Test Price
2,800 AEDโ Home Collection Available
EXT2 Gene Exostoses, Multiple, Type 2 Genetic Test in UAE | 2800 AED | DHA-Licensed NGS Diagnostics
Executive Summary & Core Metrics
Executive Summary
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across the UAE.
Clinical Guidance: Telephonic post-test genetic counselling by DHA-licensed consultant medical geneticists for result interpretation.
Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The EXT2 Gene Exostoses, Multiple, Type 2 Genetic Test screens for pathogenic variants in the EXT2 gene using next-generation sequencing, definitively diagnosing hereditary multiple exostoses (HME). With comprehensive CNV detection and a 3- to 4-week turnaround, this assay provides families with actionable clinical clarity and guides orthopedic surveillance protocols.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity (NGS, full gene coverage) | ~95% by targeted mutation panels |
| Methodology | Next Generation Sequencing (NGS) with CNV detection | Sanger sequencing or limited multiplex ligation |
| Speed | 3โ4 Weeks, cold-chain logistics | 6โ8 Weeks in non-specialized centers |
Bioinformatics pipelines validated against ClinVar and gnomAD population databases.
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh โ Consultant Medical Genetics (DHA: 9294403)
โA positive EXT2 result confirms a hereditary bone disorder that mandates lifelong orthopedic surveillance. However, a negative result does not exclude other genetic or acquired causes of exostoses; clinical correlation with imaging and three-generation pedigree analysis remains essential. I advise all patients to review their results within a multidisciplinary team including a clinical geneticist and orthopedic specialist.โ
Important Advisory โ Medication Continuity
Do not alter or discontinue any prescribed treatment without consulting your physician. Genetic findings complement but never replace ongoing clinical management or medication regimens.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inadequate or degraded DNA samples (less than 1 ยตg or contaminated).
- Exclusion: Individuals unwilling to complete a three-generation pedigree during mandatory genetic counselling.
- Red Flag โ Seek immediate medical attention: Sudden rapid growth of an existing exostosis, persistent pain, or neurological deficit (numbness or weakness).
- Red Flag: New cartilaginous cap thickening exceeding 2 cm in adults on surveillance imaging.
Patient FAQ & Clinical Guidance
1. What is the diagnostic accuracy of the EXT2 gene test for hereditary multiple exostoses?
A: This NGS assay delivers over 99.9% diagnostic sensitivity for pathogenic EXT2 variants when performed on a high-quality blood or DNA sample. It detects point mutations, small insertions and deletions, and copy number variations, providing a comprehensive molecular diagnosis.
2. How long does it take to receive test results?
A: Results are typically available within 3 to 4 weeks after the laboratory receives an optimal specimen. Sample tracking updates are available via WhatsApp during the processing period.
3. Is pre-test genetic counselling mandatory before ordering this test?
A: Yes, a DHA-compliant pre-test genetic counselling session and a detailed three-generation pedigree chart are mandatory to ensure appropriate test selection, informed consent, and accurate interpretation in accordance with UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
4. What sample types are accepted and how should they be transported?
A: Accepted specimen types include whole blood in EDTA tubes, extracted DNA (minimum 1 ยตg), or a single blood spot on an FTA card. Blood tubes require cold-chain transport; FTA cards remain stable at room temperature and comply with ISO-certified logistics protocols.
5. What clinical information is required before the test can be performed?
A: A complete clinical history documenting the indication for hereditary multiple exostoses, a three-generation pedigree chart obtained during genetic counselling, and signed informed consent that complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) are all required prior to sample collection.
All answers reviewed by DHA-licensed consultant medical geneticists. For urgent inquiries, contact WhatsApp +971 54 548 8731 (8 AM โ 11 PM).
UAE Regulatory & Data Privacy Adherence
Trust & Compliance Framework
ISO 9001:2015 Certified โ Certificate INT/EGQ/2509DA/3139. Facility licensed by the Dubai Health Authority (DHA License: 1143). All genetic testing services comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted and stored on secure local servers with restricted access.
Important: This test is performed for genetic diagnostic purposes and requires a physicianโs referral. Results must be interpreted by a clinical geneticist or orthopedic specialist. For emergency clinical correlation, contact your primary physician or emergency services immediately.
Clinical & Logistical Metadata
| Test Name | EXT2 Gene Exostoses, Multiple, Type 2 Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 weeks from sample receipt |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA (≥1 ยตg), or FTA card blood spot โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM โ 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) with full gene coverage and CNV detection |
| ICD-10-CM Code | Q78.6 (Multiple congenital exostoses โ hereditary multiple exostoses) |
| LOINC Code | 91869-4 (EXT2 gene mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Address | License: 1143 • Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE • DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians