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450 AED

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Immunohistochemistry Myeloperoxidase (MPO) Test in UAE | 450 AED | 2026 DHA Guidelines

تحليل كيمياء الأنسجة المناعية للميلوبيروكسيديز (MPO) في الإمارات | 450 درهم | معتمد من هيئة الصحة بدبي

DHA-Licensed Pathology | ISO 9001:2015

Executive Summary & Clinical Promise

  • Accuracy Guarantee 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited immunohistochemistry processing.
    ضمان الدقة: حساسية تشخيصية بنسبة 99.9% عبر معالجة كيميائية مناعية معتمدة وفق معيار ISO.
  • Premium Home Collection Hospital‑grade mobile phlebotomy and biopsy transport with ISO‑certified cold‑chain logistics, 8 AM–11 PM (subject to pre‑authorisation).
  • Clinical Guidance Post‑test telephonic interpretation session with a DHA‑licensed pathologist.
    إرشادات سريرية: جلسة تفسير هاتفية بعد النتيجة مع أخصائي أمراض مرخص من هيئة الصحة بدبي.
  • Insurance & Billing Direct insurance verification via WhatsApp at +971 54 548 8731 — instant pre‑approval for most major UAE networks.

Overview & Clinical Utility

The Immunohistochemistry (IHC) Myeloperoxidase (MPO) test detects the MPO enzyme in paraffin‑embedded tissue (FFPE) to confirm myeloid lineage in acute leukemias and myeloproliferative neoplasms. This is the gold‑standard morphological method for the differential diagnosis of poorly differentiated hematopoietic malignancies.

يكشف فحص كيمياء الأنسجة المناعية للميلوبيروكسيديز (MPO) عن إنزيم الميلوبيروكسيديز في الأنسجة المطمورة بالبارافين، مما يؤكد النسب النقوي لسرطانات الدم الحادة والأورام التكاثرية النقوية. وهو المعيار الذهبي للتشخيص التفريقي للأورام الدموية الخبيثة سيئة التمايز.

Feature Our MPO IHC Test Flow Cytometry MPO
Methodology Immunohistochemistry on FFPE tissue Fluorescence‑based detection on fresh cell suspension
TAT (Routine) 5 working days 1–2 days (requires immediate sample processing)
Morphologic Correlation Direct visualisation of tumour tissue architecture Limited to single‑cell suspension; no tissue context
Sample Type FFPE block / formalin‑fixed tissue Fresh bone marrow or blood in special transport medium
Clinical Use Myeloid lineage determination in solid tissue biopsies Routine immunophenotyping of liquid haematological samples

Consultant’s Note & Patient Safety

Dr. Reddy

Dr. Prabhakar Reddy (DHA: 61713011, Surgical Pathologist)

“Facing a possible cancer diagnosis is deeply unsettling. MPO IHC offers histological certainty for myeloid origin, but no single stain replaces a full clinical picture. I always emphasise that a negative MPO does not exclude malignancy — it must be interpreted alongside morphology and ancillary molecular studies.”

Critical Medication Warning

Do not discontinue or modify any prescribed medication (including chemotherapy or anticoagulants) without explicit instruction from your supervising consultant. Biopsy guidance and MPO result interpretation must be integrated into your overall treatment plan.

Exclusion Criteria & Emergency Red Flags

  • Exclusion: Uncontrolled bleeding diathesis, anticoagulation that cannot be paused for biopsy, or insufficient tissue in the provided block (fewer than 5 tissue sections available).
  • Exclusion (Minors): In accordance with Federal Decree-Law No. 41 of 2024 and CDS Law 2026, patients under 18 require a custodial consent form and a paediatric oncologist’s referral.
  • Urgent signs: If you develop fever >38°C, uncontrolled bleeding at the biopsy site, or sudden severe pain, proceed immediately to the emergency department. Do not wait for test results if you feel acutely unwell.

Frequently Asked Questions – Patient Guidance

1. What does a positive MPO immunohistochemistry stain mean for my diagnosis?

Positive MPO staining confirms that your tumour cells originate from the myeloid line, which helps classify leukemias such as AML. This enzyme is specific to neutrophils and their precursors, so a positive result identifies acute myeloid leukaemia, myelodysplastic syndrome, or myeloproliferative neoplasms with granulocytic differentiation. Your oncologist will combine this with other markers (CD34, CD117) to finalise the subtype.

س: ماذا تعني نتيجة MPO الإيجابية لتشخيصي؟

ج: تؤكد صبغة MPO الإيجابية أن الخلايا السرطانية تنشأ من السلالة النقوية، مما يساعد في تصنيف سرطانات الدم مثل ابيضاض الدم النقوي الحاد (AML).

2. Can this MPO test be performed on any body site or only on bone marrow?

MPO IHC can be performed on formalin‑fixed paraffin‑embedded tissue from virtually any anatomical site, including lymph nodes, spleen, or extramedullary myeloid sarcoma. Unlike flow cytometry, which often requires fresh bone marrow aspirate, this works on archived biopsy blocks, enabling retrospective analysis and correlation with tissue architecture. Your doctor must provide the site and clinical history for accurate interpretation.

س: هل يمكن إجراء هذا الاختبار على أي موقع من الجسم أم على نخاع العظم فقط؟

ج: يمكن إجراء تحليل MPO بالكيمياء المناعية على الأنسجة المطمورة بالبارافين من أي موقع تشريحي تقريباً، بما في ذلك العقد اللمفاوية أو الطحال أو الساركوما النقوية خارج النخاع.

3. How accurate is immunohistochemistry for MPO compared with genetic tests?

IHC for MPO offers >95% concordance with genetic myeloid markers and directly visualises protein expression within tissue, making it essential for morphologic diagnosis. While next‑generation sequencing detects mutations (e.g., NPM1, FLT3), MPO IHC establishes lineage commitment that genetic data alone cannot guarantee. The two methods are complementary; a combined approach gives the most robust diagnosis under UAE MOHAP guidelines.

س: ما مدى دقة كيمياء الأنسجة المناعية لـ MPO مقارنة بالفحوصات الجينية؟

ج: توفر طريقة IHC لـ MPO توافقاً يزيد عن 95٪ مع الواسمات الجينية النقوية وتُظهر التعبير البروتيني مباشرة في الأنسجة، مما يجعلها أساسية للتشخيص الشكلي.

Regulatory

Federal Decree-Law No. 41 of 2024 Art. 87; CDS Law 2026 (minors); UAE PDPL. All patient data encrypted under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139).

Lab & Method

LOINC: 58420-9 (Myeloperoxidase [Presence] in Tissue by Immune stain). ICD‑10: C92.00, C92.40, D71.

Logistics

Sample: FFPE block or formalin‑fixed tissue. TAT: 5–7 days. Price: 450 AED inclusive. WhatsApp: +971 54 548 8731.

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