RAG2 Gene Combined Immunodeficiency NGS Test in Dubai – 2800 AED

Executive Summary & Core Metrics

Diagnostic Accuracy: 99.9% sensitivity via ISO 9001:2015 certified next-generation sequencing workflow.
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection: ISO-certified home blood draw available daily from 8 AM to 11 PM across Dubai and Abu Dhabi.
Post-Test Clinical Guidance: Telephonic consultation with a consultant medical geneticist to interpret results and support clinical decision-making.
Insurance Verification: Direct coverage check via WhatsApp +971 54 548 8731.

Test Overview & Methodology

This advanced genetic test employs next-generation sequencing to analyze the RAG2 gene for pathogenic variants that cause combined immunodeficiency, characterised by absent B and T cells with normal or elevated NK cells. It provides a definitive molecular diagnosis for conditions such as severe combined immunodeficiency (SCID) and Omenn syndrome, enabling personalised treatment planning, genetic counselling, and family cascade screening.

Feature	Our NGS Test	Alternative Sanger / Single Variant Test
Sequencing Depth	High-throughput, 1000x coverage	Low, targeted regions only
Variant Detection	Full gene sequencing including novel mutations	Only known hotspots
Turnaround Time	3–4 Weeks	2–4 Weeks

Physician Insight & Safety Protocols

Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403

"Receiving a genetic diagnosis for your child's immune deficiency can be an emotional experience. Our team provides compassionate guidance and precise molecular results, ensuring you have the clarity needed for informed treatment decisions. Always interpret these findings alongside immunological and clinical evaluations."

Advisory – Medication Continuity

⚠️ Important: Do not discontinue or alter any prescribed medication without prior consultation with your treating physician. Genetic test results are intended to guide clinical management, not to replace current therapy without specialist oversight.

Exclusion Criteria & Safety Red Flags

Avoid blood collection during acute infection or febrile illness, as these may confound immunological parameters.
For minors (under 18 years), mandatory parental or guardian consent is required as per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
If you experience fainting, severe bleeding, or an allergic reaction following phlebotomy, seek emergency medical attention immediately.
All testing is performed under ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139).

Patient FAQ & Clinical Guidance

1. What is the RAG2 gene and how is it linked to combined immunodeficiency?

The RAG2 gene encodes a protein essential for V(D)J recombination, a process critical for lymphocyte development. Mutations cause a complete absence of B and T cells while NK cells remain present, leading to severe combined immunodeficiency often presenting as Omenn syndrome. This test identifies pathogenic variants for a precise molecular diagnosis.

2. How long does it take to get RAG2 gene test results and what do they mean?

Results are typically available within 3 to 4 weeks and include a detailed report of identified pathogenic variants. A positive result confirms the molecular diagnosis of RAG2-related SCID, guiding decisions for hematopoietic stem cell transplantation or gene therapy. Negative results may indicate the need for broader immunodeficiency panel testing.

3. Is home collection available for this test in the UAE and how can I schedule it?

Yes, we offer ISO-certified cold-chain home collection with VIP mobile phlebotomy across the UAE. Contact our support team via WhatsApp at +971 54 548 8731 to schedule a convenient appointment, including same-day service in Dubai and Abu Dhabi. Collection is available daily from 8 AM to 11 PM.

4. Will my insurance cover the cost of this genetic test?

Coverage varies by insurance provider and policy. Our team can verify your insurance benefits directly via WhatsApp at +971 54 548 8731. Please have your membership details ready for a quick eligibility check.

5. What should I do with the test results after I receive them?

Schedule a follow-up consultation with your immunologist or genetic specialist. Our consultant medical geneticist is available for a telephonic discussion to help interpret the report and outline next steps for clinical management and family screening.

UAE Regulatory & Data Privacy Adherence

Your genetic data and personal health information are protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All testing procedures and patient consent protocols comply with Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE adheres to strict data security standards to ensure your privacy and confidentiality are maintained throughout the testing process.

Clinical & Logistical Metadata

Test Name	RAG2 Gene Combined Immunodeficiency NGS Test
Price (AED)	2,800 AED
Turnaround Time	3–4 Weeks
Sample Type / Matrix	Peripheral Whole Blood (EDTA)
Methodology Used	Next-Generation Sequencing (NGS)
ICD-10-CM Code	D81.31 (Severe combined immunodeficiency due to RAG2 deficiency)
LOINC Code	101370-9
DHA Facility License & Laboratory Address	DHA Facility License No. 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE