Test Price
450 AED✅ Home Collection Available
CD103 Immunohistochemistry (IHC) Test in UAE | 450 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited IHC processing with CD103 monoclonal antibody specificity.
Premium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval via temperature-controlled cold-chain logistics from hospital or clinic to our CAP-accredited laboratory.
Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed consultants.
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Test Overview & Methodology
The CD103 Immunohistochemistry (IHC) test detects CD103 integrin αEβ7 expression on tumour cells in formalin-fixed paraffin-embedded (FFPE) tissue. This assay is critical for classifying haematological malignancies such as hairy cell leukaemia and specific subtypes of T-cell lymphoma, providing essential diagnostic clarity for oncologists and haematopathologists.
| Feature | Our CD103 IHC Test | Closest Alternative (Standard IHC Panel) |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity, CD103-specific monoclonal antibody with DAB chromogen detection | ~90% sensitivity, relies on pan‑lymphoid markers without CD103 confirmation |
| Methodology | Advanced IHC on FFPE blocks with automated Ventana or Leica platforms, ISO 9001:2015 accredited | Manual or semi‑automated IHC, laboratory‑specific protocols |
| Turnaround Time | 5 working days (standard biopsy) / 7 working days (large complex resections) | 7–10 working days |
| Sample Requirement | Tumour tissue in 10% neutral buffered formalin or FFPE block; histopathology report, biopsy site and clinical history mandatory | FFPE block only; limited clinical correlation |
Physician Insight & Safety Protocols
“As a specialist in diagnostic radiology, I emphasise that a CD103-positive IHC result must be correlated with full histomorphology, flow cytometry, and clinical presentation before establishing a definitive diagnosis. Treatment decisions should never rest on a single stain alone; multidisciplinary evaluation remains the gold standard for patient safety.” – Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Important Medication Advisory
Do not discontinue any prescribed medication or alter your therapeutic regimen based solely on CD103 IHC results. These findings serve as a diagnostic adjunct and must be interpreted by your treating physician within the full clinical context.
Exclusion Criteria & Clinical Red Flags
- Exclusion: Insufficient tumour cellularity (fewer than 100 viable tumour cells) or necrotic tissue in the submitted block; decalcified samples such as bone marrow trephine may yield false-negative staining.
- Exclusion: Specimen not fixed in 10% neutral buffered formalin; prolonged fixation exceeding 72 hours leads to antigen masking and unreliable results.
- Red Flag: Sudden onset of severe fatigue, high fever above 38.5°C, or unexplained bleeding or bruising while awaiting results — seek emergency care immediately.
- Red Flag: Rapidly enlarging lymph nodes or organomegaly accompanied by B-symptoms such as night sweats or unexplained weight loss — report to your oncologist urgently.
Patient FAQ & Clinical Guidance
1. What does a positive CD103 IHC result indicate for my lymphoma diagnosis?
A positive CD103 immunostaining typically supports a diagnosis of hairy cell leukaemia or a subset of splenic marginal zone lymphomas. The final diagnosis requires integration of full histomorphology, flow cytometry, and clinical history — this sensitive and specific marker helps differentiate from other low-grade B-cell neoplasms.
2. Why is the histopathology report and biopsy site mandatory before testing?
The histopathology report provides essential morphological context and prior IHC results, enabling our pathologists to select optimal antibody clones and interpret staining patterns accurately, thereby avoiding diagnostic errors and ensuring the result is clinically actionable.
3. How is my tissue sample collected and when will I receive results?
Home phlebotomy is not applicable for tissue-based CD103 IHC. A biopsy must be performed in a hospital or clinic; the formalin-fixed tissue or paraffin block is retrieved by our secure medical courier logistics team. Once received at the laboratory, your report is available within 5 working days for standard biopsies and 7 working days for large complex specimens, with same-day electronic delivery.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
- Facility licensed by Dubai Health Authority: DHA Facility License No. 1143
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139)
- All procedures adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Clinical safety and patient consent governed by Federal Decree-Law No. 4 of 2016 on Medical Liability
- Sample collection performed by DHA-licensed professionals under strict cold-chain protocols
Clinical & Logistical Metadata
| Test Name | CD103 Immunohistochemistry (IHC) Test |
| Price (AED) | 450 AED |
| Turnaround Time | 5–7 Working Days |
| Sample Type / Matrix | Archival Tissue Specimen (FFPE Block or Biopsy Slides) |
| Methodology Used | Automated Immunohistochemistry (IHC) with CD103 Monoclonal Antibody |
| ICD-10-CM Code | C91.4 (Hairy cell leukaemia) |
| LOINC Code | 104535-2 (CD103 [Presence] in Tissue by Immunohistochemistry) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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