Test Price
450 AED✅ Home Collection Available
SOX-11 Immunohistochemistry (IHC) Test in UAE | 450 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% specificity for mantle cell lymphoma detection using monoclonal anti-SOX-11 (clone MRQ-58) on automated Ventana Benchmark platform.
- Specimen Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval – archival FFPE blocks or fresh biopsies accepted daily until 6 PM.
- Clinical Oversight: Post-test telephonic interpretation by DHA-licensed diagnostic radiology specialist.
- Insurance Support: Direct billing verification via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
The SOX-11 Immunohistochemistry (IHC) test is a targeted diagnostic assay that detects nuclear SOX-11 protein expression in formalin-fixed paraffin-embedded (FFPE) tissue sections. This biomarker is highly specific for mantle cell lymphoma (MCL) and reliably identifies cyclin D1-negative MCL variants that evade standard B-cell panels. The methodology employs polymer-based detection chemistry validated against in-situ hybridization (ISH) and polymerase chain reaction (PCR) gold standards.
| Feature | SOX-11 IHC Test | Standard IHC Panel |
|---|---|---|
| Precision | 99.9% specificity via automated Ventana Benchmark platform with clone MRQ-58 | Lower specificity for cyclin D1-negative MCL (CD5, Cyclin D1, CD20 panel) |
| Method | Polymer-based detection validated against ISH and PCR gold standards | Conventional IHC without single-marker SOX-11 reflex testing |
| Turnaround | 5 working days for FFPE block; 7 days for large/complex specimens | 7-10 working days due to sequential multi-marker staining protocol |
Physician Insight & Safety Protocols
"SOX-11 immunostaining provides a decisive diagnostic anchor in challenging B-cell lymphoma classifications, particularly when cyclin D1 expression is equivocal or absent. This single-marker assay complements morphology and clinical history to refine therapeutic stratification. Oncologists should interpret the result within a multidisciplinary framework that includes Ki-67 proliferation index and PET-CT staging."
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Advisory Notes for Referring Clinicians
Clinical Exclusion Criteria & Urgent Referral Indicators
- Insufficient tissue: Core biopsy less than 1 mm or necrotic material requires recollect after clinical reassessment.
- Recent cytotoxic therapy: Specimen collected within 14 days of chemotherapy may exhibit altered antigenicity – reschedule per oncologist.
- Pregnancy: Procedure is safe but consult maternal-fetal medicine for biopsy timing.
- Emergency red flags: Rapidly enlarging lymphadenopathy, unexplained fever exceeding 38.5°C, drenching night sweats, or unintentional weight loss over 10% within 6 months – refer for immediate medical evaluation.
Safety & Medication Stability
Medication Continuity Advisory
Do not discontinue prescribed medications without consulting your treating physician.
All pharmacologic adjustments must be supervised by a qualified medical practitioner. The SOX-11 IHC result does not independently mandate changes to existing therapy regimens.
Patient FAQ & Clinical Guidance
1. What is the SOX-11 Immunohistochemistry test and why is it ordered?
This test identifies SOX-11 protein expression in lymphoma tissue to confirm mantle cell lymphoma (MCL) and guide targeted therapy decisions. It is requested by oncologists when a lymph node biopsy indicates a B-cell neoplasm, particularly if initial immunophenotyping results are ambiguous for cyclin D1. The result distinguishes aggressive MCL variants that may require intensified chemoimmunotherapy regimens incorporating BTK inhibitors.
2. How should I prepare for this test and what documents are needed?
No fasting or medication changes are required. Provide the histopathology report, exact biopsy site, and a concise clinical summary. The laboratory requires the original pathology report, precise anatomical location of the tissue biopsy, and relevant clinical history to ensure accurate pre-analytical handling of the FFPE block or fresh specimen in 10% neutral-buffered formalin.
3. What does a positive SOX-11 result mean for my treatment plan?
A positive SOX-11 result strongly supports a diagnosis of mantle cell lymphoma, often necessitating intensive chemoimmunotherapy combined with targeted agents. It classifies the lymphoma as the blastoid or pleomorphic subtype when cyclin D1 is negative, directing your oncologist toward regimens such as R-CHOP or R-DHAP along with BTK inhibitors. The result is interpreted alongside Ki-67 index, PET-CT findings, and molecular testing to design a personalized treatment strategy.
4. How is the tissue specimen collected and transported?
Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. The tissue biopsy or archival FFPE block is retrieved by our Secure Medical Courier Solid Tissue Specimen Retrieval service, ensuring temperature-controlled chain-of-custody from the collection site to the laboratory.
5. What is the turnaround time for results and how will I receive them?
Results are available within 5 working days for FFPE blocks and up to 7 working days for large or complex tissue specimens. Reports are delivered electronically to your referring physician through our secure clinical portal. A telephonic consultation with a DHA-licensed specialist is provided to discuss the clinical implications of the result.
UAE Regulatory & Data Privacy Adherence
Data Protection Framework: All patient data is processed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Quality Certification: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). All immunohistochemistry procedures follow stringent internal quality controls with external proficiency testing participation.
Clinical & Logistical Metadata
| Test Name | SOX-11 Immunohistochemistry (IHC) Test |
| Price (AED) | 450 AED |
| Turnaround Time | 5-7 Working Days |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block or Fresh Tumor Biopsy in 10% Neutral-Buffered Formalin |
| Methodology Used | Immunohistochemistry (IHC) – Automated Ventana Benchmark Ultra Platform, Monoclonal Anti-SOX-11 Clone MRQ-58, Polymer-Based Detection |
| ICD-10-CM Code | C83.1 (Mantle Cell Lymphoma), C85.80 (Other Specified B-Cell Lymphoma) |
| LOINC Code | 94373-6 (SOX11 [Presence] in Tissue by Immune Stain) |
| DHA Facility License & Laboratory Address | DHA License: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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