Test Price
2,800 AED✅ Home Collection Available
LCAT Gene Fish-Eye Disease Genetic Test in Dubai | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 15189-accredited NGS workflow with independent variant confirmation.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test clinical interpretation by Consultant Medical Genetics Lina Osama Zaki Quteineh, included at no extra cost.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Compliance & Data Privacy: This test strictly follows Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic data is stored and processed exclusively within the UAE under ISO 9001:2015 quality management.
Who Should Order This Test?
Three high-relevance specialists drive the clinical decision to request LCAT gene sequencing:
- Ophthalmologists – investigate hereditary corneal opacities (fish-eye disease) and differentiate LCAT deficiency from other stromal dystrophies.
- General Physicians – screen for metabolic aetiologies in patients with extremely low HDL-cholesterol and arcus cornealis, guiding early cardiovascular risk management.
- Medical & PhD Researchers – require high-fidelity genomic data to characterize novel LCAT variants, study HDL metabolism, and develop targeted therapies.
Test Overview & Methodology
The LCAT Gene Fish-Eye Disease NGS Test uses next-generation sequencing to capture all coding regions and splice sites of the LCAT gene, identifying pathogenic variants that cause lecithin-cholesterol acyltransferase deficiency. This molecular diagnosis is the definitive tool to confirm fish-eye disease, differentiate it from other corneal dystrophies, and guide family planning.
| Feature | Our Test (LCAT NGS DNA) | Closest Alternative (Enzyme Activity) |
|---|---|---|
| Precision | 99.9% detection of pathogenic SNVs, indels and copy-number variants | May miss heterozygous carriers; normal activity does not exclude all mutations |
| Method | Next-Generation Sequencing (NGS) with Sanger confirmation | Fluorometric enzyme assay on plasma |
| Turnaround | 3–4 Weeks (report with variant interpretation) | 5–7 working days |
| Price (AED) | 2800 | ~1500–2200 |
Physician Insight & Safety Protocols
From Consultant Medical Genetics Lina Osama Zaki Quteineh (DHA License No. 9294403):
“Understanding the genetic basis of corneal opacification is pivotal for accurate diagnosis and family counseling. This NGS assay provides definitive molecular confirmation of LCAT deficiency; however, results must be correlated with a thorough ophthalmic examination and lipid profile. Patients presenting with sudden visual deterioration or acute cardiovascular symptoms should seek emergency care without delay, as genetic findings do not replace immediate clinical intervention.”
Advisory Notice:
Do not discontinue or alter any prescribed medications including lipid-lowering agents or ocular therapies without explicit consultation with your treating physician. The results of this genetic test are intended to support clinical decision-making and should never independently override ongoing therapeutic regimens.
Safety Exclusion & Urgent Red Flags
Exclusion Criteria:
- Individuals under 18 years old without legally authorized guardian consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Inability to provide a venous blood sample or adequate FTA card specimen due to severe needle phobia or coagulopathy.
- Acute febrile illness or systemic infection that may interfere with DNA extraction quality requiring rescheduling.
Proceed to Emergency Room if:
- Sudden, painless vision loss or severe eye pain.
- New onset chest pressure, radiating arm/jaw pain, or shortness of breath.
- Transient ischemic attack symptoms including slurred speech, facial droop, or unilateral weakness.
Patient FAQ & Clinical Guidance
1. What is the LCAT gene and how does it cause Fish-Eye Disease?
The LCAT gene provides instructions for an enzyme that esterifies cholesterol in the bloodstream. Pathogenic mutations result in lecithin-cholesterol acyltransferase deficiency, leading to progressive corneal opacification (fish-eye disease) alongside extremely low high-density lipoprotein (HDL) cholesterol levels. Genetic confirmation is essential to distinguish this condition from other hereditary corneal dystrophies and to guide cardiovascular risk stratification.
2. How is the sample collected and is home service available?
A certified DHA-approved phlebotomist visits your residence between 8 AM and 11 PM to collect one venous blood sample or a capillary drop onto an FTA card. The specimen is transported in a temperature-controlled cold-chain packaging system at no additional cost. This VIP Mobile Phlebotomy service ensures maximum convenience and sample integrity for genetic analysis.
3. When will I receive my results and what happens next?
Test results are available within three to four weeks from sample receipt. The comprehensive report includes variant classification per ACMG guidelines and a detailed clinical interpretation. Consultant Medical Genetics Lina Osama Zaki Quteineh will contact you by telephone to explain the findings, address any questions, and recommend appropriate follow-up including specialist referral or family cascade screening if indicated.
4. What happens if my result is positive for a pathogenic LCAT mutation?
A positive result confirms the diagnosis of fish-eye disease or LCAT deficiency. Your medical genetics consultant will provide a detailed discussion of the implications including corneal management strategies with ophthalmology, cardiovascular risk assessment, and reproductive counseling for family planning. First-degree relatives may be offered targeted testing to determine their carrier status.
UAE Regulatory & Data Privacy Adherence
This genetic test operates in full compliance with the UAE’s stringent data protection and healthcare privacy regulations. All genetic data is processed under the framework of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring that your genomic information remains confidential, encrypted, and stored exclusively within UAE jurisdiction. Clinical safety and informed consent procedures adhere strictly to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | LCAT Gene Fish-Eye Disease Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or FTA card capillary blood |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | H18.2, E78.6 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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