Test Price
1,500 AED✅ Home Collection Available
Immunoglobulin G Subclass 4 (IgG4) Test in UAE | 1,500 AED | DHA Licensed Laboratory
Executive Summary & Core Metrics
High-precision serum IgG4 subclass quantification for the diagnosis and monitoring of IgG4-related disease (IgG4‑RD) and selective immunodeficiency.
- Accuracy: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited immunonephelometry.
- Turnaround: Same-day results for samples collected Monday–Thursday before 4:00 PM.
- Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM).
- Post-test Support: Complimentary telephonic consultation with a DHA‑licensed physician for result interpretation.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The Immunoglobulin G Subclass 4 (IgG4) test precisely quantifies circulating IgG4 antibody levels using high‑resolution immunonephelometry on a Siemens BN II platform. This assay is the gold‑standard method for diagnosing IgG4‑Related Disease (IgG4‑RD), a fibroinflammatory condition that can affect virtually any organ system, and for evaluating patients with recurrent infections suggestive of selective IgG subclass deficiency. Each sample undergoes rigorous internal quality control with intra‑assay coefficients of variation below 2%, ensuring results you can trust for clinical decision‑making.
| Feature | DNA Labs UAE IgG4 Test | Standard ELISA / RID Alternative |
|---|---|---|
| Methodology | High‑resolution immunonephelometry (Siemens BN II) | Enzyme‑linked immunosorbent assay or radial immunodiffusion |
| Precision & Sensitivity | 99.9% sensitivity; CV <2% intra‑assay | Moderate sensitivity; manual interpretation prone to inter‑laboratory variation |
| Turnaround Time | Same day (Mon–Thu collection before 4 PM) | 3–7 working days |
| Regulatory Accreditation | ISO 9001:2015 & DHA Facility License No. 1143 | Often lacks UAE‑specific quality certification |
| Clinical Integration | Free telephonic consultation with DHA‑licensed physician | No integrated specialist review |
Physician Insight & Safety Protocols
“The IgG4 subclass assay is a powerful tool for unmasking occult inflammatory conditions that can mimic malignancy or infection. I remind patients that isolated IgG4 values must always be interpreted alongside clinical presentation, imaging findings, and histopathology when indicated. Never initiate or discontinue immunomodulatory therapy based solely on a single laboratory result — always partner with your treating physician for a comprehensive assessment.”
Advisory – Medication & Pretreatment Considerations
Important Pretreatment Guidance
- Do not discontinue prescribed corticosteroid, biologic, or immunomodulatory therapy without consulting your doctor — abrupt withdrawal may cause disease flare.
- Inform your referring physician if you have received intravenous immunoglobulin (IVIG) within the past 6 weeks, as this can produce falsely elevated IgG4 levels.
- Postpone collection if you have received a live attenuated vaccine (e.g., MMR, varicella, yellow fever) within the preceding 4 weeks.
- Disclose all over‑the‑counter supplements, including biotin >5 mg/day, which may interfere with immunoassay results.
Exclusion Criteria & Emergency Red Flags
Do Not Proceed With Collection If Any of the Following Apply
- Acute febrile illness with core temperature >38.5°C — reschedule once afebrile for at least 48 hours.
- Active systemic infection (sepsis, abscess, pneumonia) requiring urgent medical attention.
- Recent IVIG therapy within 6 weeks — results will not reflect baseline IgG4 status.
- ER Alert: Seek immediate emergency care if you experience sudden chest pain, difficulty breathing, severe abdominal pain, or signs of anaphylaxis (swollen tongue, throat tightness, stridor) after venipuncture.
- Contact the laboratory at +971 54 548 8731 if you notice excessive bleeding, enlarging hematoma, or signs of infection (redness, warmth, purulent discharge) at the puncture site.
Patient FAQ & Clinical Guidance
1. What is the Immunoglobulin G Subclass 4 (IgG4) test, and why is it prescribed?
The IgG4 test measures the concentration of IgG4 antibodies in your blood. Physicians prescribe this assay to help diagnose IgG4-Related Disease (IgG4‑RD) — a chronic fibroinflammatory condition that can cause painless swelling of organs such as the pancreas (autoimmune pancreatitis), salivary glands, lymph nodes, retroperitoneum, and bile ducts. It is also used to identify selective IgG subclass deficiencies in patients with recurrent sinopulmonary infections and to monitor disease activity during immunomodulatory therapy.
2. How should I prepare for the IgG4 subclass blood draw?
Overnight fasting of 10–12 hours is recommended to obtain a clear serum sample; only plain water is permitted. Avoid taking any immunoglobulin supplements, high‑dose biotin (>5 mg/day), or heavy fatty meals after 10 PM the night before. Wear clothing with loose sleeves that allow easy access to the antecubital vein. Our certified phlebotomist will collect approximately 2 mL of venous blood in an SST serum separator tube, which is immediately processed under ISO‑specified cold‑chain conditions for same‑day analysis.
3. What do abnormal IgG4 results mean for my health?
Elevated IgG4 levels (>135 mg/dL in most reference ranges) may indicate active IgG4‑RD, chronic infection, or atopic/allergic conditions — repeat testing and full clinical correlation are essential. Low IgG4 concentrations (<8 mg/dL) can point to common variable immunodeficiency (CVID) or a selective IgG subclass deficiency, which may warrant immunological prophylaxis and specialist immunology referral. Always review your results with a DHA‑licensed physician who can integrate the laboratory data with your symptoms, imaging, and biopsy findings before making any treatment decisions.
UAE Regulatory & Data Privacy Adherence
Your Data, Your Rights — Fully Protected Under UAE Law
- Personal Data Protection: All patient information is processed in strict compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring lawful collection, storage, and sharing of your health data.
- Health Information Governance: Our laboratory infrastructure adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, guaranteeing secure electronic health records and confidential digital communication.
- Clinical Safety & Consent: Every blood collection procedure follows the standards set by Federal Decree‑Law No. 4 of 2016 on Medical Liability, safeguarding your rights to informed consent, safe clinical practice, and transparent complaint mechanisms.
- Accreditation: DNA Labs UAE operates under DHA Facility License No. 1143 and maintains ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) for quality management systems.
Clinical & Logistical Metadata
| Test Name | Immunoglobulin G Subclass 4 (IgG4) Test |
| Price (AED) | 1,500 AED |
| Turnaround Time | Same day (samples collected Mon–Thu before 4:00 PM) |
| Sample Type / Matrix | Serum (Venous Blood) |
| Methodology Used | High‑Resolution Immunonephelometry (Siemens BN II) |
| ICD-10-CM Code | D89.89 |
| LOINC Code | 2465-6 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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