Test Price
2,800 AEDโ Home Collection Available
ARL6IP1 Gene SPG61 Genetic Test (NGS) in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Post-Test Telephonic Clinical Guidance on result interpretation and genetic counseling.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
This ARL6IP1 gene sequencing test provides definitive genetic confirmation for hereditary spastic paraplegia type 61 (SPG61), enabling personalized neurological management and family risk assessment. The test utilizes next-generation sequencing technology with full gene coverage to detect pathogenic variants associated with autosomal recessive SPG61.
Test Overview & Methodology
The ARL6IP1 gene encodes a protein critical for endoplasmic reticulum function and neuronal maintenance. Pathogenic mutations in ARL6IP1 cause SPG61, a progressive neurodegenerative disorder characterized by lower limb spasticity and weakness. This NGS-based test provides comprehensive coverage of all coding exons and flanking intronic regions, delivering high-confidence variant detection for clinical decision-making.
| Feature | Our Test (ISO Certified) | Closest Alternative |
|---|---|---|
| Precision | 99.9% Sensitivity & Specificity via NGS | 80-90% with targeted genotyping / WES |
| Methodology | Next-Generation Sequencing (NGS) โ Full gene coverage | Sanger sequencing (single exon), WES (incomplete coverage) |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics, I emphasize that this genetic test is a critical component of the diagnostic workup for hereditary spastic paraplegia. Results must be integrated with clinical findings, family history, and neurological assessment. A negative result does not exclude other genetic subtypes, and comprehensive genetic counseling is recommended for all patients." โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Precautions
Do not discontinue any prescribed medication or modify treatment plans without consulting your physician. This genetic test provides diagnostic information and does not replace regular neurological follow-up or imaging studies. All clinical decisions should be made in conjunction with your healthcare provider.
Exclusion Criteria & Safety Red Flags
- Patients with active infections or febrile illness; sample collection should be deferred.
- Individuals unable to provide informed consent (requires legal guardian).
- ER Red Flags: Sudden onset severe weakness, respiratory distress, or loss of bladder/bowel control demand immediate emergency evaluation.
Patient FAQ & Clinical Guidance
1. What is the ARL6IP1 Gene SPG61 NGS Test and why is it performed?
This test sequences the ARL6IP1 gene to confirm hereditary spastic paraplegia type 61, enabling precise diagnosis and personalized treatment plans for progressive leg stiffness and weakness. The ARL6IP1 gene provides instructions for a protein involved in neuronal function; mutations cause SPG61, a form of autosomal recessive hereditary spastic paraplegia. The test is recommended for patients with clinical symptoms, positive family history, or carrier screening. Early genetic diagnosis facilitates tailored physiotherapy, spasticity management, and genetic counseling for family members.
2. How is the sample collected and what is the turnaround time?
A simple blood draw or FTA card sample is collected; results are available in 3 to 4 weeks via secure online portal. Our ISO-certified VIP mobile phlebotomy service brings hospital-grade blood collection to your doorstep using temperature-controlled cold-chain transport. The 3-4 week turnaround time includes comprehensive bioinformatics interpretation and variant classification. You will receive an email notification when your results are ready, with an option for telephonic clinical guidance from our genetics team.
3. Is this test covered by insurance in the UAE and what laws protect my genetic data?
Many UAE insurers cover genetic testing for neurological disorders; we verify coverage directly via WhatsApp at +971 54 548 8731. Your genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Our laboratory is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139), ensuring compliant handling of sensitive information. You may request data deletion in accordance with applicable regulations.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates under DHA Facility License No. 1143 and complies with all applicable UAE federal regulations governing genetic testing and patient data protection. Your genetic information is processed in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE maintains ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) for quality management systems.
Clinical & Logistical Metadata
| Test Name | ARL6IP1 Gene SPG61 Genetic Test (Next-Generation Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage |
| ICD-10-CM Code | G11.4 |
| LOINC Code | 81409-9 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians