Test Price
2,800 AED✅ Home Collection Available
NR5A1 Gene (SPGF8) Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing – Results in 3 to 4 Weeks
- Accuracy Guarantee: 99.9% analytical sensitivity for all coding exons through ISO 9001:2015 accredited next‑generation sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection available daily from 8 AM to 11 PM across all Emirates.
- Clinical Guidance: Post‑test telephonic result interpretation provided by a DHA‑licensed Consultant Medical Genetics specialist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731 – instant pre‑approval for most major UAE networks.
Test Overview & Methodology
The NR5A1 Gene (SPGF8) Genetic Test delivers comprehensive analysis of the nuclear receptor subfamily 5 group A member 1 gene, a master regulator of gonadal development and steroidogenesis. This high‑coverage next‑generation sequencing assay detects single nucleotide variants, small insertions and deletions, and copy number changes with 99.9% diagnostic sensitivity. The test is essential for diagnosing spermatogenic failure type 8, 46,XY disorders of sex development, and related reproductive conditions.
Methodology combines next‑generation sequencing of all coding exons plus flanking intronic regions with orthogonal Sanger confirmation of all clinically actionable variants. Bioinformatic analysis employs validated pipelines aligned to GRCh38/hg38 reference genome, with variant interpretation per ACMG/AMP standards.
| Feature | Our NR5A1 NGS Test | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Precision | 99.9% analytical sensitivity for all coding exons | Limited to single‑amplicon analysis; may miss large deletions |
| Methodology | Next‑Generation Sequencing (NGS) + Sanger confirmation | Sanger sequencing of select exons only |
| Turnaround Time | 3–4 weeks | 4–6 weeks (batch‑dependent) |
Physician Insight & Safety Protocols
"Genetic evaluation of NR5A1 provides definitive molecular information for patients presenting with non‑obstructive azoospermia or disorders of sex development. Results must be interpreted within the full endocrine, hormonal, and clinical context. I strongly recommend pre‑test genetic counseling to ensure families have realistic expectations and understand the implications for reproductive planning."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory Notice
Do not discontinue any prescribed endocrine or fertility medication without consulting your treating physician. This genetic test is a diagnostic tool and does not replace ongoing medical management or therapy.
Exclusion Criteria & Emergency Red Flags
- Test not performed on minors without both parental/guardian consent and a court‑appointed guardian where required under UAE child data protection regulations.
- Patients with active severe infection or haemodynamic instability – address acute condition before sample collection.
- Inadequate blood or FTA card sample volume; lipemic or haemolysed specimens may be rejected for processing.
- Red Flag: If the individual experiences acute adrenal crisis symptoms (vomiting, severe hypotension, altered consciousness) before or after testing, seek immediate emergency care. This test is not a substitute for urgent medical evaluation.
Patient FAQ & Clinical Guidance
1. What does the NR5A1 gene test detect?
Snippet: This high‑precision NGS assay detects all clinically significant variants in the NR5A1 gene, including point mutations, splice‑site alterations, and exon‑level deletions linked to male infertility and disorders of sex development.
2. Who should consider this test?
Snippet: Men with non‑obstructive azoospermia, individuals with 46,XY disorder of sex development, women with premature ovarian failure, or anyone with a family history of NR5A1‑related reproductive conditions should consider this comprehensive genetic analysis.
3. How is the sample collected and what preparation is required?
Snippet: A routine venipuncture blood draw or a single drop of blood on a Whatman FTA card is collected via our temperature‑controlled cold‑chain home service. Mandatory pre‑test genetic counseling and completion of a detailed family health pedigree are required before scheduling collection.
4. How long does it take to get results?
Snippet: The standard turnaround time is 3 to 4 weeks from sample receipt in the laboratory. This includes NGS library preparation, sequencing, bioinformatic analysis, variant confirmation, and clinical report generation.
5. Will insurance cover the test cost?
Snippet: Coverage varies by insurance provider and policy. Direct billing verification can be initiated via WhatsApp at +971 54 548 8731 to confirm pre‑approval status before scheduling your sample collection.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) governing the processing of genetic and health data. All genomic data are encrypted, access‑controlled, and stored within UAE‑based secure servers. Our laboratory also adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields for electronic health record integrity and telemedicine practice. Patient consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability to ensure informed consent, confidentiality, and the right to withdraw at any stage of testing.
Clinical & Logistical Metadata
| Test Name | NR5A1 Gene (SPGF8) Genetic Test – Next‑Generation Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Whatman FTA Card – VIP Mobile Phlebotomy & Temperature‑Controlled Cold‑Chain Home Collection enabled |
| Methodology Used | Next‑Generation Sequencing (NGS) with Sanger confirmation of all clinically actionable variants |
| ICD-10-CM Code | N46.0, N46.9 |
| LOINC Code | 90372-6 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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