Test Price
450 AEDโ Home Collection Available
Caldesmon Immunohistochemistry (IHC) Test in UAE | 450 AED | DHA Guidelines
Executive Summary & Core Metrics
Test Overview & Methodology
The Caldesmon Immunohistochemistry (IHC) Test is a definitive diagnostic tool for distinguishing smooth muscle tumors from other spindle cell neoplasms, particularly in uterine and soft tissue pathology. Our advanced IHC methodology employs the Leica BOND-MAX automated staining platform with a monoclonal anti-h-caldesmon antibody, offering high sensitivity and specificity. The test is performed on formalin-fixed paraffin-embedded (FFPE) tissue blocks, ensuring reliable results with a turnaround time of 5โ7 working days depending on block complexity. Expert pathologists correlate findings with haematoxylin and eosin (H&E) morphology and clinical history for accurate diagnosis.
| Parameter | Our Test (Caldesmon IHC) | Closest Alternative |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity with automated staining & digital quantification | 85โ92% sensitivity; manual interpretation, higher inter-observer variability |
| Methodology | IHC on Leica BOND-MAX, anti-h-caldesmon monoclonal antibody, DHA protocol | Conventional IHC with older antibody clones, longer manual protocols |
| Speed | Block: 5 days; complex tissue: 7 days (sample daily by 6 pm) | 7โ10 working days |
| Pre-test Requirement | Submit formalin-fixed paraffin-embedded block with histopathology report, biopsy site & clinical history | Often demands full tissue section, fragmented reporting |
Physician Insight & Safety Protocols
โCaldesmon expression must always be correlated with morphological findings and clinical history. A positive result strongly supports smooth muscle differentiation but is not a standalone diagnostic marker. I interpret IHC results in conjunction with haematoxylin and eosin sections and relevant clinical data to avoid misdiagnosis. Patient safety is paramount โ tissue sampling should be performed by qualified personnel under sterile conditions.โ
โ Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA License: 61713011
โ ๏ธ Do not discontinue prescribed medication without consulting your doctor.
Exclusion Criteria & Safety Red Flags
- Exclusion: Pregnant or lactating individuals without explicit obstetrician approval for biopsy.
- Exclusion: Patients with active bleeding disorders or anticoagulation therapy that cannot be safely paused prior to tissue sampling.
- ER Red Flag: Sudden onset of heavy bleeding at biopsy site โ seek immediate medical attention.
- ER Red Flag: Fever >38.5ยฐC or signs of infection (redness, pus, warmth) post-procedure โ go to emergency.
Patient FAQ & Clinical Guidance
1. What does the Caldesmon IHC test detect?
Caldesmon IHC detects h-caldesmon protein to distinguish smooth muscle tumors from other spindle lesions. This test is crucial for differentiating leiomyosarcoma from gastrointestinal stromal tumors, schwannomas, and other spindle cell neoplasms. Positive staining confirms smooth muscle origin, guiding oncological management and surgical planning.
2. How should I prepare for a Caldesmon IHC test?
No fasting or medication changes are needed; only formalin-fixed tumor tissue is required for Caldesmon testing. The test is performed on a tissue sample already obtained via biopsy or surgery. You must provide a copy of the histopathology report, biopsy site, and clinical history. The specimen is submitted as a formalin-fixed paraffin-embedded block at room temperature. Do not stop any medications prior to the biopsy unless instructed by your surgeon.
3. What do the results of Caldesmon IHC mean?
Positive h-caldesmon expression indicates smooth muscle origin, supporting leiomyosarcoma, while negative results suggest alternative spindle tumors. A positive result with appropriate morphology confirms smooth muscle differentiation and is often used to diagnose uterine or soft tissue leiomyosarcoma. Negative staining shifts suspicion toward endometrial stromal sarcoma or solitary fibrous tumor. Clinical correlation with radiology and patient history is essential for final diagnosis.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Legal Compliance: DNA Labs UAE operates under DHA Facility License No. 1143 (Premises 105, Floor 1, Building 33, Dubai Healthcare City). We adhere strictly to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All test results and patient data are encrypted, stored securely, and accessed only by authorized medical personnel. Your privacy is our priority.
Clinical & Logistical Metadata
| Test Name | Caldesmon Immunohistochemistry (IHC) Test |
| Price (AED) | 450 |
| Turnaround Time | 5โ7 working days |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block |
| Methodology Used | Immunohistochemistry (IHC) on Leica BOND-MAX, anti-h-caldesmon monoclonal antibody |
| ICD-10-CM Code | C49.9 (Malignant neoplasm of connective and soft tissue, unspecified) |
| LOINC Code | 48001-7 (Caldesmon Ab [Presence] in Tissue by Immune stain) |
| DHA Facility License & Laboratory Address | License No. 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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