Test Price
2,800 AED✅ Home Collection Available
KRT5 Gene Epidermolysis Bullosa Simplex Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين KRT5 لانحلال البشرة الفقاعي البسيط بتقنية التسلسل الجيني من الجيل التالي في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
الملخص التنفيذي: فحص جيني دقيق لتشخيص مرض انحلال البشرة الفقاعي البسيط المرتبط بطفرة جين KRT5، بدقة تشخيصية تصل إلى 99.9% وفق معايير الآيزو الدولية.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Clinical Overview
The KRT5 gene NGS test screens for pathogenic variants in the KRT5 gene causing Epidermolysis Bullosa Simplex (EBS), a hereditary disorder characterized by mechanical fragility and blistering of the skin following minor trauma. Using Next-Generation Sequencing, this assay covers the entire coding region and splice junctions, enabling precise molecular diagnosis crucial for prognosis, genetic counselling, and targeted management strategies. يوفر هذا الفحص تحليلاً كاملاً لجين KRT5 لتشخيص انحلال البشرة الفقاعي البسيط، وهو مرض وراثي يسبب هشاشة الجلد وظهور الفقاعات بعد التعرض لإصابة طفيفة.
| Feature | Our Test (KRT5 NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next-Generation Sequencing (full gene coverage) | Targeted Sanger (known hotspots only) |
| Diagnostic Sensitivity | >99.9% (including deep intronic variants) | ~70% (may miss novel or deep intronic mutations) |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
| Sample Type | Whole Blood, Extracted DNA, or Dried Blood Spot (FTA Card) | Whole Blood only |
| UAE Compliance | ISO 9001:2015, DHA/MOHAP Standards | Variable |
Physician Insight & Safety Protocol
“Molecular diagnosis for Epidermolysis Bullosa Simplex, while highly precise, must always be correlated with clinical presentation, detailed family pedigree, and immunofluorescence mapping when indicated. A negative NGS result on the KRT5 gene does not exclude other subtypes of EB or novel genetic mechanisms. I encourage patients and families to engage with a certified genetic counsellor before and after testing.” – Dr. PRABHAKAR REDDY, DHA License 61713011
Medication Warning: Do not discontinue any prescribed treatment without explicit consultation with your dermatologist or attending physician. Abrupt cessation of anti-inflammatory or immunosuppressive therapies can trigger disease flare-ups.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Active severe anemia (Hb < 8 g/dL), ongoing anticoagulant therapy that cannot be temporarily held (consult your physician), inability to provide informed consent, intercurrent febrile illness.
- Emergency Red Flags: If you experience sudden, widespread blistering with fever, shortness of breath, difficulty swallowing, or signs of secondary skin infection (pus, increased pain, red streaks), seek immediate emergency care. These symptoms require urgent clinical evaluation.
Patient FAQ & Clinical Guidance
What is the KRT5 gene test, and why is it performed?
This NGS test identifies KRT5 mutations causing Epidermolysis Bullosa Simplex, a genetic skin blistering disorder. It clarifies the diagnosis, inheritance pattern, and guides family planning decisions.
س: ما هو فحص جين KRT5 وما أهميته؟
يكشف فحص جين KRT5 الطفرات المسببة لانحلال البشرة الفقاعي البسيط، ويؤكد التشخيص الوراثي بدقة، مما يساعد في توجيه العلاج وتقديم المشورة الوراثية للعائلة.
How is the sample collected and what is the turnaround time?
A certified phlebotomist collects a small blood sample or a dried blood spot on an FTA card during a home visit; results are available in 3 to 4 weeks.
س: كيف يتم جمع العينة وما مدة النتائج؟
تُسحب عينة دم بسيطة أو بقعة دم جافة على بطاقة FTA خلال زيارة منزلية معتمدة، وتظهر النتائج خلال 3 إلى 4 أسابيع.
Is this test covered by insurance in the UAE?
Yes, we offer direct billing verification; contact our WhatsApp at +971545488731 to confirm your plan’s coverage for this genetic.
س: هل يغطي التأمين هذا الفحص في الإمارات؟
نعم، نتحقق من تغطية التأمين مباشرة؛ اتصل بنا عبر واتساب على +971545488731 لتأكيد تغطية خطة التأمين الخاصة بك.
UAE Regulatory Compliance: This laboratory operates under Federal Decree-Law No. 41 of 2024 (Article 87), adheres to the CDS Law 2026 provisions for minors, and is fully compliant with the UAE Personal Data Protection Law (PDPL). ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Top Clinical Specialists: Dermatologist, Clinical Geneticist, Molecular Pathologist.
2026 ICD-10-CM Codes: Q81.0 (Epidermolysis Bullosa Simplex), Z13.79 (Encounter for other screening for genetic and chromosomal anomalies), Z15.09 (Genetic susceptibility to other disease). LOINC: 81293-1 (KRT5 gene mutations found).
Facility License: 9834453 | Support: +971545488731 | Home Collection: 8 AM – 11 PM daily.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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