DSG4 Gene Hypotrichosis Type 6 Genetic Test in UAE | 2,800 AED | DHA Licensed Lab

Executive Summary & Core Metrics

This advanced Next-Generation Sequencing (NGS) genetic test provides a definitive molecular diagnosis for hypotrichosis type 6 caused by pathogenic variants in the DSG4 gene. The test operates under strict ISO 9001:2015 quality management protocols (Cert: INT/EGQ/2509DA/3139).

🔬 Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing.
🏠 Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
🧑‍⚕️ Clinical Guidance: Telephonic Post-Test Clinical Guidance by DHA-licensed specialists for result interpretation.
💳 Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

The DSG4 Gene Hypotrichosis Type 6 Genetic Test identifies pathogenic variants in the DSG4 gene, the definitive cause of autosomal recessive hypotrichosis type 6 – a condition marked by sparse, fragile hair from infancy. Our next‑generation sequencing (NGS) technology examines all coding regions and splice sites with ≥100x read depth, providing a molecular diagnosis and guiding dermatological, genetic, and reproductive counseling.

Feature	Our Test (DSG4 NGS)	Alternative (Clinical Exam Only)
Diagnostic Precision	Mutation-specific identification with 99.9% sensitivity	Phenotypic suspicion; often misdiagnosed as monilethrix or alopecia areata
Methodology	Illumina® NGS (Next Generation Sequencing) + Bioinformatic Analysis	Visual inspection, trichoscopy
Turnaround Time	3 to 4 Weeks	Immediate (but non-definitive)

Physician Insight & Safety Protocols

"The DSG4 gene encodes desmoglein 4, a critical protein for hair shaft integrity. Identifying bi-allelic pathogenic variants in this gene provides a definitive diagnosis for families navigating congenital hypotrichosis. It allows for precise genetic counseling and distinguishes this condition from other ectodermal dysplasias. Correlation with clinical findings remains essential." — Dr. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA ID: 9294403

Clinical Advisory & Safety Protocols

Patients must not discontinue any prescribed medication based solely on genetic test results without consulting their primary care physician or dermatologist.

Informed consent is mandatory per Federal Decree-Law No. 4 of 2016 on Medical Liability; guardians must provide consent for minors.
Standard venipuncture precautions apply for blood-draw based testing.

Safety Exclusion Criteria & Emergency Red Flags

Inability to provide informed consent.
Severe anemia or bleeding disorder that contraindicates venipuncture.
Known allergy to antiseptic or latex used in collection kit – alert our phlebotomy team.
Red Flags: Rapid progression of hair loss with systemic symptoms (fever, weight loss) demands urgent dermatology evaluation; do not delay care for genetic results.

Patient FAQ & Clinical Guidance

1. What exactly does the DSG4 gene test diagnose?

The test definitively identifies pathogenic mutations in the DSG4 gene responsible for autosomal recessive hypotrichosis type 6, a rare form of congenital sparse, fragile, and short hair that often appears in infancy or early childhood. It distinguishes this condition from other forms of alopecia and ectodermal dysplasias.

2. How is the sample collected for this genetic test?

We utilize a pain-minimizing approach using a standard peripheral whole blood draw (3-5 mL) performed by a specialist phlebotomist. Alternatively, a buccal swab can be accepted for DNA extraction. All collections follow strict ISO cold-chain protocols to ensure sample integrity. Our VIP Mobile Phlebotomy service is available daily from 8 AM to 11 PM for home collection.

3. Will my UAE health insurance cover this genetic test?

Coverage varies by policy. Our team verifies direct billing eligibility via WhatsApp +971 54 548 8731 and provides a pre-authorization assistance letter referencing DHA-mandated ICD-10-CM code Q84.1 and relevant LOINC codes.

UAE Regulatory & Data Privacy Adherence

DNA Labs UAE is fully compliant with the highest federal standards for clinical data security and patient privacy. All genetic data generated by this test is handled in strict accordance with:

Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the collection, processing, and transfer of personal health data.
Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – ensuring the security and confidentiality of digital health records.
Federal Decree-Law No. 4 of 2016 on Medical Liability – defining the ethical and legal obligations for patient consent and clinical practice.

Results are released only to the ordering physician and patient upon verified identity, ensuring full audit trail compliance.

Clinical & Logistical Metadata

Test Name	DSG4 Gene Hypotrichosis Type 6 Genetic Test (NGS)
Price (AED)	2,800
Turnaround Time	3 to 4 Weeks
Sample Type	Peripheral Whole Blood (3-5 mL) or Buccal Swab; Acceptable: Extracted DNA
Methodology Used	Next-Generation Sequencing (NGS) – Full Gene Coding Regions & Splice Sites
ICD-10-CM Code	Q84.1
LOINC Code	74048-8
DHA Facility License & Address	Facility License No. 1143 \| DNA Labs UAE \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE

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