Test Price
1,800 AED✅ Home Collection Available
Advanced Inborn Errors of Metabolism Extended Panel in UAE
Executive Summary & Core Metrics
Precision Diagnostic Overview
The Advanced IEM Extended Panel analyzes over 100 metabolic analytes in blood and urine using tandem mass spectrometry and GC-MS, delivering a definitive biochemical phenotype for suspected inborn errors of metabolism. This panel is the gold standard for differential diagnosis in neonatal screening, unexplained developmental delay, and adult-onset metabolic crisis.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection, available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance for result interpretation with our genetics consultant.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced panel utilizes tandem mass spectrometry to quantitatively measure minute concentrations of specific amino acids, acylcarnitines, and organic acids that accumulate due to inherited enzyme deficiencies, detecting over 60 treatable conditions including Phenylketonuria, Maple Syrup Urine Disease, and Medium-Chain Acyl-CoA Dehydrogenase deficiency. These disorders remain invisible on standard chemistry panels, making this comprehensive analysis essential for accurate diagnosis.
| Feature | Advanced IEM Extended Panel | Standard Newborn Screen |
|---|---|---|
| Analytical Method | Tandem Mass Spectrometry (TMS) + GC/MS + Enzyme Assay | Tandem Mass Spectrometry (TMS) only |
| Diagnostic Coverage | 100+ analytes; Amino acids, acylcarnitines, organic acids, purines/pyrimidines | ~40 core analytes; limited to acylcarnitine and amino acid profiles |
| Clinical Utility | Diagnostic confirmation, differential diagnosis for all ages, functional medicine insights | Primarily a first-tier screening tool for newborns |
| Report Turnaround | 3 Days | 5-10 Days |
Physician Insight & Safety Protocols
"Interpreting an extended metabolic panel requires deep clinical correlation; a mildly elevated C5-OH acylcarnitine could be a transient finding or signify a life-threatening organic aciduria. As a consultant medical geneticist, I integrate this biochemical fingerprint with the patient's growth trajectory, feeding history, and neurological examination—never relying on a single value in isolation. My commitment is to demystify these complex pathways and guide families toward the most effective, evidence-based intervention."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Critical Medication Advisory
Do not discontinue, adjust, or pause any prescribed medication, including anti-epileptic drugs such as valproic acid or carnitine supplements, prior to this test without explicit consultation with your managing physician. Abrupt changes can precipitate a metabolic crisis or severe clinical deterioration.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion for Home Collection: Infants or adults currently in an acute metabolic crisis with encephalopathy, intractable vomiting, or severe hypoglycemia require immediate hospital-based emergency care, not a scheduled home draw.
- ER Red Flags: If the patient develops lethargy, tachypnea, seizures, or loss of consciousness after sample collection, proceed immediately to the nearest emergency department and inform the ER physician that metabolic testing is pending.
Patient FAQ & Clinical Guidance
1. What exactly does the Extended IEM Panel detect that a regular blood test cannot?
This advanced panel uses tandem mass spectrometry to measure minute concentrations of specific amino acids, acylcarnitines, and organic acids that accumulate due to inherited enzyme deficiencies, detecting over 60 treatable conditions like Phenylketonuria, Maple Syrup Urine Disease, and Medium-Chain Acyl-CoA Dehydrogenase deficiency. These conditions are invisible on standard chemistry panels.
2. My newborn already had a heel-prick test; why is this comprehensive panel necessary for my older child?
Newborn screening is a high-sensitivity rapid test designed to catch a specific subset of severe early-onset forms of IEM. This diagnostic-grade extended panel maps the full biochemical pathway, identifying milder variants, late-onset presentations, and disorders like X-linked Adrenoleukodystrophy or Lysosomal Storage Diseases that manifest later in childhood with developmental regression or behavioral changes.
3. How should I prepare my child for the blood and urine collection to ensure accurate results?
Accurate diagnosis requires collecting dried blood spots and urine while the child is metabolically stressed, ideally after a brief fasting period of 4-6 hours as tolerated, and before administering emergency medications. Complete documentation of all dietary formulas, supplements, and drug history must accompany the sample to our ISO-certified laboratory.
4. When will I receive the results and how are they communicated?
Results are typically available within 3 business days from sample receipt at our laboratory. A comprehensive clinical report is delivered electronically via secure portal, followed by a complimentary telephonic consultation with our genetics team to explain findings and guide next steps.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework
All personal data and health information processed during this diagnostic service are handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE maintains ISO 9001:2015 accreditation (Cert: INT/EGQ/2509DA/3139) ensuring the highest standards of quality management and data security.
Your genomic and metabolic data are encrypted, access-restricted, and never shared with third parties without explicit written consent. We uphold the UAE's commitment to patient confidentiality and biomedical ethics.
Clinical & Logistical Metadata
| Test Name | Advanced Inborn Errors of Metabolism (IEM) Extended Panel |
| Price (AED) | 1,800 AED |
| Turnaround Time | 3 Business Days |
| Sample Type / Matrix | Blood (Dried Blood Spot, Serum, Plasma) and Random Urine |
| Methodology Used | Tandem Mass Spectrometry (LC-MS/MS), Gas Chromatography/Mass Spectrometry (GC/MS), Enzyme Assay |
| ICD-10-CM Code | E70.0, E71.1, Z13.228 |
| LOINC Code | 49289-7 |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE DNA Labs UAE |
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