Test Price
2,800 AED✅ Home Collection Available
ATP8B1 Gene Intrahepatic Cholestasis of Pregnancy Type 1 (ICP1) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين ATP8B1 لكولستاسيس الحمل داخل الكبد النوع الأول (ICP1) بتقنية NGS في الإمارات | 2800 درهم | إرشادات هيئة الصحة بدبي 2026
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing with comprehensive coverage of all ATP8B1 coding regions and splice sites.
Premium Logistics: Paid Hospital‑Grade Home Collection with ISO Certified Cold‑Chain Home Collection and VIP Mobile Phlebotomy (8 AM–11 PM, 7 days a week).
Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation by our genetic counsellors, ensuring seamless integration with your obstetrician’s care plan.
Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731 — confirm your coverage in under 5 minutes.
ضمان الدقة: حساسية تشخيصية بنسبة 99.9% عبر تسلسل جيني متطور معتمد من ISO 9001:2015 و يغطي كافة مناطق جين ATP8B1.
خدمة لوجستية متميزة: سحب منزلي مأجور بمعايير النقل البارد المعتمدة ISO و فريق تمريض متنقل (8 صباحاً – 11 مساءً، طوال أيام الأسبوع).
الإرشاد السريري: استشارة هاتفية بعد النتيجة لتفسير النتائج بالتنسيق مع طبيبك المختص.
التأمين: توثيق مباشر للتغطية عبر واتساب +971 54 548 8731 — تأكيد تغطيتك خلال 5 دقائق.
Overview
The ATP8B1 gene test is a next‑generation sequencing (NGS) analysis that detects pathogenic variants linked to progressive familial intrahepatic cholestasis type 1 (PFIC1) and intrahepatic cholestasis of pregnancy type 1. This comprehensive molecular evaluation empowers obstetricians, gynecologists, and gastroenterologists to confirm genetic susceptibility, guide pregnancy management, and assess familial risk with 99.9% diagnostic sensitivity. (تحليل جيني متطور يؤكد القابلية الوراثية لكولستاسيس الحمل داخل الكبد بدقة فائقة ويدعم القرارات السريرية.)
| Feature | Our Test (NGS – ICP1 Full Gene) | Closest Alternative (Standard PCR Panel) |
|---|---|---|
| Precision | >99.9% analytical sensitivity; detects single‑nucleotide variants, indels, and copy‑number changes | ~95% sensitivity; limited to a few common mutations; misses rare variants |
| Method | NGS (Next Generation Sequencing) with verified bioinformatics pipeline & DHA/MOHAP‑compliant interpretation | Allele‑specific PCR or Sanger sequencing of hotspots |
| Turnaround Time | 3 to 4 Weeks | 2 to 4 Weeks (often with reflex to NGS if negative) |
| Price | 2800 AED | 2200–2600 AED (incomplete analysis) |
Physician Insight & Safety Protocol
Dr. PRABHAKAR REDDY (DHA License: 61713011):
“I understand how worrying hereditary pregnancy complications can be. This test offers a definitive genetic answer, yet a variant’s impact depends on your overall clinical picture—liver enzymes, bile acids, and family history. Results must be interpreted together with your obstetrician, not as a standalone verdict. A negative result does not rule out non‑genetic ICP, and a positive result empowers proactive monitoring.”
⚠️ Medication and Clinical Warning:
Do not discontinue prescribed medication (especially ursodeoxycholic acid, antihistamines, or prenatal vitamins) without consulting your doctor. Fasting or dietary changes are not required for this DNA test, but follow your obstetrician’s guidance for any concurrent blood work.
Exclusion Criteria & Emergency Red Flags
- Exclusion conditions for sample collection: Known hematological disorders (e.g., severe thrombocytopenia, hemophilia) unless cleared by your physician; acute skin infection at the phlebotomy site.
- Emergency Symptoms – seek immediate medical attention: New‑onset severe pruritus (itching, especially palms and soles), jaundice (yellowing of skin/eyes), dark urine, or right upper quadrant pain during pregnancy. These may indicate acute intrahepatic cholestasis requiring urgent obstetric care, regardless of genetic results.
Patient FAQ & Clinical Guidance
1. What is the ATP8B1 genetic test, and how does it help in pregnancy?
This full‑gene NGS test identifies inherited changes in the ATP8B1 gene that cause intrahepatic cholestasis of pregnancy, allowing your doctor to monitor you closely and prevent complications like preterm birth. (هذا الاختبار الجيني الشامل يكشف الطفرات الوراثية المسؤولة عن كولستاسيس الحمل، مما يمكّن الطبيب من المتابعة الدقيقة وتجنب المضاعفات.)
2. Who should get tested for ATP8B1‑related intrahepatic cholestasis of pregnancy?
Women with personal or family history of severe pregnancy itching, elevated bile acids, or diagnosed ICP should consider testing, ideally paired with genetic counselling to assess recurrence risk. (النساء اللواتي لديهن تاريخ شخصي أو عائلي لحكة حمل شديدة أو ارتفاع أحماض الصفراء يُنصح لهن بالفحص مع استشارة وراثية.)
3. How accurate is this DNA, and will it change my pregnancy management?
With >99.9% analytical sensitivity, a positive result confirms genetic predisposition to ICP and triggers tailored monitoring (serial bile acids, non‑stress tests) even before symptoms appear. (بدقة تتجاوز 99.9%، تؤكد النتيجة الإيجابية القابلية الوراثية وتستدعي متابعة مخصصة حتى قبل ظهور الأعراض.)
All clinical guidance aligns with Federal Decree‑Law No. 41 of 2024 (Art. 87), CDS Law 2026 (genetic testing for minors requires parental consent), and UAE PDPL for data privacy. Our laboratory holds ISO 9001:2015 Certification INT/EGQ/2509DA/3139.
DHA/MOHAP Standard Nomenclature: ATP8B1 gene full sequence analysis – ICP1. All services performed by licensed facility MOHAP License No. 9834453. 2026 ICD‑10‑CM Codes: O26.619, Z14.8, Z31.430; LOINC: 10118‑6 (loinc.org/10118-6). WhatsApp support: +971 54 548 8731
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