Test Price
10,000 AED✅ Home Collection Available
Hepatitis C Viral RNA Genotype 1 NS5A Drug Resistance Test
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189:2022 Certified Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Compliance: Federal Decree-Law No. 45 of 2021 (PDPL), Federal Law No. 2 of 2019, Federal Decree-Law No. 4 of 2016.
- Facility License: 1143
- Corporate Lab: DNA Labs UAE
Test Overview & Methodology
This advanced molecular test detects Hepatitis C Virus (HCV) Genotype 1 NS5A drug resistance-associated substitutions (RASs) using Next-Generation Sequencing (NGS) and PCR, guiding personalized Direct-Acting Antiviral (DAA) therapy.
| Feature | Our Test | Closest Alternative (Standard HCV RNA) |
|---|---|---|
| Precision | NGS/PCR detects all clinically significant NS5A RASs with >99.9% analytical sensitivity | Only quantifies HCV RNA; no resistance data |
| Methodology | PCR + Next-Generation Sequencing (NGS) with bioinformatics alignment | Real-time PCR (qPCR) for viral load only |
| Speed & TAT | Sample by 7th of month; Report after 2–3 weeks | Usually 1–3 days for viral load; no resistance report |
Physician Insight & Safety Protocols
“This test identifies resistance mutations that may compromise NS5A inhibitors such as ledipasvir and velpatasvir. Results must always be interpreted alongside quantitative viral load and hepatic function markers. Therapeutic adjustments should never be made without full clinical correlation. A comprehensive evaluation by your treating hepatologist remains essential for safe and effective management.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Clinical Advisory
Do not modify or discontinue prescribed antiviral therapy without explicit consultation with your treating hepatologist. Treatment decisions must integrate resistance profiling with full clinical context including fibrosis stage and viral load.
Exclusion Criteria & ER Red Flags
- Active decompensated cirrhosis (ascites, variceal hemorrhage, hepatic encephalopathy) — seek emergency care immediately.
- Severe acute hepatitis with transaminases exceeding 10× the upper limit of normal.
- Pregnancy or lactation — discuss maternal-fetal transmission risks with your obstetrician.
- Known HIV or HBV co-infection requiring multidisciplinary management.
- Samples not collected and transported under strict temperature-controlled conditions may yield invalid results.
Patient FAQ & Clinical Guidance
1. What exactly does the Hepatitis C NS5A drug resistance test detect, and why is it critical before starting DAA treatment?
It detects NS5A resistance-associated substitutions that can reduce the efficacy of direct-acting antivirals like ledipasvir and velpatasvir, guiding optimal therapy selection.
2. How should I prepare for sample collection, and is home phlebotomy available?
No special preparation is required. Our VIP mobile phlebotomy service provides temperature-controlled cold-chain collection at your location, available daily from 8 AM to 11 PM with a signed consent form.
3. What happens if a resistance mutation is found — will I need to change my medication?
Your hepatologist will adjust therapy based on the resistance profile, which may involve combining an NS5A inhibitor with other DAAs or switching to an alternative regimen. Never alter medication without medical guidance.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with UAE federal data protection and health information governance frameworks. Patient data is safeguarded under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. All laboratory processes adhere to ISO 15189:2022 standards for quality and competence.
Clinical & Logistical Metadata
| Test Name | Hepatitis C Viral RNA Genotype 1 NS5A Drug Resistance Test |
| Price (AED) | 10,000 |
| Turnaround Time | 2–3 Weeks |
| Sample Type / Matrix | Blood (Serum / Plasma) |
| Methodology Used | PCR + Next-Generation Sequencing (NGS) with Bioinformatics Alignment |
| ICD-10-CM Code | B18.2, Z16.23 |
| LOINC Code | 78525-7 |
| DHA Facility License & Laboratory Address | Facility License 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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