Test Price
2,800 AED✅ Home Collection Available
WFS1 Gene (Cataract Type 41) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين WFS1 (إعتام عدسة العين من النوع 41) بتقنية NGS في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
DHA ACCREDITED Executive Clinical Summary
يضمن تحليل تسلسل جين WFS1 بتقنية NGS في مختبرنا الحاصل على اعتماد ISO دقة تشخيصية تزيد عن 99.9% وسرية تامة وفقًا للمرسوم بقانون اتحادي رقم 41 لسنة 2024 وقوانين حماية البيانات في الإمارات، مع خدمات سحب منزلي متميزة وإرشاد وراثي بعد الفحص.
- Diagnostic Precision Guarantee: 99.9% analytical sensitivity and specificity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited NGS platform, covering all exons, exon-intron boundaries, and deep intronic regions of the WFS1 gene.
- VIP Logistics: Paid hospital-grade home collection by DHA-licensed phlebotomists (8 AM – 11 PM) with ISO-certified cold-chain transport for sample integrity.
- Clinical Guidance: Complimentary telephonic post-test genetic counselling and clinical result interpretation by a DHA-registered clinical geneticist.
- Insurance & Billing: Direct billing verification and pre-authorization support via WhatsApp +971 54 548 8731.
Clinical Overview
The WFS1 Gene (Cataract Type 41) Genetic Test provides complete sequencing of the wolframin encoding gene to establish a molecular diagnosis for congenital/early-onset cataracts and classic Wolfram syndrome (DIDMOAD). This definitive assay identifies single nucleotide variants, small insertions/deletions, and copy number changes with a rapid 3–4 week turnaround—far exceeding targeted panel approaches in variant detection breadth. يوفر اختبار التسلسل الجيني الكامل لجين WFS1 تشخيصًا جزيئيًا دقيقًا لإعتام عدسة العين من النوع 41 ومتلازمة ولفرام، مع تغطية تحليلية شاملة خلال 3–4 أسابيع فقط.
| Feature | OUR NGS TEST WFS1 Full Gene Sequencing | Conventional Gene Panel / Sanger |
|---|---|---|
| Genomic Coverage | All exons, splice sites (±20 bp), promoter, and deep intronic regions (≥1000× mean depth) | Common hotspots or selected exons only; may miss regulatory/intronic variants |
| Diagnostic Sensitivity | >99.9% for SNVs/indels and CNVs within targeted regions | ~85% for point mutations; limited CNV detection |
| Turnaround Time | 3–4 Weeks (expedited 2-week option available) | 4–8 Weeks |
Clinician’s Perspective & Safety Protocol
Dr. PRABHAKAR REDDY, DHA Licensed Ophthalmologist (License: 61713011): “As an ophthalmologist practicing in the UAE, I’ve seen how a genetic cataract diagnosis can cause anxiety and confusion. This test isn’t just about the lens—it uncovers systemic risks like diabetes and hearing loss in Wolfram syndrome, guiding early intervention. Please remember that a genetic result must always be interpreted alongside a comprehensive eye exam and systemic evaluation; this panel provides a piece of the puzzle, not the entire clinical picture.”
Medication Advisory:
Do not discontinue or adjust any prescribed medication (e.g., insulin, corticosteroid eye drops) without explicit consultation with your treating physician.
⚠️Safety Exclusion Criteria & Emergency Red Flags
- Exclusions: No strict exclusion for genetic blood sampling; however, patients with active bleeding disorders or severe needle phobia should inform the phlebotomist. FTA card collection is an alternative.
- Emergency Red Flags: If you experience sudden vision loss, severe ocular pain, acute hearing decline, or symptoms of diabetic ketoacidosis (extreme thirst, confusion, abdominal pain) do not wait for test results—seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What exactly does the WFS1 genetic test detect, and why is it critical for cataract patients? ما الذي يكشفه اختبار جين WFS1 ولماذا هو بالغ الأهمية لمرضى إعتام عدسة العين؟
Snippet Answer: This test identifies pathogenic and likely pathogenic variants in the WFS1 gene responsible for autosomal recessive cataracts type 41 and Wolfram syndrome, enabling precise genetic counselling and personalized surveillance plans. Beyond cataract surgery timing, a positive result alerts clinicians to screen for diabetes mellitus, optic atrophy, and deafness, drastically improving long-term outcomes. All interpretation follows 2026 DHA molecular pathology guidelines and is accompanied by a verified clinical report.
2. How is the sample collected and do you offer home collection in the UAE? كيف يتم جمع العينة وهل تقدمون خدمة السحب المنزلي في الإمارات؟
Snippet Answer: A hospital-grade DHA-licensed phlebotomist collects 3–5 mL of whole blood (EDTA tube) or a single drop on an FTA card, with home collection available daily 8 AM – 11 PM across all emirates. The specimen is transported in ISO-certified cold-chain to our central lab, eliminating patient travel. Special precautions for pediatric/minor patients comply strictly with UAE CDS Law 2026—a consenting guardian must be present.
3. What preparation is required and is genetic counselling mandatory? ما التحضيرات المطلوبة وهل الإرشاد الوراثي إلزامي؟
Snippet Answer: A mandatory pre-test genetic counselling session (telehealth or in-person) is required to draw a detailed family pedigree and explain inheritance patterns, while no fasting or medication changes are needed for the blood draw itself. This counselling, documented in a signed informed consent, fulfills UAE PDPL data privacy requirements and ensures you understand the implications for at-risk relatives. Results will only be released after a post-test counselling appointment.
This offering is fully compliant with Federal Decree-Law No. 41 of 2024 (Art. 87) on the Regulation of Genetic Testing, the UAE Child Data Safeguard (CDS) Law 2026 for minors, and the UAE Personal Data Protection Law (PDPL). All laboratory procedures maintain ISO 9001:2015 certification (INT/EGQ/2509DA/3139). DHA Facility License: 9834453.
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