Test Price
2,800 AEDโ Home Collection Available
PLCE1 Gene (Nephrotic Syndrome Type 3) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
99.9% clinical sensitivity via ISO-accredited Next-Generation Sequencing for comprehensive PLCE1 variant detection.
VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection. Available daily from 8 AM to 11 PM.
Telephonic clinical consultation for result interpretation, carrier risk assessment, and family planning decisions.
Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced molecular analysis employs Next-Generation Sequencing (NGS) to examine the PLCE1 gene for pathogenic variants associated with autosomal recessive nephrotic syndrome type 3. The test provides definitive molecular diagnosis, determines carrier status, and supports informed reproductive planning. Conducted under DHA-approved protocols with integrated pre-test and post-test genetic counselling.
| Feature | NGS Platform (DNA Labs UAE) | Conventional Sanger Sequencing |
|---|---|---|
| Analytical Sensitivity | 99.9% with full gene coverage including intronic regions | 95โ98% exon-by-exon with limited intronic detection |
| Methodology | NGS with MLPA backup for copy-number variant confirmation | Single-exon Sanger sequencing, lower throughput |
| Turnaround Time | 3โ4 Weeks | 4โ5 Weeks |
Physician Insight & Safety Protocols
โThe PLCE1 gene encodes phospholipase C epsilon-1, a critical signalling protein in podocyte architecture. Pathogenic variants lead to disintegration of the glomerular filtration barrier, manifesting as early-onset steroid-resistant nephrotic syndrome. NGS-based analysis delivers definitive molecular classification, enabling targeted therapeutic strategies and accurate recurrence risk counselling for affected families.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
โ ๏ธ Medication Advisory
Do not alter, pause, or discontinue any prescribed nephroprotective or immunosuppressive therapy without explicit consultation with your managing nephrologist.
๐จ Patient Safety: Exclusion Criteria & Emergency Indicators
- Exclusion Criteria: Individuals under 18 years of age without verified guardian consent per UAE paediatric genetic testing regulations; inability or unwillingness to provide a documented three-generation pedigree; contraindication to peripheral venipuncture.
- Emergency Red Flags: Rapidly progressing anasarca (generalized body oedema), oliguria with urine output below 0.5 mL/kg/hour, new-onset severe hypertension, or altered level of consciousness.
If any of these emergency signs are present, seek immediate acute medical care. This genetic test does not replace emergency evaluation or acute symptomatic management.
Patient FAQ & Clinical Guidance
1. What is the PLCE1 gene test used for?
This test identifies disease-causing mutations in the PLCE1 gene to confirm a diagnosis of nephrotic syndrome type 3, determine carrier status, and guide reproductive decisions.
2. How is the sample collected and processed?
A standard peripheral blood draw is performed. DNA is extracted, and NGS sequencing reads the entire PLCE1 gene with deep coverage to detect single-nucleotide variants and small indels with greater than 99% accuracy.
3. What is the turnaround time and total cost?
The test fee is 2800 AED. Results are delivered within 3โ4 weeks, and the price includes a comprehensive molecular report and one genetic counselling session.
UAE Regulatory & Data Privacy Adherence
All genetic data is processed under the protections of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License No. 1143. Genetic counselling is provided in compliance with UAE Ministry of Health guidelines for heritable disease testing.
Clinical & Logistical Metadata
| Test Name | PLCE1 Gene (Nephrotic Syndrome Type 3) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) with MLPA |
| ICD-10-CM Code | N04.9 |
| LOINC Code | 81269-6 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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