Test Price
2,800 AED✅ Home Collection Available
NHS Gene Cataract, X‑linked Genetic Test in UAE | 2800 AED | DHA Accredited
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across the UAE.
Clinical Guidance: Post-test telephonic genetic counselling session with result interpretation provided by our Consultant Medical Genetics.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test screens the entire coding region of the NHS gene to confirm or exclude pathogenic variants associated with Nance‑Horan syndrome, an X‑linked disorder characterized by congenital cataract, dental anomalies, and intellectual disability. Prior to sample collection, a complete clinical history including age at cataract onset, extra‑ocular features, and a three‑generation pedigree must be submitted. A mandatory pre‑test genetic counselling session will be scheduled to review the scope, possible outcomes, and implications for at‑risk family members. Fasting is not required, but patients on anticoagulants must inform the phlebotomist.
| Feature | Our Test (DHA/MOHAP Standard) | Closest Alternative (Sanger / WES) |
|---|---|---|
| Precision | 99.9% sensitivity for single‑nucleotide, indel, copy‑number changes | ~95% sensitivity; may miss deep intronic or mosaic variants |
| Method | Targeted NGS (Illumina® platform) with complete gene coverage | Sanger sequencing (single‑exon) or whole‑exome with gap risk |
| Turnaround | 3–4 weeks from sample receipt | 6–12 weeks (WES); 4–6 weeks (Sanger) |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasize that a genetic result alone does not define a patient’s future. An NHS variant must be interpreted alongside a full ophthalmic and systemic evaluation. I encourage families to use this test as a compass, not a verdict, and to discuss all findings with their treating ophthalmologist and genetic counsellor.” – Lina Osama Zaki Quteineh, DHA Registration ID: 9294403.
Safety Advisory & Precautions
⚠️ Important Medication Note
Do not alter or stop any prescribed medications or eye drops without explicit instruction from your consultant. Genetic testing does not replace ongoing clinical care. Always consult your physician before making changes to your treatment regimen.
Exclusion Criteria & Emergency Red Flags
- Inability to provide a clinical history or three‑generation pedigree chart.
- Severe haemolysis, clotted specimen, or insufficient DNA yield.
- Active anticoagulation above therapeutic range – sample collection deferred.
- Patient unwilling to attend mandatory pre‑test genetic counselling session.
🔴 If you experience sudden vision loss, intense eye pain, flashes of light, or severe headache after sample collection, seek emergency ophthalmologic care immediately.
Patient FAQ & Clinical Guidance
1. How accurate is the NHS gene test for diagnosing Nance‑Horan syndrome?
Snippet: With 99.9% analytical sensitivity, our NGS test reliably identifies single‑nucleotide variants and copy‑number changes across all coding exons of the NHS gene.
2. What sample type is required and how is the home collection performed?
Snippet: We accept whole blood (EDTA/NaCitrate), extracted DNA, or a single drop dried on an FTA card. Our VIP Mobile Phlebotomy service collects samples at your home between 8 AM and 11 PM daily, using temperature‑controlled cold‑chain logistics.
3. How should I interpret my results and what are the next steps?
Snippet: A positive result confirms the X‑linked NHS variant, guiding cascade testing in maternal relatives and early cataract management from infancy. Our genetic counsellor will schedule a post‑test telephonic session to explain findings in detail.
UAE Regulatory & Data Privacy Adherence
This genetic test is performed under the oversight of the Dubai Health Authority (DHA) and complies with all applicable UAE data protection and health information regulations. Your genetic data is handled in strict accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to the standards set forth in Federal Decree-Law No. 4 of 2016 on Medical Liability to ensure patient safety and informed consent.
Clinical & Logistical Metadata
| Test Name | NHS Gene (Nance‑Horan Syndrome) Targeted NGS Analysis |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks from sample receipt |
| Sample Type / Matrix | Whole Blood (EDTA/NaCitrate), Extracted DNA, or FTA Card |
| Methodology Used | Targeted Next‑Generation Sequencing (NGS) on Illumina® platform |
| ICD-10-CM Code | Q12.0 (Congenital cataract) |
| LOINC Code | 57998-1 (NHS gene mutation analysis) |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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