Test Price
2,800 AED✅ Home Collection Available
GDNF Gene Hirschsprung Disease Type 3 Susceptibility Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
Clinical Guidance: Telephonic post-test result interpretation by DHA-licensed genetic specialists.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
This next-generation sequencing (NGS) test analyzes the complete coding region of the GDNF gene to detect pathogenic variants associated with increased susceptibility to Hirschsprung disease type 3. The test delivers 99.9% diagnostic sensitivity and supports early clinical monitoring, prophylactic planning, and informed family genetic counseling.
Test Overview & Methodology
This NGS-based genetic test sequences the entire coding region of the GDNF gene to identify pathogenic variants that confer elevated risk for Hirschsprung disease type 3 — a congenital condition characterized by the absence of nerve ganglia in the distal colon. Early molecular diagnosis enables timely surgical referral, surveillance planning, and carrier testing for at-risk family members.
| Feature | Our Test (UAE Premium) | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity | ~90% for Sanger sequencing (exon-limited) |
| Method | NGS – Full gene coverage including all coding exons and splice sites | Sanger sequencing (selected exons only) |
| Speed | 3–4 Weeks | 4–6 Weeks |
| Specimen | Blood, Extracted DNA, or FTA Card | Blood only |
Physician Insight & Safety Protocols
“As a consultant in medical genetics, I recognize the profound implications of testing for Hirschsprung disease susceptibility. This NGS-based assay provides highly accurate variant detection in the GDNF gene. However, a positive result indicates elevated risk — not a definitive diagnosis — and must be interpreted alongside clinical findings and family history. I strongly recommend post-test genetic counseling before any clinical decisions are made.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
⚠️ Medication Advisory
Do not discontinue or modify any prescribed medication or therapy without explicit direction from your treating physician. This genetic test provides a risk assessment only and does not replace ongoing clinical management or specialist consultations.
🔴 Safety Exclusion Criteria & Red Flags
Exclusion Criteria
- Infants with acute enterocolitis requiring urgent surgical intervention.
- Individuals already diagnosed with Hirschsprung disease undergoing active treatment without prior genetic counseling.
- Inability to obtain informed consent from a legal guardian.
ER Red Flags – Seek Immediate Care
- Severe abdominal distension accompanied by bilious vomiting.
- Failure to pass meconium or stool within the first 48 hours of life.
- Fever >38°C with abdominal tenderness or guarding.
Patient FAQ & Clinical Guidance
1. What does the GDNF gene susceptibility test detect?
This test identifies pathogenic variants in the GDNF gene that increase the risk of developing Hirschsprung disease type 3. It enables early clinical surveillance, surgical planning, and informed family genetic counseling.
2. How is the sample collected for this genetic test?
A peripheral blood sample, extracted DNA, or buccal swab on an FTA card is collected. Our VIP Mobile Phlebotomy service performs home collection under temperature-controlled cold-chain conditions from 8 AM to 11 PM daily.
3. When should I consider this test for my child?
Consider testing if there is a family history of Hirschsprung disease, unexplained neonatal constipation, abdominal distension, or failure to pass meconium within 48 hours of birth.
4. What does a positive result mean for my family?
A positive result indicates increased susceptibility, not a guaranteed diagnosis. It warrants referral to a pediatric surgeon and genetic counselor for further evaluation and cascade testing of at-risk relatives.
5. How long does it take to receive results?
The turnaround time is 3 to 4 weeks from sample receipt. Results are delivered electronically with a telephonic consultation to discuss findings and next steps.
UAE Regulatory & Data Privacy Adherence
✅ Legal & Compliance Framework
All genetic testing procedures comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for the secure handling of genomic data, and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for digital health record management. Patient consent and clinical safety protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory operates under DHA Facility License No. 1143 and is ISO 9001:2015 accredited.
Clinical & Logistical Metadata
| Test Name | GDNF Gene Hirschsprung Disease Type 3 Susceptibility Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Blood, Extracted DNA, or FTA Card (Buccal Swab) |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene coding region and splice sites |
| ICD-10-CM Code | Q43.1 |
| LOINC Code | 21636-6 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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