planning.
2. How is the sample collected and what specimen types are acceptable?
Brief Answer: We accept whole blood (3โ5 mL in EDTA), extracted DNA (minimum 1 ยตg), or a single blood spot on an FTA card. Collection is performed via our temperature-controlled VIP Mobile Phlebotomy service from 8 AM to 11 PM daily.
3. Why is genetic counseling recommended before and after this test?
Brief Answer: Pre-test counseling ensures understanding of autosomal recessive inheritance, recurrence risks, and implications for family members. Post-test counseling clarifies variant interpretation, penetrance, and long-term surveillance recommendations.
4. What is the difference between congenital lactase deficiency and acquired lactose intolerance?
Brief Answer: Congenital lactase deficiency is a rare autosomal recessive disorder presenting in newborns with severe diarrhea upon lactose exposure, while acquired intolerance is common in older children and adults due to lactase non-persistence โ a different genetic mechanism involving the MCM6 regulatory region.
UAE Regulatory & Data Privacy Adherence
This clinical service is delivered in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed within UAE-based secure servers. Patient consent, including specific authorization for genetic analysis and data handling, is obtained prior to sample collection in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. Your health information is used solely for diagnostic purposes and is never shared with third parties without explicit written consent.
Clinical & Logistical Metadata
| Test Name | LCT Gene Congenital Lactase Deficiency NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks (21โ28 calendar days) |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card blood spot |
| Methodology Used | Next Generation Sequencing (NGS) โ Full coding region & splice sites of LCT gene |
| ICD-10-CM Code | E73.0 |
| LOINC Code | 94026-6 |
| DHA Facility License & Address | DNA Labs UAE | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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