Test Price
2,800 AEDโ Home Collection Available
KRT5 Gene Epidermolysis Bullosa Simplex Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Daily 8 AM โ 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The KRT5 gene NGS test screens for pathogenic variants in the KRT5 gene causing Epidermolysis Bullosa Simplex (EBS), a hereditary disorder characterized by mechanical fragility and blistering of the skin following minor trauma. Using Next-Generation Sequencing, this assay covers the entire coding region and splice junctions, enabling precise molecular diagnosis crucial for prognosis, genetic counselling, and targeted management strategies.
| Feature | Our Test (KRT5 NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next-Generation Sequencing (full gene coverage) | Targeted Sanger (known hotspots only) |
| Diagnostic Sensitivity | >99.9% (including deep intronic variants) | ~70% (may miss novel or deep intronic mutations) |
| Turnaround Time | 3 โ 4 Weeks | 4 โ 6 Weeks |
| Sample Type | Whole Blood, Extracted DNA, or Dried Blood Spot (FTA Card) | Whole Blood only |
| UAE Compliance | ISO 9001:2015, DHA/MOHAP Standards | Variable |
Physician Insight & Safety Protocols
โMolecular diagnosis for Epidermolysis Bullosa Simplex, while highly precise, must always be correlated with clinical presentation, detailed family pedigree, and immunofluorescence mapping when indicated. A negative NGS result on the KRT5 gene does not exclude other subtypes of EB or novel genetic mechanisms. I encourage patients and families to engage with a certified genetic counsellor before and after testing. This test is performed only after obtaining informed consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Management
Medication Warning
Do not discontinue any prescribed treatment without explicit consultation with your dermatologist or attending physician. Abrupt cessation of anti-inflammatory or immunosuppressive therapies can trigger disease flare-ups.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active severe anemia (Hb < 8 g/dL), ongoing anticoagulant therapy that cannot be temporarily held (consult your physician), inability to provide informed consent, intercurrent febrile illness.
- Emergency Red Flags: If you experience sudden, widespread blistering with fever, shortness of breath, difficulty swallowing, or signs of secondary skin infection (pus, increased pain, red streaks), seek immediate emergency care. These symptoms require urgent clinical evaluation.
Patient FAQ & Clinical Guidance
1. What is the KRT5 gene test, and why is it performed?
This NGS test identifies KRT5 mutations causing Epidermolysis Bullosa Simplex, a genetic skin blistering disorder. It clarifies the diagnosis, inheritance pattern, and guides family planning decisions.
2. How is the sample collected and what is the turnaround time?
A certified phlebotomist collects a small blood sample or a dried blood spot on an FTA card during a home visit; results are available in 3 to 4 weeks.
3. Is this test covered by insurance in the UAE?
Yes, we offer direct billing verification; contact our WhatsApp at +971545488731 to confirm your planโs coverage for this genetic test.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: This laboratory fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is handled under strict confidentiality and encryption protocols.
Accreditation: ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Top Clinical Specialists: Consultant Medical Genetics, Clinical Geneticist, Molecular Pathologist.
Clinical & Logistical Metadata
| Test Name | KRT5 Gene Epidermolysis Bullosa Simplex Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 โ 4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full Gene Coverage |
| ICD-10-CM Code | Q81.0, Z13.79, Z15.09 |
| LOINC Code | 81293-1 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE (DNA Labs UAE) |
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