Test Price
450 AED✅ Home Collection Available
Immunohistochemistry SOX-10 Test in UAE | 450 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary
✔ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015-Accredited Processing (Cert: INT/EGQ/2509DA/3139).
✔ Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval – archival FFPE blocks and slides are collected via temperature-controlled chain from your hospital or clinic. Home phlebotomy is not applicable for this tissue-based assay.
✔ Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by our specialist team.
✔ Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The SOX-10 immunohistochemistry (IHC) test is a highly sensitive diagnostic marker for melanoma, schwannoma, and other neural crest-derived tumors. It assists oncologists and pathologists in confirming tumor lineage and guiding targeted therapy decisions by detecting nuclear SOX-10 protein expression in formalin-fixed, paraffin-embedded (FFPE) tissue sections.
Our validated protocol uses a monoclonal anti-SOX-10 antibody on an automated IHC platform, ensuring reproducible, high-contrast nuclear staining. This method is superior to alternative markers such as HMB-45 for detecting desmoplastic and spindle cell melanoma variants.
| Features | Our SOX-10 IHC Test | Alternative Markers (e.g., HMB-45) |
|---|---|---|
| Precision | High sensitivity for desmoplastic / spindle cell melanoma; superior nuclear staining pattern | Lower sensitivity, may be negative in desmoplastic melanoma; cytoplasmic staining |
| Methodology | Validated SOX-10 monoclonal antibody IHC on automated platform | IHC with HMB-45 or Melan-A, often requiring multiplex panels |
| Turnaround Time | FFPE block: 5 working days; large/complex: 7 working days | Similar, but may be extended when reflex to additional markers |
Physician Insight & Safety Protocols
Mr. Prabhakar Reddy Kalathoor (Specialist Diagnostic Radiology, DHA Registration ID: 61713011) notes: “SOX-10 IHC is a highly specific marker for melanocytic and neural crest differentiation. However, results must be interpreted alongside histomorphology and additional markers to avoid misdiagnosis. A negative SOX-10 does not entirely exclude melanoma, particularly in rare variants. Clinical correlation remains paramount.”
Advisory: Do Not Discontinue Medication
⚠️ Do not discontinue prescribed medication or alter your treatment plan without consulting your doctor. The SOX-10 test is a diagnostic aid, not a therapeutic guide on its own.
Safety & Exclusion Criteria
- Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety.
- Sample must be a formalin-fixed, paraffin-embedded (FFPE) tissue block or unstained slides obtained via prior biopsy or surgical resection performed by a DHA-licensed physician. Self-collected specimens are strictly rejected.
- Exclusion criteria: inadequate tissue quantity, improper fixation, missing accompanying histopathology report, or incomplete clinical history will result in sample rejection.
- ER Red Flags: If you experience uncontrolled bleeding, purulent discharge, or high fever following the biopsy, seek immediate emergency medical attention.
- Minors (under 18) require parental/legal guardian consent and presence during sample collection as per UAE regulatory requirements.
Patient FAQ & Clinical Guidance
1. What does a positive SOX-10 IHC result mean?
A positive result indicates that the tumor cells express SOX-10 protein in the nucleus, strongly suggesting a melanocytic (melanoma) or neural crest origin. This helps oncologists confirm the diagnosis, select appropriate targeted therapies (e.g., BRAF inhibitors if also mutated), and plan follow-up surveillance. However, clinicopathologic correlation with histology and other markers is essential to avoid false positives from benign melanocytic lesions or nerve sheath tumors.
2. Is any special preparation needed before the SOX-10 test?
No special preparation is required for the SOX-10 IHC assay itself. The test is performed on tissue that has already been collected during a diagnostic biopsy or surgery. The sample must be properly fixed in formalin and accompanied by the histopathology report, biopsy site information, and relevant clinical details. Your doctor will manage all preparatory steps related to the biopsy procedure.
3. How long does it take to get my SOX-10 result in the UAE?
Results are typically available within 5 working days from the date the FFPE block sample is received at our laboratory. For large or complex specimens requiring additional processing or ancillary studies, the turnaround time may extend to 7 working days. Same-day reporting is not available due to the meticulous nature of immunohistochemical staining and mandatory quality control checks.
UAE Regulatory & Data Privacy Adherence
Your Data, Your Rights
All laboratory data, including immunohistochemistry results and personal medical information, are processed in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our DHA-licensed facility (License No. 1143) ensures that every step from tissue receipt to result delivery meets the highest regulatory standards for confidentiality and integrity.
Clinical & Logistical Metadata
| Test Name | Immunohistochemistry SOX-10 (SOX-10 IHC) |
| Price (AED) | 450 |
| Turnaround Time | 5 working days (FFPE block); 7 working days for large/complex specimens |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block or Unstained Slides |
| Methodology Used | Immunohistochemistry (IHC) with validated SOX-10 monoclonal antibody on automated platform |
| ICD-10-CM Code | C43.9 |
| LOINC Code | 104414-2 |
| DHA Facility License & Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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