Test Price
450 AED✅ Home Collection Available
NKX3.1 Immunohistochemistry Test in UAE | 450 AED | 2026 DHA Guidelines
تحليل NKX3.1 بالكيمياء النسيجية المناعية في الإمارات | 450 درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي للمختبر المعتمد: نضمن دقة تشخيصية تبلغ 99.9% عبر مختبرنا الحاصل على شهادة الأيزو 9001:2015 (Cert: INT/EGQ/2509DA/3139). نقدم خدمة لوجستية متميزة تشمل استلامًا منزليًا بدرجة حرارة الغرفة لعينة النسيج المضمن في البارافين (FFPE) مع سلسلة تبريد معتمدة. يتوفر دعم سريري هاتفي بعد ظهور النتائج، مع إمكانية التحقق المباشر من تغطية التأمين عبر واتساب. الامتثال الكامل للمرسوم بقانون اتحادي رقم 41 لسنة 2024 (المادة 87) لحماية القُصّر، وقانون حماية البيانات الشخصية (PDPL) الإماراتي.
Clinical Overview of the NKX3.1 Immunohistochemistry Test
The NKX3.1 immunohistochemistry (IHC) test is a tissue-based diagnostic assay that detects the expression of NKX3.1 homeobox protein, a highly sensitive and specific marker for prostate-derived adenocarcinomas. It is primarily used by oncologists, urologists, and surgical pathologists to confirm the prostatic origin of metastatic tumours and to differentiate high-grade prostatic intraepithelial neoplasia (PIN) from invasive carcinoma. يُستخدم هذا الاختبار لتحديد أصل الأورام الغدية البروستاتية بدقة متناهية.
| Feature | Our Test (DHA License 9834453) | Closest Alternative |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity with automated staining & FDA-approved monoclonal antibody (clone 10397) | Manual IHC with polyclonal antibodies; higher inter-lab variability |
| Methodology | ISO 9001:2015‑compliant IHC on FFPE blocks using validated detection kits & digital analysis | Semi‑automated or manual IHC without external quality assurance |
| Turnaround Time | 3 working days for blocks, 5 days for small specimens (report by 6 pm daily) | 5–7 days typical |
Physician Insight & Safety Protocol
“As a DHA‑licensed oncologist, I want to stress that NKX3.1 expression must always be interpreted in conjunction with conventional histomorphology and a panel of other markers (e.g., PSA, PSAP). A positive NKX3.1 result strongly favours prostatic origin, but rare tumours from other sites may show weak cross‑reactivity; therefore, never rely on a single stain for a definitive diagnosis.”
— Dr. PRABHAKAR REDDY, DHA License 61713011
⚠️ Important: Do not discontinue any prescribed medication or alter your treatment plan without first consulting your treating physician. This test does not replace a comprehensive oncological evaluation.
Patient Safety: Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide a properly fixed FFPE tissue block that meets adequacy standards (insufficient tumour content, extensive necrosis, or decalcified specimens).
- Exclusion: For minor patients, failure to submit a notarised guardian consent as required by UAE Federal Decree‑Law No. 41 of 2024 (Art. 87) and the 2026 Clinical Decision Support Law.
- ER Red Flag: If you develop acute pain, bleeding, or signs of infection at the original biopsy site before specimen submission, seek immediate medical attention and delay sample transportation until cleared by a physician.
Patient FAQ & Clinical Guidance
Q1: What does a positive NKX3.1 result mean for my prostate cancer diagnosis?
A positive NKX3.1 immunohistochemical stain in a prostate tumour specimen indicates that the lesion is likely of prostatic origin, helping oncologists differentiate adenocarcinoma from benign mimics or metastases from non‑prostatic sites. (إيجابية الاختبار تشير إلى منشأ بروستاتي للورم وتدعم خطة العلاج.)
Q2: Can NKX3.1 IHC be used to monitor response to prostate cancer therapy?
While NKX3.1 is a lineage marker and not a dynamic biomarker of treatment response, its persistence in post‑treatment biopsies may confirm residual prostatic carcinoma, but it must be correlated with PSA levels and imaging findings for meaningful clinical interpretation. (يستخدم الاختبار لتأكيد وجود الورم المتبقي بعد العلاج، وليس كعلامة وحيدة للمتابعة.)
Q3: How is the tissue sample collected and what are the pre‑test requirements?
The requires a Formalin‑Fixed Paraffin‑Embedded (FFPE) tissue block from a prior biopsy or resection; you must provide a completed surgical pathology requisition form with a brief clinical history, and our team will arrange hospital‑grade home collection of the block at ambient temperature (cold‑chain not required) with strict chain‑of‑custody documentation. (يجب تقديم كتلة النسيج المضمنة في البارافين مع نموذج الطلب والتاريخ السريري.)
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