Test Price
2,800 AED✅ Home Collection Available
LAMA3 Gene Sequencing for Generalized Atrophic Benign Epidermolysis Bullosa (Junctional EB) in UAE | 2800 AED | Certified DHA Facility
Executive Summary & Core Metrics
Summary
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) across Dubai, Abu Dhabi, and Sharjah.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation with Consultant Medical Genetics Lina Osama Zaki Quteineh (DHA ID: 9294403).
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced molecular test utilises Next Generation Sequencing (NGS) on the Illumina® platform to interrogate the entire coding region of the LAMA3 gene. It identifies single nucleotide variants, small insertions, and deletions linked to generalized atrophic benign epidermolysis bullosa, a mild junctional EB subtype. Accurate molecular confirmation enables early clinical management, carrier testing, and recurrence risk assessment.
| Feature | Our LAMA3 NGS Test | Closest Alternative (Targeted Sanger Sequencing / Clinical Diagnosis) |
|---|---|---|
| Precision | 99.9% sensitivity for single nucleotide variants, small indels across entire coding region | ~95% sensitivity, only targeted known mutation hotspots |
| Method | Next Generation Sequencing (Illumina® platform) with bioinformatic confirmation | Sanger sequencing of limited exons or clinical observation alone |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks (Sanger) / Immediate clinical suspicion only |
Physician Insight & Safety Protocols
“While this NGS assay provides definitive molecular confirmation of LAMA3-related junctional EB, clinical correlation by a dermatologist and geneticist remains paramount. I advise all patients to combine genetic results with a thorough skin fragility assessment. Genetic counselling is mandatory to interpret inheritance patterns and reproductive options.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Exclusion Criteria & ER Red Flags
- Do not undergo testing if you have a severe active skin infection or sepsis requiring urgent care.
- Minors must have a court-appointed guardian’s consent as per Federal Decree-Law No. 41 of 2021 on personal data; genetic counselling is mandatory prior to testing for all minors.
- This test is not a substitute for emergency wound management; if you experience sudden worsening blisters with fever, shortness of breath, or swallowing difficulty, seek immediate emergency care.
- Recent blood transfusion (< 2 weeks) may interfere with DNA integrity when using whole blood; discuss with our genetic counsellor for alternative sample collection (bucal swab or FTA card).
Exclusion Criteria & Medication Advisory
Medication Warning: Do not discontinue prescribed medication without consulting your doctor. This genetic test does not replace ongoing dermatological care.
Patient FAQ & Clinical Guidance
1. What does the LAMA3 gene test detect and why is NGS better?
The LAMA3 NGS test detects inherited changes in the entire LAMA3 gene causing generalized atrophic benign epidermolysis bullosa, offering a definitive molecular diagnosis in 3–4 weeks. NGS provides comprehensive coverage, identifying variants that Sanger sequencing might miss.
2. Is a blood sample always required, or can I use a buccal swab?
We accept whole blood, extracted DNA, or one drop of blood on an FTA card; a simple, virtually painless collection is performed by our home phlebotomy team within 60 minutes in Dubai, Abu Dhabi, and Sharjah.
3. Will my insurance cover this genetic test and how do I verify?
Many UAE insurance plans reimburse diagnostic genetic testing for hereditary skin disorders; send a photo of your insurance card via WhatsApp to +971 54 548 8731 for instant pre-approval verification.
4. What is the sample type required for this test?
The preferred sample type is peripheral whole blood (3-5 mL in EDTA tube). Buccal swab or FTA card are acceptable alternatives. All samples are processed via temperature-controlled cold-chain courier.
UAE Regulatory & Data Privacy Adherence
- Data Privacy: All patient data is processed in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Data Protection: Compliant with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Patient Consent & Safety: Clinical testing safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
- DHA License: Operated under DHA Facility License No. 1143.
- Quality Certification: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | LAMA3 Gene Sequencing for Generalized Atrophic Benign Epidermolysis Bullosa |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), Buccal Swab, or FTA Card |
| Methodology Used | Next Generation Sequencing (Illumina® platform) with bioinformatic confirmation |
| ICD-10-CM Code | Q81.9 |
| LOINC Code | 9489-2 |
| DHA Facility License & Address | DHA Facility License No: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
DHA Licensed Facility | ISO 9001:2015 Certified | Results in 3–4 Weeks
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All reports reviewed by DHA-Certified physicians