TP53 Gene (Li-Fraumeni Syndrome) Genetic Test in UAE – 2,800 AED

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing.

Premium Logistics: Hospital-grade home collection with ISO certified cold-chain transport and VIP mobile phlebotomy (available daily 8 AM – 11 PM).

Clinical Guidance: Complimentary telephonic post-test clinical guidance with a medical geneticist.

Insurance: Direct billing verification via WhatsApp +971 54 548 8731.

Test Overview & Methodology

This advanced next‑generation sequencing (NGS) test screens the entire coding region of the TP53 tumor suppressor gene for germline pathogenic variants linked to Li‑Fraumeni syndrome – a rare autosomal dominant condition that elevates lifetime cancer risk to over 90%.

Comparative Advantage

Feature	Our Test (DNA Labs UAE)	Closest Alternative (Standard Labs)
Methodology	Full‑gene NGS with copy number variation analysis	Targeted Sanger sequencing, limited coverage
Diagnostic Yield	>99.9% sensitivity for known pathogenic variants	~95% sensitivity; may miss large deletions/duplications
Turnaround Time	3–4 weeks from sample receipt	4–6 weeks
Cost (AED)	2,800	3,200 – 3,800
Pre‑test Genetic Counseling	Included (mandatory session)	Often optional, additional cost

Physician Insight & Safety Protocols

“While this test provides exceptional sensitivity for TP53 mutations, it must be integrated with a detailed family pedigree and clinical evaluation. A positive result indicates inherited susceptibility, not a cancer diagnosis, and empowers tailored screening strategies. Always remember, your health journey is a partnership between you and your physician.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Advisory Guidance

Medication Warning: Do not discontinue prescribed medication without consulting your doctor. Always inform your geneticist and primary care provider about any concurrent treatments before sample collection.

Pre‑test Counseling: A mandatory pre‑test genetic counseling session is included to discuss inheritance patterns, implications for family members, and psychosocial considerations.

Exclusion Criteria & Emergency Red Flags

Exclusion Criteria: Individuals unable to provide informed consent (legal guardian required), acute febrile illness, active severe infection.
Emergency Red Flags: If you experience unexplained weight loss, hemoptysis, seizures, sudden visual changes, or severe pain, seek immediate medical attention regardless of test status.

Patient FAQ & Clinical Guidance

1. How long does the TP53 gene test take?

TP53 gene NGS test results are reported within 3 to 4 weeks, ensuring comprehensive genomic interpretation.

2. What does a positive TP53 variant mean?

A positive TP53 pathogenic variant signifies Li‑Fraumeni syndrome with increased cancer susceptibility; discuss with an oncologist and genetic counselor.

3. Is genetic counseling required before testing?

Pre‑test genetic counseling is mandatory to explain TP53 implications, review family medical history, and discuss potential outcomes. The session is included in the test cost.

UAE Regulatory & Data Privacy Adherence

Data Protection: All genetic data is handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.

Clinical Safety: Patient consent and clinical safety follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Results are reported only after independent verification by a board‑certified molecular pathologist.

Clinical & Logistical Metadata

Test Name	TP53 Gene (Li‑Fraumeni Syndrome) Genetic Test
Price (AED)	2,800
Turnaround Time	3–4 weeks (21–28 calendar days)
Sample Type / Matrix	Peripheral Whole Blood (EDTA) – VIP Mobile Phlebotomy Available Daily 8 AM – 11 PM
Methodology Used	Next‑Generation Sequencing (NGS) – Full Gene Coverage with CNV Analysis
ICD‑10‑CM Code	Z15.09 (Genetic susceptibility to other malignant neoplasm)
LOINC Code	21636-6 (TP53 gene mutation analysis)
DHA Facility License & Laboratory Address	DHA License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Corporate Lab Branding: DNA Labs UAE