Test Price
2,800 AED✅ Home Collection Available
LGI1 Gene Epilepsy, Familial Temporal Lobe Epilepsy Type 1 – Genetic Test in UAE | AED 2,800 | DHA Licensed
Executive Summary & Core Metrics
Core Metrics
- Diagnostic Accuracy: 99.9% analytical sensitivity via ISO 9001:2015-certified NGS workflow with full exon coverage and CNV detection.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. DHA-licensed nurse administered.
- Specialist Review: Triangulated validation by a Consultant Medical Geneticist, certified genetic counselor, and clinical molecular geneticist ensures diagnostic confidence.
- Clinical Guidance: Complimentary telephonic post-test interpretation by the referring Consultant Medical Geneticist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The LGI1 gene test identifies pathogenic variants linked to autosomal dominant familial temporal lobe epilepsy, enabling precise diagnosis and targeted management. Next-Generation Sequencing ensures comprehensive coverage of all coding regions and intron-exon boundaries, with concurrent copy number variation analysis to detect deletions and duplications that standard sequencing methods miss.
| Feature | Our Test (DNA Labs UAE) | Standard Alternative |
|---|---|---|
| Detection Method | Next Generation Sequencing (NGS) with CNV analysis | Sanger sequencing (single gene, limited variant detection) |
| Analytical Sensitivity | >99.9% (full exon coverage) | ~85% (selected regions only) |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Pre-test Genetic Counseling | Included (complimentary) | Often omitted or charged separately |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant Medical Geneticist, I affirm that this targeted LGI1 gene analysis delivers valuable diagnostic clarity for individuals presenting with clinical features of familial temporal lobe epilepsy. Results must be interpreted in conjunction with electroencephalographic findings, neuroimaging, and a comprehensive neurological evaluation. Patients and families should receive pre- and post-test genetic counseling to fully understand the implications of identified variants. Do not discontinue or adjust any prescribed antiepileptic medication without direct medical supervision. Should a prolonged seizure (status epilepticus) occur, seek emergency medical care without delay.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not stop or adjust any anti-seizure medication based on test results without consulting your treating physician. Abrupt withdrawal of antiepileptic drugs can precipitate severe rebound seizures or status epilepticus.
Exclusion Criteria & Emergency Red Flags
- This test is not a substitute for clinical seizure monitoring, electroencephalography, or brain MRI.
- Minors (<18 years) require judicial or parental consent per Federal Decree-Law No. 4 of 2016 on Medical Liability; predictive testing of asymptomatic minors is prohibited.
- Patients with unstable acute neurological conditions (e.g., status epilepticus within 24 hours) must be clinically stabilized before specimen collection.
- Individuals with a history of bone marrow transplantation may show confounding results due to mixed chimerism.
Seek emergency care if: seizures last longer than 5 minutes, consciousness is not regained between episodes, or breathing difficulties occur.
Patient FAQ & Clinical Guidance
1. What is the LGI1 gene test used for?
This test identifies disease-causing mutations in the LGI1 gene responsible for autosomal dominant familial temporal lobe epilepsy type 1. It provides a definitive molecular diagnosis, distinguishes this subtype from other epilepsy syndromes, and informs family screening and personalized treatment planning.
2. How is the sample collected?
A standard peripheral whole blood draw (3–5 mL in EDTA) is collected by a DHA-licensed phlebotomist during a VIP Mobile Phlebotomy home visit scheduled between 8 AM and 11 PM. The specimen is transported under validated cold-chain conditions to preserve DNA integrity. Alternatively, extracted genomic DNA of sufficient quality may be submitted.
3. How long do results take, and what support is provided?
Test results are delivered within 3–4 weeks from sample receipt. Each report includes a detailed telephonic interpretation by a Consultant Medical Geneticist and a post-test genetic counseling session at no additional cost to clarify clinical implications, inheritance patterns, and family recurrence risks.
4. Can this test detect all types of epilepsy gene mutations?
This test is specific to the LGI1 gene only. For broader epilepsy panel testing covering multiple genes simultaneously, please consult with our genetic counselor about expanded next-generation sequencing panel options available at DNA Labs UAE.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
DNA Labs UAE operates under DHA Facility License Number 1143 and fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) regarding the collection, processing, storage, and transfer of genetic and health data. All clinical information is encrypted and access-restricted to authorized personnel only. Laboratory operations adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring that digital health records and telemedicine components meet stringent security standards. Patient consent for genetic analysis is obtained in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability, which governs informed consent procedures for diagnostic procedures involving genetic testing.
Clinical & Logistical Metadata
| Test Name | LGI1 Gene Sequencing – Familial Temporal Lobe Epilepsy Type 1 |
| Price (AED) | AED 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or extracted genomic DNA |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV analysis |
| ICD-10-CM Code | G40.2 |
| LOINC Code | 81321-3 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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