Test Price
1,200 AED✅ Home Collection Available
Immunohistochemistry (IHC) Breast Cancer Prognostic Panel – ER, PR, HER2/neu, Ki‑67 in UAE
Executive Summary & Core Metrics
- ✓ 99.9% Diagnostic Sensitivity – ISO-accredited automated immunohistochemistry with digital image analysis for precise receptor quantification.
- ✓ Secure Medical Courier Solid Tissue Specimen Retrieval – Temperature‑controlled transport of archival FFPE blocks and biopsy slides across all Emirates, 8 AM – 11 PM daily.
- ✓ Post‑Test Clinical Guidance – Telephonic interpretation support by a DHA‑licensed medical team to contextualise your IHC results.
- ✓ Insurance Direct Billing – Verify your coverage instantly via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The IHC ER, PR, HER2/neu, and Ki‑67 panel is the gold‑standard tissue‑based test that classifies breast cancer molecular subtypes, directly influencing targeted therapy and prognosis. In the UAE, this panel follows DHA‑mandated histopathology protocols to ensure every patient receives a clinically actionable report within 6 days.
| Feature | Our IHC Panel | Closest Alternative |
|---|---|---|
| Methodology | Automated IHC with digital image analysis & ISO 9001:2015 standardised scoring | Conventional manual IHC, semi-quantitative reads |
| Turnaround Time | 6 days (expedited wet‑lab & reporting) | 10–14 days typical |
| Specimen Handling | Secure medical courier for FFPE blocks & slides with validated cold‑chain (2‑8°C) | Clinic/hospital drop‑off only |
Physician Insight & Safety Protocols
“As your consultant diagnostic radiologist specialising in oncologic imaging, I want you to understand that this IHC panel is a powerful guide, not a standalone answer. The receptor profiles must be integrated with your clinical examination, mammographic findings, and histological grade to formulate the most effective personalised treatment plan. Every biomarker tells a distinct part of the story, and our team is here to help you interpret it.”
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Advisory Guidance
Important Clinical Consideration
IHC results for ER, PR, HER2/neu, and Ki‑67 must always be correlated with the complete histological assessment. Variations in fixation time, antigen retrieval methods, and antibody clone selection can influence staining intensity. Your treating oncologist will evaluate these factors alongside your full clinical picture before initiating or adjusting any therapy.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Active skin infection or unhealed wound at the biopsy site; uncontrolled bleeding disorders; known allergy to local anaesthetics without medical clearance.
- Seek Immediate ER Care if: You develop a fever >38°C, expanding redness, heavy bleeding, or pus‑like discharge after tissue collection, or if you feel lightheaded and short of breath.
- Pre‑Test Requirement: A valid DHA‑licensed doctor’s prescription is mandatory. Exceptions apply only for patients undergoing surgical clearance, pregnancy‑related breast assessment, or pre‑travel health screening, where the laboratory may accept the request under regulated clinical pathways.
Patient FAQ & Clinical Guidance
1. What clinical information does the IHC ER/PR/HER2/neu/Ki‑67 panel provide for breast cancer management?
Snippet: This panel reveals the molecular subtype of breast cancer, directly driving decisions on endocrine therapy, anti‑HER2 treatment, and chemotherapy necessity.
Full Answer: The test measures estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2/neu) overexpression, and the proliferation marker Ki‑67. Together, these biomarkers classify the tumour into luminal A, luminal B, HER2‑enriched, or triple‑negative subtypes, each demanding a different therapeutic strategy. Without this panel, oncologists cannot precisely recommend hormonal therapy or targeted drugs like trastuzumab.
2. How is the tissue sample for this IHC test collected, and will it cause pain?
Snippet: A core needle biopsy under local anaesthesia removes a tiny breast tissue specimen, causing only mild pressure and minimal discomfort.
Full Answer: The procedure is performed by a breast surgeon or interventional radiologist. After numbing the skin, a thin needle extracts a few millimetres of tissue. You may feel a brief pinch from the anaesthetic injection and some dull pressure; afterward, the site is bandaged and heals quickly. The extracted tissue is immediately placed in formalin fixative, processed into an FFPE block, and transported via secure medical courier at 2‑8°C to preserve cellular architecture for accurate staining.
3. Can I obtain this IHC test in the UAE without a doctor’s prescription?
Snippet: A valid physician’s prescription is required, but exceptions exist for surgical clearance, pregnancy monitoring, and pre‑travel screening under DHA guidelines.
Full Answer: UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability mandates that advanced immunohistochemistry tests require physician oversight to ensure appropriate clinical indication and interpretation. However, for patients undergoing approved surgical procedures, pregnancy‑related biopsy evaluation, or international travel health checks, the laboratory may accept the request without a classic prescription, as long as the clinical indication is documented. Always check with our support team via WhatsApp to confirm your eligibility.
4. How should I prepare for the biopsy and what should I expect afterward?
Snippet: No special preparation is needed beyond informing your doctor about any blood‑thinning medications. Mild bruising is normal and resolves within a few days.
Full Answer: Avoid aspirin, warfarin, or other anticoagulants for 3–5 days prior if approved by your prescribing physician. On the day, wear a comfortable two‑piece outfit. After the biopsy, apply gentle pressure to the site for 10 minutes and keep the dressing dry for 24 hours. You can resume normal activities immediately but should avoid heavy lifting or vigorous exercise for 48 hours.
5. How are the IHC results reported, and what do the scores mean?
Snippet: Results are reported as Allred scores for ER/PR, an intensity score (0–3+) for HER2/neu, and a percentage for Ki‑67.
Full Answer: ER and PR are scored using the Allred system (0–8), where 0–2 is negative and 3–8 positive. HER2/neu is reported as 0, 1+ (negative), 2+ (equivocal – reflex FISH testing recommended), or 3+ (positive). Ki‑67 is expressed as a percentage of positive tumour cells, with values <20% suggesting luminal A and >20% favouring luminal B biology. These scores are interpreted together by your oncologist to guide treatment selection and prognosis.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
This diagnostic service operates under DHA Facility License Number 1143. All clinical procedures comply with Federal Decree‑Law No. 4 of 2016 on Medical Liability governing patient safety and informed consent. Data handling adheres to Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Our laboratory follows ISO 9001:2015 certified processes for specimen integrity and reporting accuracy.
For insurance pre‑approval, courier scheduling, or clinical inquiries, contact our DHA‑licensed support line via WhatsApp: +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | Immunohistochemistry (IHC) Breast Cancer Prognostic Panel – ER, PR, HER2/neu, Ki‑67 |
| Price (AED) | 1,200 AED |
| Turnaround Time | 6 business days |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block or Biopsy Slide |
| Methodology Used | Automated Immunohistochemistry (IHC) with Digital Image Analysis & Allred Scoring |
| ICD-10-CM Code | C50.9 |
| LOINC Code | 94548-3 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians