Test Price
2,800 AEDโ Home Collection Available
POLG Gene MNGIE Without Leukoencephalopathy Genetic Test in UAE
Executive Summary & Core Metrics
Test Name
POLG Gene Sequencing for Mitochondrial Neurogastrointestinal Encephalopathy (MNGIE) Without Leukoencephalopathy
Price
2,800 AED
Turnaround Time
3โ4 Weeks
Sample Type
Peripheral Whole Blood โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available Daily (8 AM โ 11 PM)
Methodology
Next-Generation Sequencing (NGS) โ Full Gene Coverage with >99.9% Analytical Sensitivity
Clinical Guidance
Telephonic Post-Test Clinical Guidance for result interpretation and next steps
Insurance
Direct Billing Verification via WhatsApp at +971 54 548 8731
Accuracy Guarantee
99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Next-Generation Sequencing
Test Overview & Methodology
This advanced genetic test examines the entire POLG gene using Next-Generation Sequencing (NGS) to detect pathogenic variants responsible for Mitochondrial Neurogastrointestinal Encephalopathy (MNGIE) without leukoencephalopathy. It supports definitive diagnosis, carrier screening, and familial risk assessment. The POLG gene encodes the catalytic subunit of mitochondrial DNA polymerase gamma, essential for mitochondrial DNA replication and repair. Pathogenic variants in POLG are a common cause of mitochondrial disorders, and this test provides comprehensive coverage of all coding exons, intronic flanking regions, and known deep intronic variants.
| Parameter | Our Test | Closest Alternative |
|---|---|---|
| Precision | Full gene NGS with >99.9% analytical sensitivity and copy number variant detection | Sanger sequencing of selected exons, may miss deep intronic or structural variants |
| Method | Next-Generation Sequencing (NGS) โ full gene sequencing | Limited gene panel or single-site testing with lower sensitivity |
| Turnaround Time | 3โ4 Weeks | 6โ8 Weeks (typical for send-out reference laboratories) |
Physician Insight & Safety Protocols
Dr. Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403) notes: "Comprehensive POLG gene sequencing provides definitive molecular confirmation for MNGIE without leukoencephalopathy, enabling targeted clinical management and evidence-based family planning. A negative result does not exclude other mitochondrial encephalopathies; clinical correlation with neurological, gastrointestinal, and metabolic findings remains essential. All positive findings must be interpreted within a formal genetic counseling framework before any therapeutic or reproductive decisions are made."
Advisory: Medication Continuation
Do not discontinue, adjust, or initiate any prescribed medication, including mitochondrial supplements or anticonvulsants, without consulting your treating physician. Abrupt medication changes in the context of mitochondrial dysfunction may precipitate acute metabolic decompensation or neurological deterioration.
Exclusion Criteria & Emergency Red Flags
- Unstable neurological status requiring emergency hospitalization or intensive care support.
- Inability to provide informed consent or attend mandatory pre-test genetic counseling.
- Hemolyzed blood, insufficient DNA yield, or improper specimen storage compromising sequencing quality.
- If you develop acute worsening of neurological symptoms (seizures, stroke-like episodes, severe gastrointestinal obstruction, or metabolic acidosis), seek immediate emergency careโdo not wait for test results.
Patient FAQ & Clinical Guidance
1. What does a positive POLG gene test mean for my health?
A positive result confirms a pathogenic or likely pathogenic variant in the POLG gene, establishing the diagnosis of MNGIE without leukoencephalopathy. This enables targeted clinical management including mitochondrial supplementation, gastrointestinal motility support, and regular neurological surveillance. It also allows for informed family planning and predictive testing for at-risk relatives following genetic counseling.
2. Can this test be performed on children?
Yes, with mandatory parental or guardian consent and compulsory pre-test genetic counseling, as required by UAE Federal Decree-Law No. 4 of 2016 on Medical Liability for predictive genetic testing in minors. This ensures ethical handling of genetic information and appropriate psychological support for families.
3. How long until I receive results and are they confidential?
Results are delivered within 3โ4 weeks from sample receipt. All genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and stored on encrypted servers accessible only to you and your authorized physician. Results are never shared with third parties without explicit written consent.
4. What is the difference between MNGIE with and without leukoencephalopathy?
MNGIE typically presents with leukoencephalopathy (white matter changes visible on brain MRI), but a subset of patients harbor POLG variants that cause the syndrome without significant white matter involvement. This test specifically detects variants associated with the non-leukoencephalopathy phenotype, which may present with more prominent gastrointestinal and peripheral neurological symptoms while preserving normal brain imaging. Accurate genotyping guides prognosis and management strategy.
UAE Regulatory & Data Privacy Adherence
This service operates in full compliance with UAE federal data protection and healthcare regulations. All patient genetic data is processed and stored under the provisions of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and operates under DHA and MOHAP regulatory standards. Patient data sovereignty and confidentiality are guaranteed at all stages of the diagnostic pathway.
DNA Labs UAE is a licensed DHA facility (License No. 1143) committed to the highest standards of genetic testing quality, privacy, and ethical practice.
Clinical & Logistical Metadata
| Test Name | POLG Gene Sequencing โ MNGIE Without Leukoencephalopathy |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood โ VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily 8 AM โ 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Sequencing |
| ICD-10-CM Code | E88.8 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians