Test Price
450 AED✅ Home Collection Available
Uroplakin III Immunohistochemistry Test in UAE | 450 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Lab (Cert: INT/EGQ/2509DA/3139).
- Specimen Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval – FFPE blocks or formalin‑fixed tissue collected from histopathology departments.
- Clinical Guidance: Telephonic Post‑Test Interpretation support by DHA‑licensed pathologists. Direct WhatsApp access at +971 54 548 8731.
- Insurance: Instant Direct Billing Verification via WhatsApp. We handle approvals with all major UAE insurers.
Test Overview & Methodology
Uroplakin III Immunohistochemistry (IHC) is a specialized diagnostic assay that detects uroplakin III protein expression in tumor tissue sections. This test confirms urothelial carcinoma lineage, differentiates primary bladder malignancies from metastatic lesions, and supports targeted therapy selection for patients with genitourinary cancers.
The assay employs validated monoclonal antibodies on an automated IHC staining platform using formalin‑fixed paraffin‑embedded (FFPE) tissue blocks. Interpretation is performed by board‑certified pathologists who correlate staining intensity, distribution, and cellular localization with histomorphology.
Comparative Performance
| Feature | Uroplakin III IHC | Conventional H&E |
|---|---|---|
| Lineage Specificity | High (urothelial origin) | Low (morphology only) |
| Methodology | IHC on FFPE tissue | Routine histochemical stain |
| Turnaround Time | 5–7 working days | 1–2 days (limited) |
Physician Insight & Safety Protocols
Mr. Prabhakar Reddy Kalathoor | Specialist Diagnostic Radiology | DHA Registration ID: 61713011
“A positive Uroplakin III IHC result provides strong evidence for urothelial differentiation, yet it must always be interpreted alongside histologic architecture, clinical history, and imaging findings. The managing oncologist should integrate this data into the complete diagnostic picture before any treatment decision.”
Clinical Advisory & Follow‑up Guidance
Important Clinical Considerations
A confirmatory IHC result does not replace comprehensive oncologic evaluation. Patients must continue all prescribed therapies unless explicitly directed by their treating physician. Self‑interpretation of pathology reports is strongly discouraged.
Exclusion Criteria & Red Flags
- Inadequate or necrotic tumor tissue; specimens fixed in non‑standard formalin solutions may be rejected.
- Missing histopathology report, biopsy site designation, or clinical history – mandatory for valid interpretation.
- Specimen transported without temperature‑controlled cold chain may compromise antigen integrity.
- Seek emergency care immediately if: sudden severe hematuria, acute flank pain, urinary obstruction, or uncontrollable bleeding develops.
Patient FAQ & Clinical Guidance
1. What is the Uroplakin III IHC test used for?
This test detects uroplakin III protein expression in tumor tissue to confirm a diagnosis of urothelial carcinoma and guide targeted therapy decisions for patients with bladder cancer.
2. How should the tissue sample be prepared and sent?
Submit tumor tissue as a formalin‑fixed paraffin‑embedded (FFPE) block or a formalin‑fixed tissue section in 10% neutral buffered formalin. Include the original histopathology report, biopsy site designation, and relevant clinical history.
3. Can I arrange home collection for my tissue sample?
This test requires an archival solid tissue specimen (FFPE block or formalin‑fixed tissue). Our Secure Medical Courier Solid Tissue Specimen Retrieval service collects from hospitals and clinics; mobile phlebotomy is not applicable for this specimen type.
4. How long does it take to get results?
The turnaround time is 5–7 working days from receipt of the tissue specimen in the laboratory. Results are delivered electronically and can be accessed via patient portal.
UAE Regulatory & Data Privacy Adherence
All diagnostic services at DNA Labs UAE operate in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient health information is encrypted, access‑controlled, and processed solely for diagnostic purposes. Clinical safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory holds DHA Facility License No. 1143, issued by the Dubai Health Authority, and follows all applicable standards for immunohistochemistry testing.
Clinical & Logistical Metadata
| Test Name | Uroplakin III Immunohistochemistry (IHC) |
| Price (AED) | 450 AED |
| Turnaround Time | 5–7 Working Days |
| Sample Type / Matrix | Formalin‑Fixed Paraffin‑Embedded (FFPE) Tissue Block or Formalin‑Fixed Tissue Section |
| Methodology Used | Immunohistochemistry (IHC) – Automated Staining Platform with Monoclonal Antibody |
| ICD-10-CM Code | C67.9, C67.0–C67.8, C68.8 |
| LOINC Code | 21945-9 |
| DHA Facility License & Laboratory Address | License No: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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