Test Price
2,800 AED✅ Home Collection Available
WFS1 Gene (Cataract Type 41) Genetic Test in UAE | 2800 AED | DHA-Accredited
Executive Summary & Core Metrics
DHA ACCREDITED Executive Clinical Summary
- Diagnostic Precision Guarantee: 99.9% analytical sensitivity and specificity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited NGS platform, covering all exons, exon-intron boundaries, and deep intronic regions of the WFS1 gene.
- VIP Logistics: Hospital-grade home collection by DHA-licensed phlebotomists (8 AM – 11 PM) with ISO-certified cold-chain transport for sample integrity.
- Clinical Guidance: Complimentary telephonic post-test genetic counselling and clinical result interpretation by a DHA-registered clinical geneticist.
- Insurance & Billing: Direct billing verification and pre-authorization support via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The WFS1 Gene (Cataract Type 41) Genetic Test provides complete sequencing of the wolframin encoding gene to establish a molecular diagnosis for congenital/early-onset cataracts and classic Wolfram syndrome (DIDMOAD). This definitive assay identifies single nucleotide variants, small insertions/deletions, and copy number changes with a rapid 3–4 week turnaround—far exceeding targeted panel approaches in variant detection breadth.
| Feature | OUR NGS TEST WFS1 Full Gene Sequencing | Conventional Gene Panel / Sanger |
|---|---|---|
| Genomic Coverage | All exons, splice sites (±20 bp), promoter, and deep intronic regions (≥1000× mean depth) | Common hotspots or selected exons only; may miss regulatory/intronic variants |
| Diagnostic Sensitivity | >99.9% for SNVs/indels and CNVs within targeted regions | ~85% for point mutations; limited CNV detection |
| Turnaround Time | 3–4 Weeks (expedited 2-week option available) | 4–8 Weeks |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403: “As a board-certified medical geneticist practicing in the UAE, I emphasize that this comprehensive WFS1 sequencing test extends beyond cataract—it uncovers systemic risks such as diabetes and hearing loss in Wolfram syndrome. The results must be interpreted within a full clinical context including ophthalmic, audiologic, and metabolic assessments. Pre-test counselling is mandatory to ensure patients understand the implications for themselves and their families. This test, combined with expert genetic guidance, empowers proactive surveillance and informed family planning.”
Patient Advisory
Medication Advisory
Do not discontinue or adjust any prescribed medication (e.g., insulin, corticosteroid eye drops) without explicit consultation with your treating physician.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusions: No strict exclusion for genetic blood sampling; however, patients with active bleeding disorders or severe needle phobia should inform the phlebotomist. FTA card collection is an alternative.
- Emergency Red Flags: If you experience sudden vision loss, severe ocular pain, acute hearing decline, or symptoms of diabetic ketoacidosis (extreme thirst, confusion, abdominal pain) do not wait for test results—seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What exactly does the WFS1 genetic test detect, and why is it critical for cataract patients?
Answer: This test identifies pathogenic and likely pathogenic variants in the WFS1 gene responsible for autosomal recessive cataracts type 41 and Wolfram syndrome, enabling precise genetic counselling and personalized surveillance plans. Beyond cataract surgery timing, a positive result alerts clinicians to screen for diabetes mellitus, optic atrophy, and deafness, drastically improving long-term outcomes. All interpretation follows DHA molecular pathology guidelines and is accompanied by a verified clinical report.
2. How is the sample collected and do you offer home collection in the UAE?
Answer: A hospital-grade DHA-licensed phlebotomist collects 3–5 mL of whole blood (EDTA tube) or a single drop on an FTA card, with VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across all emirates. The specimen is transported in ISO-certified cold-chain to our central lab, eliminating patient travel. Special precautions for pediatric/minor patients comply strictly with UAE Federal Law No. 2 of 2019—a consenting guardian must be present.
3. What preparation is required and is genetic counselling mandatory?
Answer: A mandatory pre-test genetic counselling session (telehealth or in-person) is required to draw a detailed family pedigree and explain inheritance patterns, while no fasting or medication changes are needed for the blood draw itself. This counselling, documented in a signed informed consent, fulfills UAE PDPL data privacy requirements (Federal Decree-Law No. 45 of 2021) and ensures you understand the implications for at-risk relatives. Results will only be released after a post-test counselling appointment.
UAE Regulatory & Data Privacy Adherence
This diagnostic service complies fully with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genetic data is encrypted, access-controlled, and processed only with explicit patient consent.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Our IT infrastructure meets required standards for health data security, including secure tele-counselling platforms.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Pre- and post-test counselling and sample collection follow strict medical liability protections, ensuring patient safety and informed consent.
- ISO 9001:2015 Certification (INT/EGQ/2509DA/3139): All laboratory processes are audited for quality management.
Clinical & Logistical Metadata
| Test Name | WFS1 Gene (Cataract Type 41) Genetic Test – Full Gene Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (expedited 2-week option available) |
| Sample Type / Matrix | Whole blood (EDTA tube) or FTA card (dried blood spot) |
| Methodology Used | Next-Generation Sequencing (NGS) – full gene sequencing covering exons, splice sites, and deep intronic regions |
| ICD-10-CM Code | Q12.0 (Congenital cataract) |
| LOINC Code | 21662-0 (WFS1 gene analysis in Blood by NGS) |
| DHA Facility License & Laboratory Address | License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians