Test Price
4,800 AED✅ Home Collection Available
Hereditary Spastic Paraplegia Gene Panel in UAE | 4,800 AED
Executive Summary & Core Metrics
Executive Summary
99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS processing. Paid hospital-grade cold-chain home collection with VIP mobile phlebotomy for blood samples; invasive prenatal specimens require hospital extraction. Telephonic post-test clinical guidance with a consultant medical geneticist. Direct insurance billing verification on WhatsApp: +971 54 548 8731. A valid doctor's prescription is required for this genetic test; turnaround time is 4-6 weeks.
Test Overview & Methodology
This next-generation sequencing (NGS) panel screens all known genes associated with hereditary spastic paraplegia (HSP) to identify pathogenic variants causing progressive lower-limb spasticity and gait impairment. It offers unmatched sensitivity for early detection in symptomatic adults, at-risk relatives, and prenatal settings. Accepted sample types include peripheral blood (2 × EDTA tubes) for standard collection, and amniotic fluid or chorionic villi for prenatal diagnosis.
| Feature | Our NGS Gene Panel | Closest Alternative Single-Gene Sanger |
|---|---|---|
| Precision | Greater than 99.9% analytical sensitivity for all HSP genes | High accuracy but only one gene at a time |
| Method | Illumina NovaSeq NGS with full bioinformatics pipeline | Capillary Sanger sequencing |
| Coverage and Speed | All exons of 40 plus genes concurrently result in 4 to 6 weeks | Sequential single-gene testing cumulative 12 to 16 weeks |
Physician Insight & Safety Protocols
As a consultant medical geneticist, I emphasize that a positive result reveals the hereditary pattern but must always be correlated with neurological examination and imaging. A negative panel does not exclude HSP if hallmark signs persist, warranting further genetic exploration. Patients should never discontinue prescribed antispastic medications without specialist review.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
Do not discontinue prescribed medication such as baclofen, tizanidine, or botulinum toxin without consulting your physician. This gene panel is a diagnostic aid and does not replace clinical management. Always maintain your current treatment regimen until directed otherwise by your treating specialist.
Exclusion Criteria & Immediate Red Flags
- Sample collection not performed by our DHA-licensed phlebotomists or at an approved hospital facility for invasive specimens.
- Unlabelled or clotted EDTA tubes; sample transport breaches 2 to 8 degree Celsius cold chain.
- Clinical emergency signs such as sudden paraplegia, acute visual loss, or severe dysphagia proceed directly to the ER, not a scheduled home draw.
Patient FAQ & Clinical Guidance
1. What does the Hereditary Spastic Paraplegia Gene Panel detect, and how accurate is it?
Snippet Answer: Using next-generation sequencing, this panel detects pathogenic variants in over 40 HSP-linked genes with 99.9% analytical sensitivity, confirming autosomal dominant, recessive, or X-linked inheritance patterns. This comprehensive approach provides a definitive molecular diagnosis for the majority of hereditary spastic paraplegia cases.
2. How is the sample collected, and is home service available in the UAE?
Snippet Answer: For peripheral blood samples, a DHA-licensed phlebotomist arrives at your home or office between 8 AM and 11 PM using ISO-certified cold-chain transport. For invasive prenatal specimens such as amniotic fluid or chorionic villi, collection is performed strictly within an accredited hospital facility. Payment and insurance verification are processed before collection.
3. When should I expect my results, and what happens after I receive them?
Snippet Answer: The full interpretation report is released in 4 to 6 weeks. A complimentary telehealth consultation with a consultant medical geneticist or your referring physician will explain the implications for treatment, family screening, and reproductive options. This post-test counselling ensures you understand the clinical significance of every finding.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates in full compliance with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring all genetic data is securely processed and stored. Additionally, Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields governs the secure handling of electronic health records. Clinical safety and patient consent are protected under Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE maintains strict adherence to these regulations, guaranteeing that every genetic test is performed with the highest standards of data privacy, patient safety, and ethical practice.
Clinical & Logistical Metadata
| Test Name | Hereditary Spastic Paraplegia Gene Panel |
| Price (AED) | 4,800 |
| Turnaround Time | 4 to 6 weeks |
| Sample Type / Matrix | Peripheral blood (2 × EDTA tubes) with VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM. Amniotic fluid and chorionic villi specimens are hospital extraction only; sample collection is conducted strictly within an accredited hospital facility. |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina NovaSeq platform with full bioinformatics pipeline |
| ICD-10-CM Code | G11.4 |
| LOINC Code | 103208-0 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab Branding: DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians