Test Price
2,800 AED✅ Home Collection Available
MVK Gene Mevalonic Aciduria Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity – ISO-accredited NGS testing with complete gene coverage.
- Premium Logistics – VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection available daily from 8 AM to 11 PM.
- Clinical Guidance – Complimentary post‑test telephonic clinical guidance for result interpretation by our genetic counsellors.
- Insurance Direct Billing – Verify via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The MVK gene mevalonic aciduria NGS test analyzes the entire coding region of the MVK gene to identify pathogenic variants responsible for mevalonate kinase deficiency, a rare autosomal recessive metabolic disorder. This definitive genetic test replaces less specific biochemical assays and guides personalized management, including enzymatic trigger avoidance and anti‑inflammatory therapy.
| Feature | Our MVK NGS Test | Biochemical Mevalonic Acid Urine Assay |
|---|---|---|
| Precision | 99.9% sensitivity for all pathogenic SNVs, indels, CNVs | ~85% diagnostic sensitivity; cannot detect all variants |
| Method | Next‑Generation Sequencing (NGS) + Bioinformatic Confirmation | Gas Chromatography‑Mass Spectrometry (GC‑MS) |
| Turnaround Time | 3–4 Weeks (definitive molecular report) | 5–10 Days (may require genetic confirmation) |
Physician Insight & Safety Protocols
“Genetic testing for mevalonic aciduria provides a definitive diagnosis, enabling tailored management and family counseling. Our NGS approach offers high accuracy, but results must be interpreted in the context of clinical presentation and family history.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue any prescribed medication without consulting your doctor. Genetic test results may influence drug choices but must be evaluated in the context of your full clinical picture.
Patient Safety & Exclusion Criteria
Exclusion Criteria
- Active bleeding or inability to provide blood sample.
- Recent whole blood transfusion within 4 weeks (prefer extracted DNA or FTA card).
- Known interfering condition that prevents accurate NGS interpretation (physician’s judgment).
Emergency Red Flags (Seek Immediate Medical Attention)
- Severe metabolic crisis: vomiting, altered consciousness, tachypnoea.
- Unexplained seizures or coma.
- Acute signs of hyperinflammation (high fever, organomegaly).
Compliance: Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL), Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, and Federal Decree‑Law No. 4 of 2016 on Medical Liability. Our Dubai facility license DHA 1143.
Patient FAQ & Clinical Guidance
1. What is the MVK Gene Mevalonic Aciduria NGS Test and why is it done?
This test sequences the entire MVK gene to detect mutations causing mevalonic aciduria, a rare metabolic disorder, providing a definitive diagnosis. It is performed when clinical symptoms (recurrent fevers, developmental delay, dysmorphic features) suggest mevalonate kinase deficiency, or for carrier screening in families with known mutations. The NGS approach identifies single nucleotide variants, insertions/deletions, and copy number variations with >99% accuracy.
2. What sample types are accepted and how is the collection done?
We accept whole blood, extracted DNA, or one drop of blood on an FTA card. Home collection is available via our VIP mobile phlebotomy service between 8 AM and 11 PM, with temperature‑controlled cold‑chain transport to the ISO‑accredited laboratory. FTA cards are ideal for remote areas or pediatric patients, preserving DNA integrity without immediate refrigeration.
3. When will I receive results and how are they interpreted?
A comprehensive report is delivered within 3 to 4 weeks, including variant classification and actionable clinical guidance. Results are interpreted by our genetic specialists using current ACMG guidelines, categorizing variants as pathogenic, likely pathogenic, or of uncertain significance. A complimentary post‑test consultation is provided to discuss implications for treatment, family planning, and follow‑up.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License 1143. All genetic data is processed in strict compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient safety and informed consent adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. The laboratory maintains ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | MVK Gene Mevalonic Aciduria NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood, extracted DNA, or FTA card (dried blood spot) |
| Methodology Used | Next‑Generation Sequencing (NGS) with bioinformatic confirmation |
| ICD-10-CM Code | E71.1 |
| LOINC Code | 81278-8 |
| DHA Facility License & Laboratory Address | DHA License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians