Test Price
2,800 AED✅ Home Collection Available
DBT Gene (Maple Syrup Urine Disease Type 2) Genetic Test in UAE | 2800 AED | DHA Approved
Executive Summary & Core Metrics
Clinical-Grade Genetic Certainty, Delivered to Your Door
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing, utilizing Next-Generation Sequencing (NGS) with >99% analytical sensitivity and specificity for single nucleotide variants and small indels in the DBT gene. This eliminates diagnostic doubt for Maple Syrup Urine Disease Type 2.
Premium Logistics: Complimentary, hospital-grade cold-chain home collection by certified phlebotomists (8 AM – 11 PM) across all Emirates. Blood, extracted DNA, or one-drop FTA card samples accepted with rigorous chain-of-custody.
Clinical Guidance: Every report includes a complimentary telephonic post-test interpretation session with a senior clinical geneticist to contextualize results, discuss cascade screening, and outline metabolic management pathways.
Insurance & Billing: Direct verification via WhatsApp: +971 54 548 8731. Premium coverage for family history, neonatal suspicion, and premarital screening.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test analyzes the entire coding region of the dihydrolipoamide branched-chain transacylase (DBT) gene, responsible for Maple Syrup Urine Disease Type 2 (MSUD II) — a severe autosomal recessive inborn error of metabolism. The assay is designed for definitive molecular diagnosis in symptomatic neonates, pre-symptomatic sibling screening, and accurate carrier detection in consanguineous UAE populations where prevalence is elevated.
| Parameter | Our Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% sensitivity for SNVs/indels | Often limited to hotspot panels |
| Method | Full NGS + ACMG 2026 ML Interpretation | Sanger sequencing (gene subsets) |
| Speed | 3–4 Weeks (urgent infant option) | Often 6–8 Weeks |
Physician Insight & Safety Protocols
“A positive DBT mutation confirms MSUD Type 2 but must be correlated with plasma amino acids and urine organic acids; an early, aggressive low-branched-chain amino acid diet can achieve normal neurodevelopmental outcomes. I urge families to partner with a metabolic specialist from the moment a positive newborn screen is received.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA License: 9294403
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Recent blood transfusion (< 2 weeks) may cause donor DNA contamination; bone marrow transplant recipients require alternative sample source (buccal swab). Not validated for large deletion/duplication detection unless paired with MLPA.
- ER Red Flags: If the patient develops vomiting, lethargy, neurological deterioration, or maple syrup odor to urine/cerumen, seek emergency medical attention immediately. Do not wait for genetic results.
- Consent Note: Written informed consent and genetic counseling are mandatory prior to sample collection per Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What does the DBT gene test detect and how soon can I get results?
This test identifies disease-causing variants in the entire DBT gene through next-generation sequencing, delivering a comprehensive molecular report in 3 to 4 weeks. It reveals point mutations and small insertions/deletions that cause Maple Syrup Urine Disease Type 2, enabling precise diagnosis even when symptoms are subtle.
2. Is home sample collection safe for my newborn, and is it included in the 2800 AED?
Absolutely, pediatric-trained phlebotomists visit your home with ISO-certified cold-chain kits, and the collection fee is fully included in the 2800 AED price. For infants, a heel-prick dried blood spot (FTA card) is accepted, minimizing discomfort while preserving DNA integrity for high-quality sequencing.
3. Will insurance cover this genetic test if my child is symptomatic?
Direct insurance billing is confirmed instantly via WhatsApp at +971545488731; most UAE policies cover medically indicated genetic testing with a physician's referral. Our team handles pre-authorizations for diagnostic suspicion of MSUD, positive newborn screening, or family history, ensuring minimal out-of-pocket cost.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance
This service operates under the strict framework of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is encrypted and processed within UAE borders, ensuring full compliance with local health information governance. The laboratory holds DHA Facility License No. 1143 and follows international standards for genetic testing and reporting.
Clinical & Logistical Metadata
| Test Name | DBT Gene (Maple Syrup Urine Disease Type 2) Genetic Sequencing |
| Price (AED) | 2,800 AED (All-Inclusive) |
| Turnaround Time | 3–4 Weeks (urgent infant option available) |
| Sample Type / Matrix | Peripheral Blood (Whole Blood, EDTA), Extracted DNA, or FTA Card (Dried Blood Spot) |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene coding regions + ACMG variant interpretation |
| ICD-10-CM Code | E71.0 |
| LOINC Code | 21648-5 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians