Test Price
450 AED✅ Home Collection Available
H3K27M & H3K27me3 Immunohistochemistry Test in UAE | 450 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval (Home collection not available; sample must be submitted via tissue courier).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The H3K27M immunohistochemistry test detects the mutant histone protein in tumor tissue, providing rapid diagnostic confirmation of diffuse midline gliomas and other H3K27-altered cancers. This test is used by oncologists and surgical pathologists across the UAE to guide targeted therapy and genetic counselling.
| Feature | Our Test (IHC) | Closest Alternative (NGS Panel) |
|---|---|---|
| Precision & Target | Mutation-specific antibody (H3K27M) | DNA sequencing covering multiple genes |
| Methodology | Immunohistochemistry (FFPE) | Next‑Generation Sequencing (NGS) |
| Turnaround Time | 5–7 working days | 10–14 working days |
| Clinical Utility | Direct detection of actionable mutation in midline gliomas | Comprehensive profiling, often requiring bioinformatics support |
Physician Insight & Safety Protocols
"As a DHA-licensed specialist diagnostic radiologist, I emphasize that the H3K27M immunohistochemistry result must always be correlated with radiological findings and full clinical history to confirm a diagnosis of diffuse midline glioma. A positive stain helps identify patients eligible for targeted trials, but a negative result does not exclude other high-grade gliomas. Maintaining open communication with your multidisciplinary team is essential for optimal care."
— Mr. Prabhakar Reddy Kalathoor (Specialist Diagnostic Radiology, DHA License: 61713011)
Advisory Notes
Do not discontinue prescribed medication without consulting your doctor. This test does not replace clinical judgement or ongoing treatment decisions.
Exclusion and Safety Criteria
- This test is intended for diagnostic confirmation in patients with a suspicious midline brain or spinal lesion, not for screening.
- Exclusion: Patients unable to undergo a safe tumor biopsy procedure (coagulopathy, inaccessible lesion) are not candidates.
- ER Red Flags: If you experience acute neurological decline, vision loss, seizures, or signs of raised intracranial pressure (severe headache, vomiting, altered consciousness), seek emergency medical attention immediately—do not wait for this scheduled test.
Patient FAQ & Clinical Guidance
1. What is the H3K27M immunohistochemistry test used for?
This detects the H3K27M mutation protein in tumor tissue to diagnose diffuse midline gliomas accurately. It is the standard first‑line assay for identifying H3K27‑altered gliomas in the brainstem, thalamus, or spinal cord. A positive result supports the diagnosis and can guide enrolment in clinical trials.
2. How should I prepare and what sample is required?
You need a formalin‑fixed paraffin‑embedded (FFPE) tumor block or biopsy slides. No fasting or medication changes are required. Bring the histopathology report and clinical history. The sample must be submitted via secure medical courier; home phlebotomy is not applicable for this solid tissue specimen.
3. When will I receive the results and how are they interpreted?
Results are available within 5–7 days and must be interpreted by your oncologist with imaging. A positive stain indicates the presence of the H3K27M mutation, confirming a high‑grade midline glioma. A negative result may still warrant additional molecular testing. Our team provides a telephonic consultation to help you understand the report.
UAE Regulatory & Data Privacy Adherence
Compliance with UAE Laws: DNA Labs UAE is fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is handled with strict confidentiality and in accordance with DHA regulations.
Clinical & Logistical Metadata
| Test Name | H3K27M & H3K27me3 Immunohistochemistry (IHC) Test |
| Price (AED) | 450 AED |
| Turnaround Time | 5–7 Working Days |
| Sample Type / Matrix | Archival Tissue Specimen (FFPE Tumor Block or Biopsy Slides) – Secure Medical Courier Solid Tissue Specimen Retrieval |
| Methodology Used | Immunohistochemistry (IHC) on Formalin-Fixed Paraffin-Embedded (FFPE) Tissue |
| ICD-10-CM Code | C71.9 |
| LOINC Code | 79720-0 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Provided by DNA Labs UAE |
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