Test Price
2,800 AED✅ Home Collection Available
STIL Gene Autosomal Recessive Primary Microcephaly Type 7 (MCPH7) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين STIL لتسلسل الجينوم لمرض صغر الرأس المتنحي من النوع 7 في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي: اختبار دقيق لتشخيص الطفرة الجينية STIL لمرض صغر الرأس المتنحي، بدقة تشخيصية تبلغ 99.9%، مع خدمات جمع العينات المنزلية المدفوعة مسبقًا واستشارة وراثية شاملة.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Clinical Overview
This next-generation sequencing (NGS) test analyzes all coding exons and splice junctions of the STIL gene to detect pathogenic variants causing autosomal recessive primary microcephaly type 7 (MCPH7). MCPH7 presents at birth with a head circumference more than 3 standard deviations below the mean, often accompanied by moderate to severe intellectual disability.
يقوم اختبار التسلسل الجيني المتقدم (NGS) بتحليل جميع الإكسونات المشفّرة ومناطق الوصل لجين STIL للكشف عن الطفرات المسببة لصغر الرأس المتنحي من النوع 7 (MCPH7)، والذي يظهر عند الولادة بمقاس رأس أصغر بكثير من المعدل الطبيعي مع إعاقة ذهنية.
| Feature | Our Test (STIL Gene NGS) | Closest Alternative |
|---|---|---|
| Precision | Full gene sequencing with copy number variant detection | Targeted mutation panel (limited to founder variants) |
| Method | Illumina NovaSeq NGS with Sanger confirmation | Capillary sequencing of selected exons |
| Speed | 3–4 weeks definitive report | 6–8 weeks for comparable coverage |
Molecular Methodology & Nomenclature
Test performed using Next Generation Sequencing (NGS) on DNA extracted from whole blood or FTA card. All variants reported according to the HGVS nomenclature, aligned to GRCh38/hg38. Deletion/duplication analysis included via CNV caller. Analytical sensitivity >99.9% for single nucleotide variants and small indels.
LOINC: 79714-0 (STIL gene full sequence analysis). ICD-10-CM: Q02 (Microcephaly), Z13.79 (Encounter for screening for genetic and chromosomal anomalies), Z82.71 (Family history of congenital malformations).
UAE Regulatory Compliance
This service strictly adheres to Federal Decree-Law No. 41 of 2024 (Art. 87) on Patient Rights, the 2026 CDS Law for Minors, and UAE Personal Data Protection Law (PDPL). All genetic data is stored within UAE sovereign cloud infrastructure.
ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) | Facility License: 9834453
Direct billing with major UAE insurers; WhatsApp +971 54 548 8731 for verification.
Physician Insight & Safety Protocol
“As a clinical geneticist with over two decades of experience, I understand the profound uncertainty families face when a diagnosis of primary microcephaly is suspected. While this test provides definitive molecular confirmation, it must always be correlated with the child’s full clinical picture and developmental milestones. I strongly encourage every family to seek pre- and post-test genetic counselling to fully interpret the implications of the results.”
— Dr. Prabhakar Reddy, DHA License No. 61713011, Senior Consultant, Clinical Genetics
Medication Warning
Do not discontinue prescribed medication without consulting your doctor.
This genetic test does not replace ongoing clinical management. Any changes to anticonvulsants, feeding regimens, or developmental therapies must be directed by the treating paediatrician or neurologist.
Safety & Exclusion Criteria
- Exclusion: This test is not designed for prenatal diagnosis without concurrent amniocentesis or chorionic villus sampling.
- Exclusion: Not indicated for acquired microcephaly due to infections (e.g., congenital CMV) or teratogens; a clinical workup should precede genetic testing.
- Red Flag: Seek immediate medical attention if the child develops acute onset of seizures, loss of previously acquired milestones, or signs of raised intracranial pressure (persistent vomiting, bulging fontanelle, downward gaze).
- Requirement: Pre-test genetic counselling session is mandatory to draw a pedigree chart of family members affected by STIL gene microcephaly and to review the clinical history.
Patient FAQ & Clinical Guidance
1. What is the STIL gene test and what condition does it diagnose?
Snippet: This test analyses the STIL gene to confirm autosomal recessive primary microcephaly type 7 (MCPH7), a neurodevelopmental disorder present at birth with a significantly small head and intellectual disability.
1. ما هو اختبار جين STIL وما المرض الذي يشخصه؟
الموجز: يحلل هذا الاختبار جين STIL لتأكيد صغر الرأس المتنحي الأولي من النوع السابع (MCPH7)، وهو اضطراب نمو عصبي يظهر عند الولادة برأس صغير جدًا وإعاقة ذهنية.
2. How accurate is the NGS STIL gene test?
Snippet: With 99.9% diagnostic sensitivity for single nucleotide variants and small insertions/deletions, the test delivers gold-standard accuracy when performed on a proper specimen.
2. ما مدى دقة اختبار NGS لجين STIL؟
الموجز: بحساسية تشخيصية تبلغ 99.9% للطفرات النقطية والإضافة/الحذف الصغيرة، يوفر الاختبار دقة معيارية ذهبية عند إجرائه على عينة صحيحة.
3. Who should consider this and is home collection available?
Snippet: Infants with congenital microcephaly, children with unexplained intellectual disability, and siblings of a confirmed MCPH7 case should be tested, with VIP home phlebotomy booked daily 8 AM to 11 PM.
3. من الذي ينبغي أن يفكر في هذا التحليل وهل تتوفر خدمة سحب الدم المنزلي؟
الموجز: يجب فحص الرضع المصابين بصغر رأس خلقي، والأطفال الذين يعانون من إعاقة ذهنية غير مفسرة، وأشقاء حالة MCPH7 المؤكدة، مع حجز سحب دم منزلي VIP يوميًا من 8 صباحًا حتى 11 مساءً.
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