Test Price
2,800 AED✅ Home Collection Available
ATP8B1 Gene Intrahepatic Cholestasis of Pregnancy (ICP1) Genetic Test | DNA Labs UAE | 2,800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing with comprehensive coverage of all ATP8B1 coding regions and splice sites.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM–11 PM, 7 days a week).
Clinical Guidance: Post-test genetic counselling consultation with our Consultant in Medical Genetics to integrate results with your obstetric care plan.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731 — confirm your coverage in under 5 minutes.
Test Overview & Methodology
The ATP8B1 gene test uses next‑generation sequencing (NGS) to detect pathogenic variants associated with progressive familial intrahepatic cholestasis type 1 (PFIC1) and intrahepatic cholestasis of pregnancy type 1 (ICP1). This molecular evaluation empowers obstetricians, gynecologists, and gastroenterologists to confirm genetic susceptibility, guide pregnancy management, and assess familial risk with 99.9% diagnostic sensitivity.
| Feature | Our Test (NGS – ATP8B1 Full Gene) | Closest Alternative (Standard PCR Panel) |
|---|---|---|
| Precision | >99.9% analytical sensitivity; detects single‑nucleotide variants, indels, and copy‑number changes | ~95% sensitivity; limited to a few common mutations; misses rare variants |
| Method | NGS (Next Generation Sequencing) with verified bioinformatics pipeline and DHA/MOHAP‑compliant interpretation | Allele‑specific PCR or Sanger sequencing of hotspots |
| Turnaround Time | 3 to 4 Weeks | 2 to 4 Weeks (often with reflex to NGS if negative) |
| Price | 2,800 AED | 2,200–2,600 AED (incomplete analysis) |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh (Consultant Medical Genetics | DHA Registration ID: 9294403):
“This genetic test offers a definitive molecular answer for susceptibility to intrahepatic cholestasis of pregnancy. However, a variant’s clinical impact must be assessed together with liver enzymes, bile acid levels, and family history. Results should always be interpreted in conjunction with your obstetrician’s full clinical evaluation.”
Medication & Clinical Advisory
Do not discontinue prescribed medication (especially ursodeoxycholic acid, antihistamines, or prenatal vitamins) without consulting your doctor. Fasting or dietary changes are not required for this DNA test, but follow your obstetrician’s guidance for any concurrent blood work. All clinical testing adheres to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Exclusion Criteria & Emergency Red Flags
- Exclusion conditions for sample collection: Known hematological disorders (e.g., severe thrombocytopenia, hemophilia) unless cleared by your physician; acute skin infection at the phlebotomy site.
- Emergency Symptoms – seek immediate medical attention: New‑onset severe pruritus (itching, especially palms and soles), jaundice (yellowing of skin/eyes), dark urine, or right upper quadrant pain during pregnancy. These may indicate acute intrahepatic cholestasis requiring urgent obstetric care, regardless of genetic results.
Patient FAQ & Clinical Guidance
1. What is the ATP8B1 genetic test, and how does it help in pregnancy?
This full‑gene NGS test identifies inherited changes in the ATP8B1 gene that cause intrahepatic cholestasis of pregnancy, allowing your doctor to monitor you closely and prevent complications like preterm birth. The test is performed on a simple blood sample.
2. Who should get tested for ATP8B1‑related intrahepatic cholestasis of pregnancy?
Women with personal or family history of severe pregnancy itching, elevated bile acids, or diagnosed ICP should consider testing, ideally paired with genetic counselling to assess recurrence risk and inform family planning.
3. How accurate is this test, and will it change my pregnancy management?
With >99.9% analytical sensitivity, a positive result confirms genetic predisposition to ICP and triggers tailored monitoring (serial bile acids, non‑stress tests) even before symptoms appear. A negative result reduces but does not eliminate the possibility of non‑genetic ICP.
UAE Regulatory & Data Privacy Adherence
Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): Your genetic data is processed and stored under strict confidentiality safeguards.
Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: All digital health records and electronic communication adhere to this framework.
DHA Facility License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. All services are provided by DNA Labs UAE under the regulatory oversight of the Dubai Health Authority.
Clinical & Logistical Metadata
| Test Name | ATP8B1 Gene Intrahepatic Cholestasis of Pregnancy (ICP1) Genetic Test – NGS Full Gene Analysis |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral Venous Blood) |
| Methodology Used | Next‑Generation Sequencing (NGS) with bioinformatics analysis |
| ICD-10-CM Code | O26.619, Z14.8, Z31.430 |
| LOINC Code | 10118-6 |
| DHA Facility License & Address | 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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