Test Price
450 AED✅ Home Collection Available
CD56 Immunohistochemistry (IHC) Test | 450 AED | DHA Licensed Laboratory Dubai
Executive Summary & Core Metrics
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO-accredited processing with validated CD56 monoclonal antibody.
- Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval – archival FFPE blocks and biopsy slides collected from accredited facilities.
- Clinical Guidance: Telephonic post-test clinical guidance for result interpretation with your referring specialist.
- Insurance & Billing: Direct billing verification available via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The CD56 Immunohistochemistry (IHC) Test is a specialized pathology assay that detects the CD56 (NCAM) protein on tumor cell surfaces. This marker is essential for identifying neuroendocrine differentiation in neoplasms, aiding in the accurate diagnosis of small cell lung carcinoma, Merkel cell carcinoma, neuroendocrine tumors, and other aggressive malignancies where precise lineage characterization guides targeted therapy.
Our laboratory employs the automated DAKO EnVision FLEX+ detection system with validated primary antibodies against CD56, ensuring high sensitivity and specificity. The test is performed on formalin-fixed, paraffin-embedded (FFPE) tissue sections or archival biopsy slides, following strict internal quality control protocols aligned with ISO 15189 standards.
| Feature | Our CD56 IHC Test | Standard IHC Without CD56 Marker |
|---|---|---|
| Diagnostic Precision | >99% specificity using validated CD56 antibody with automated interpretation | May miss neuroendocrine differentiation, leading to incomplete tumor classification |
| Methodology | Advanced IHC with automated DAKO EnVision FLEX+ system and digital pathology review | Manual or less sensitive polymer detection systems with higher inter-observer variability |
| Turnaround Time | 5–7 business days from tissue receipt; same-day report dispatch by 6:00 PM | 7–10 business days; results often delayed due to manual batch processing |
Physician Insight & Safety Protocols
“CD56 IHC is a powerful diagnostic tool for identifying neuroendocrine differentiation, but no single marker should be interpreted in isolation. A positive result must be correlated with the complete histomorphology, clinical presentation, and ancillary studies. I strongly encourage patients to review these results with their treating oncologist before making any therapeutic decisions.”
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Safety Advisory
⚠️ Important Clinical Precaution
CD56 IHC is performed exclusively on archival tissue specimens. No fresh tissue or blood collection is required for this assay. Patients are advised to provide complete clinical history, radiographic findings, and prior pathology reports to ensure accurate interpretation. False-positive or false-negative results may occur if the tissue sample is insufficient, poorly preserved, or if the antibody clone used is not validated for the specific tumor type. All results should be correlated with the full clinical picture by a qualified specialist.
Patient Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Insufficient or degraded FFPE tissue block or biopsy material
- Unavailability of corresponding Hematoxylin and Eosin (H&E) stained section for morphological correlation
- Informed consent not obtainable from the patient or legal representative
Emergency Red Flags
If you experience new-onset severe pain, high fever (>38.5 °C), uncontrolled bleeding from a recent biopsy site, or signs of local infection (redness, swelling, purulent discharge) after tissue collection, visit the nearest emergency department immediately.
Patient FAQ & Clinical Guidance
1. What is a CD56 immunohistochemistry test and why is it performed?
The CD56 IHC test detects the neural cell adhesion molecule (NCAM) on tumor cells. It is primarily used to confirm neuroendocrine differentiation in cancers such as small cell lung carcinoma, Merkel cell carcinoma, and other neuroendocrine neoplasms. This information helps your oncology team classify the tumor accurately and select the most appropriate targeted or chemotherapy regimen.
2. How should I prepare for the CD56 IHC test?
No special preparation such as fasting or medication adjustment is required. You need to provide the histopathology report, the original FFPE tissue block or unstained biopsy slides, and relevant clinical history including prior imaging and biopsy site details. Our courier service will coordinate the secure transfer of the archival tissue to our laboratory.
3. What does a positive CD56 result indicate?
A positive CD56 result indicates the presence of neuroendocrine differentiation within the tumor cells. This finding is characteristic of small cell lung carcinoma, Merkel cell carcinoma, and various neuroendocrine tumors. However, positivity must be interpreted alongside morphological features, other IHC markers (e.g., chromogranin, synaptophysin, CK20), and clinical context to avoid misdiagnosis. Always discuss the integrated report with your oncologist.
4. How long does it take to get CD56 IHC results?
The turnaround time is typically 5 to 7 business days from the moment the archival tissue specimen is received in our laboratory. This allows for proper sectioning, automated staining, quality control, and pathologist review. Expedited processing may be available on a case-by-case basis upon request.
UAE Regulatory & Data Privacy Adherence
Your Data Security & Legal Compliance
DNA Labs UAE operates under DHA Facility License Number 1143 and adheres to the highest standards of patient data protection. All personal health information is handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent procedures follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Your results are encrypted, securely stored, and shared only with authorized healthcare providers involved in your care.
Clinical & Logistical Metadata
| Test Name | CD56 Immunohistochemistry (IHC) Test |
| Price (AED) | 450 AED |
| Turnaround Time | 5–7 Business Days (Archival Tissue Processing) |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block / Biopsy Slides |
| Methodology Used | Automated Immunohistochemistry (IHC) – DAKO EnVision FLEX+ Detection System |
| ICD-10-CM Code | C7A.8 |
| LOINC Code | 10462-9 |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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