Test Price
2,600 AED✅ Home Collection Available
Megalencephalic Leukoencephalopathy with Subcortical Cysts (MLC) Gene Sequencing in UAE | AED 2,600
Executive Summary & Core Metrics
✔ Diagnostic Accuracy: 99.9% sensitivity with ISO 9001:2015 certified processing (Cert: INT/EGQ/2509DA/3139).
✔ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
✔ Clinical Guidance: Complimentary telephonic post-test consultation to interpret your results.
✔ Insurance Support: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test with Sanger confirmation analyzes the MLC1 and GLIALCAM genes to diagnose megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare autosomal recessive leukodystrophy. The test provides definitive molecular characterization for patients presenting with macrocephaly and neurological decline, enabling accurate prognosis and recurrence risk assessment.
| Feature | Our Test (ISO-Accredited Lab) | Standard Genetic Panel |
|---|---|---|
| Precision | NGS + Sanger validation for variants | NGS only; variants may need confirmation |
| Method | Targeted MLC gene sequencing (MLC1, GLIALCAM) | Broader leukodystrophy panel, may miss rare variants |
| Turnaround Time | 40 working days (ISO-accredited) | 60–90 days (variable) |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I understand the uncertainty families face when a child presents with macrocephaly and early neurological symptoms. This targeted gene sequencing for MLC1 and GLIALCAM provides a definitive molecular diagnosis that directly informs prognosis, recurrence risk counseling, and long-term management planning. Results must always be correlated with clinical and imaging findings by a qualified clinical geneticist.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Advisory on Medication Continuity
⚠ Medication Warning
Do not discontinue any antiepileptic, neurological, or prescribed medication without direct consultation with your treating physician. Genetic test results are diagnostic tools and do not replace clinical management or alter existing treatment regimens without professional oversight.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Sample not collected in Lavender Top (EDTA) tubes, insufficient volume (<5 mL), or frozen specimen.
- Exclusion: Missing or incorrectly filled Whole Exome Sequencing Consent Form (Form 37) is mandatory.
- ER Red Flag: Seek immediate emergency care if patient develops acute vision loss, uncontrolled seizure activity, or sudden decline in consciousness.
Patient FAQ & Clinical Guidance
1. How accurate is this gene sequencing test for diagnosing MLC in children with macrocephaly?
Our NGS platform with Sanger confirmation achieves greater than 99.9% diagnostic sensitivity for pathogenic variants in MLC1 and GLIALCAM, providing a definitive molecular diagnosis when clinical suspicion is elevated. Correlation by a board-certified clinical geneticist or neurologist is required to confirm the full disease phenotype.
2. What is the turnaround time for MLC gene sequencing results?
The standard turnaround time is 40 working days from sample receipt in the laboratory, reflecting the rigorous ISO-accredited processes including NGS library preparation, sequencing, bioinformatics analysis, and Sanger confirmation of all clinically significant variants.
3. Can insurance cover this test and is home sample collection available?
Direct billing to major UAE insurers is available; send your policy details via WhatsApp to +971 54 548 8731 for verification. Home sample collection is offered daily from 8 AM to 11 PM using VIP Mobile Phlebotomy with temperature-controlled cold-chain transport to preserve specimen integrity.
UAE Regulatory & Data Privacy Adherence
All services at DNA Labs UAE operate in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — governing the lawful collection, processing, and storage of patient genomic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — ensuring secure electronic health data exchange.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — establishing the standard of care for sample collection, genetic counseling, and clinical safety.
DNA Labs UAE is a DHA-licensed facility (License No. 1143) subject to regular audit by the Dubai Health Authority and the Ministry of Health and Prevention.
Clinical & Logistical Metadata
| Test Name | Megalencephalic Leukoencephalopathy with Subcortical Cysts (MLC) Gene Sequencing |
| Price (AED) | AED 2,600 |
| Turnaround Time | 40 working days |
| Sample Type / Matrix | Whole blood (10 mL, min. 5 mL) in two Lavender Top EDTA tubes, shipped refrigerated. Do not freeze. Whole Exome Sequencing Consent Form (Form 37) mandatory. |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | G93.49, E75.29, Z15.89 |
| LOINC Code | 81247-7 |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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