Test Price
2,800 AED✅ Home Collection Available
POGZ Gene Sequencing (Mental Retardation, Autosomal Dominant Type 37) Test in UAE | 2,800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection by DHA-Licensed Phlebotomists (8 AM–11 PM).
Clinical Guidance: Complimentary Post-Test Telephonic Clinical Interpretation by a Senior Genetic Counselor.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 (within 1 hour).
Test Overview & Methodology
The POGZ gene sequencing test detects pathogenic variants causing autosomal dominant mental retardation type 37 (MRD37), a neurodevelopmental disorder marked by intellectual disability, speech delay, and behavioral abnormalities. The analysis uses targeted next-generation sequencing (NGS) with 150x mean depth and Sanger confirmation to deliver definitive diagnostic accuracy.
| Feature | Our Test (POGZ Gene Sequencing) | Closest Alternative (Whole Exome Trio) |
|---|---|---|
| Methodology | Targeted NGS with 150x mean depth & Sanger confirmation | Whole Exome Sequencing (average 100x), may miss deep intronic regions |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Clinical Scope | Definitive MRD37 diagnosis, parental variant testing | Broad screen, incidental findings and VUS may delay diagnosis |
| Price | 2,800 AED | 4,500 – 6,000 AED |
| UAE Regulatory Status | DHA/MOHAP Licensed, ISO 9001:2015 | Varies by provider |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh — Consultant Medical Genetics (DHA Registration ID: 9294403)
“Clinical genetics moves beyond a laboratory result. A finding of a POGZ variant must be contextualized with the child’s developmental history, family pedigree, and neurological assessments. This test can provide clarity and guide early intervention strategies, but it should never replace a comprehensive clinical evaluation. Always review results with your treating physician before implementing any therapeutic changes.”
Medication Advisory
Important: Do not alter or stop any currently prescribed medications—including anticonvulsants, antipsychotics, or stimulants—without consulting your healthcare provider. A genetic test result does not offer immediate therapeutic direction and must be integrated into your overall care strategy by your clinician.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Recent blood transfusion (within 4 weeks) may compromise DNA integrity; reschedule appointment accordingly.
- Exclusion: Patients on high‑dose anticoagulants (e.g., warfarin, enoxaparin) require alternative collection via FTA card to minimize hematoma risk.
- ER Red Flag: If the patient experiences acute suicidal ideation, uncontrolled seizures, or psychotic episodes, proceed immediately to the nearest emergency department—genetic testing does not address urgent safety concerns.
Patient FAQ & Clinical Guidance
1. What is the POGZ gene and how does it cause mental retardation?
The POGZ gene encodes a zinc finger protein essential for chromatin remodeling and neuronal development. Pathogenic variants lead to autosomal dominant intellectual disability type 37 (MRD37), characterized by global developmental delay, speech impairment, and distinctive facial features. Genetic testing identifies the specific mutation to confirm the diagnosis.
2. How is the test performed and what sample is needed?
A certified phlebotomist collects a whole blood sample (or a single drop on an FTA card) during a home visit between 8 AM and 11 PM. DNA is then extracted and sequenced using high‑coverage NGS to detect POGZ mutations with 99.9% sensitivity. The process is handled under ISO‑certified cold‑chain logistics.
3. What do the results mean for my child’s future management?
A definitive genetic diagnosis clarifies prognosis, guides speech/occupational/behavioral therapies, enables informed family planning, and may open access to clinical trials. A board‑certified genetic counselor will explain the implications and next steps in a dedicated post‑test session.
UAE Regulatory & Data Privacy Adherence
Data Protection: All genetic and personal data are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient information remains encrypted and stored on UAE‑sovereign cloud servers.
Clinical Consent: Genetic testing is conducted under the clinical safety framework of Federal Decree-Law No. 4 of 2016 on Medical Liability. Written informed consent is obtained prior to sample collection, and results are released only to the ordering physician.
Clinical & Logistical Metadata
| Attribute | Details |
|---|---|
| Test Name | POGZ Gene Sequencing (Mental Retardation, Autosomal Dominant Type 37) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (3-5 mL in EDTA tube) or FTA Card |
| Methodology Used | Targeted NGS with Sanger confirmation |
| ICD-10-CM Code | F79 |
| LOINC Code | 94896-4 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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