Test Price
450 AED✅ Home Collection Available
Immunohistochemistry TTF-1 (Thyroid Transcription Factor-1) Test in UAE | 450 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited IHC processing and dual-pathologist verification.
- Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval – archival tissue blocks and biopsy slides handled under ISO-certified cold-chain transport. Home phlebotomy is not applicable for this test.
- Clinical Guidance: Complimentary telephonic post-test result interpretation by a DHA-licensed oncology pathologist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731 – instant confirmation.
Test Overview & Methodology
The TTF-1 immunohistochemistry test is a tumour-specific tissue biomarker used to determine the primary origin of adenocarcinomas, predominantly distinguishing lung (non-small cell lung carcinoma) and thyroid malignancies. The assay detects thyroid transcription factor-1 nuclear protein in formalin-fixed paraffin-embedded (FFPE) tissue sections via polymer-based detection and digital image analysis, providing quantitative staining intensity and percentage scores for definitive pathologist interpretation.
| Feature | DNA Labs UAE TTF-1 Test (DHA Accredited) | Closest Alternative (General Lab) |
|---|---|---|
| Methodology | Fully-automated IHC with polymer-based detection & digital image analysis | Manual IHC, may lack digital scoring |
| Turnaround Time | 5–7 working days (FFPE block / tissue) | Often 10–14 days |
| Diagnostic Accuracy | >99% sensitivity, dual-pathologist consensus | Variable, single-reader reporting |
| Patient Support | Post-test clinical guidance call, WhatsApp result tracking | Minimal post-analytical support |
Physician Insight & Safety Protocols
“A positive TTF-1 stain must always be correlated with the complete clinical picture, imaging, and histomorphology. It is a powerful guide, but not a stand-alone diagnosis. I urge patients to discuss their full pathology report with both their oncologist and pathologist to avoid misinterpretation.”
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology | DHA Registration ID: 61713011
Critical Medication Advisory
Do not discontinue, modify, or start any medication (including chemotherapy, thyroid hormone, or targeted therapy) without consulting your treating doctor. This test is a diagnostic aid and does not replace clinical judgement. Always present your full histopathology report to your oncologist before making treatment decisions.
Patient Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed with Home Collection)
- Uncontrolled bleeding disorder or INR >1.5 (if re-biopsy is required).
- Active infection or abscess at the biopsy site.
- Suspected pregnancy (inform the phlebotomist; alternative collection may be advised).
Emergency Red Flags – Seek Immediate Care
- Severe, uncontrolled bleeding or expanding haematoma at the biopsy site.
- Fever >38°C, rapidly spreading redness, or purulent discharge.
- Sudden shortness of breath or chest pain (rare allergic/anaphylactic reaction).
Patient FAQ & Clinical Guidance
1. What is TTF-1 testing and why is it performed?
Snippet-grade answer: TTF-1 test identifies TTF-1 protein in tumor cells, helping diagnose lung and thyroid cancers for precise treatment planning.
TTF-1 (Thyroid Transcription Factor-1) is a nuclear protein detected by immunohistochemistry on biopsy tissue. A positive result strongly suggests a primary lung adenocarcinoma or a thyroid malignancy, while a negative result helps exclude these origins, guiding further molecular testing and therapy selection.
2. How do I prepare for the TTF-1 test?
Snippet-grade answer: No special preparation needed; your doctor will collect tumor tissue during biopsy and provide the histopathology report for testing.
The test is performed on already obtained tissue (formalin-fixed paraffin-embedded block or biopsy). If a fresh biopsy is required, follow your doctor’s pre-procedure instructions. Bring a copy of the histopathology report, biopsy site details, and full clinical history for accurate interpretation.
3. What do TTF-1 test results mean?
Snippet-grade answer: Positive TTF-1 indicates the tumor likely originates from lung (adenocarcinoma) or thyroid, requiring correlation with clinical and imaging findings.
TTF-1 positivity is reported as nuclear staining intensity and percentage. A strong, diffuse positive result is typical of lung adenocarcinoma or differentiated thyroid cancer. Negative TTF-1 suggests other primaries (e.g., squamous cell lung carcinoma, colorectal, breast) and necessitates additional immunohistochemical markers for definitive classification.
UAE Regulatory & Data Privacy Adherence
United Arab Emirates Healthcare Compliance
This diagnostic service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols comply with Federal Decree-Law No. 4 of 2016 on Medical Liability. DHA Facility License No. 1143, certified to ISO 9001:2015. All results are interpreted by DHA-licensed pathologists. Direct billing verification and appointments via WhatsApp +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | Immunohistochemistry TTF-1 (Thyroid Transcription Factor-1) |
| Price (AED) | 450 AED |
| Turnaround Time | 5–7 working days (FFPE block / tissue) |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block or Biopsy Slide – Archival Specimen. Home phlebotomy is disabled; Secure Medical Courier Solid Tissue Specimen Retrieval is used. |
| Methodology Used | Fully-automated IHC with polymer-based detection & digital image analysis |
| ICD-10-CM Code | C34.90 |
| LOINC Code | 72448-5 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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