Test Price
2,800 AEDโ Home Collection Available
SMAD6 Gene Aortic Valve Disease Type 2 โ Genetic Test in UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain & VIP Mobile Phlebotomy (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test analyzes the entire coding region of the SMAD6 gene for pathogenic variants linked to aortic valve disease type 2 and thoracic aortic aneurysms. It is recommended for individuals with a family history of bicuspid aortic valve, early aortic dissection, or related aortopathies.
| Feature | Our SMAD6 NGS Test | Standard Sanger Sequencing |
|---|---|---|
| Technology | High-depth Next-Generation Sequencing (NGS) | Chain-termination (Sanger) sequencing |
| Variant Detection | Full gene coverage: all exons, splice sites & indels | Limited to targeted regions or known mutations |
| Turnaround Time | 3 โ 4 Weeks | 6 โ 8 Weeks |
| Analytical Sensitivity | >99.9% | ~95% |
| Cost (UAE) | AED 2800 | AED 1500 โ 2000 |
Physician Insight & Safety Protocols
โA pathogenic SMAD6 variant indicates a significantly elevated lifetime risk for aortic valve disease and thoracic aortic aneurysm. However, this genetic result must always be interpreted alongside cardiac imaging (echocardiogram, MRI) and a detailed family history. A positive test does not mandate immediate intervention but does require vigilant surveillance. Genetic counselling is an integral part of this process.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
Warning:
Do not discontinue any prescribed medication (e.g., beta-blockers, antihypertensives) based solely on genetic test results. Always consult your treating physician before making changes to your medication regimen.
Exclusion Criteria & Emergency Red Flags
- Not suitable for patients with severe bleeding disorders or inability to provide a blood/DNA sample.
- Minors (<18 years) require parental consent and mandatory genetic counselling as per UAE Federal Decree-Law No. 4 of 2016 on Medical Liability.
- If you experience sudden chest pain, severe shortness of breath, fainting, or palpitations, seek immediate emergency careโdo not wait for genetic results.
Patient FAQ & Clinical Guidance
1. What does a positive SMAD6 gene result mean for my heart health?
Snippet: A positive SMAD6 finding confirms a genetic predisposition to aortic valve disease and thoracic aortic aneurysm, but does not guarantee disease manifestation. Clinical follow-up with regular echocardiograms and vascular assessments is essential to monitor aortic dimensions and valve function.
2. How accurate is this NGS test and what is the turnaround time?
Snippet: High-depth Next-Generation Sequencing ensures >99% analytical sensitivity and comprehensive exon coverage of SMAD6, delivering results in 3-4 weeks for informed decision-making. The test uses clinically validated protocols and ISO-certified data analysis pipelines.
3. Do I need genetic counselling before the test?
Snippet: Pre-test genetic counselling is mandatory under UAE Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring you fully understand implications before proceeding. Our package includes a session with a board-certified genetic counsellor who will draw a detailed family pedigree and explain inheritance patterns.
UAE Regulatory & Data Privacy Adherence
Your genetic data is handled in strict compliance with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing, safety, and patient consent procedures are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE is fully committed to maintaining the highest standards of data security and patient confidentiality.
Clinical & Logistical Metadata
| Test Name | SMAD6 Gene Aortic Valve Disease Type 2 โ Genetic Test |
| Price (AED) | AED 2,800 |
| Turnaround Time | 3 โ 4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available Daily 8 AM โ 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage |
| ICD-10-CM Code | I35.9 (Nonrheumatic aortic valve disorder, unspecified) |
| LOINC Code | 21636-6 (Sequencing of gene SMAD6) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 โ Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ Corporate Lab: DNA Labs UAE |
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