Test Price
2,800 AED✅ Home Collection Available
KRT10 Gene Epidermolytic Hyperkeratosis NGS Genetic Test in UAE – 2800 AED
Executive Summary & Core Metrics
- Diagnostic Sensitivity: 99.9% via ISO 9001:2015-validated Next-Generation Sequencing (NGS) with full gene coverage for single-nucleotide variants, insertions, deletions, and copy-number changes.
- Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across Dubai and all Emirates.
- Clinical Oversight: Post-test telephone consultation with a DHA-licensed Consultant Medical Geneticist to interpret results and guide dermatologic management.
- Insurance: Direct coverage verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The KRT10 gene test employs next-generation sequencing (NGS) to detect pathogenic variants associated with epidermolytic hyperkeratosis, a rare autosomal-dominant genodermatosis. This molecular confirmation enables precise diagnosis, guides retinoid and keratolytic therapy decisions, and informs family screening. The assay is performed on peripheral whole blood using an ISO-validated bioinformatics pipeline with a 3–4 week turnaround time.
| Feature | Our Test (NGS) | Closest Alternative (Clinical Diagnosis ± Single-Gene Sanger) |
|---|---|---|
| Diagnostic Precision | Full gene coverage; detects SNVs, indels, CNVs with 99.9% sensitivity | Limited to known hotspots; may miss large deletions or duplications |
| Methodology | Next-Generation Sequencing (NGS) with ISO-validated bioinformatics | Clinical evaluation + targeted Sanger sequencing only |
| Turnaround Time | 3–4 weeks, reported via secure DHA-compliant portal | Varies; often 6–8 weeks for genetic confirmation |
| Regulatory Alignment | DHA-licensed, ISO 9001:2015, UAE PDPL-compliant data handling | May lack UAE-specific data privacy guarantees |
Physician Insight & Safety Protocols
“Genetic testing for epidermolytic hyperkeratosis requires careful clinical correlation with the dermatological phenotype. A negative NGS result does not exclude the diagnosis if clinical features are strongly suggestive; further genetic counselling and possible re-analysis are warranted. All medication adjustments, particularly retinoid or keratolytic agents, must be supervised by the treating dermatologist.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
⚠️ Medication Advisory
Do not alter or discontinue any prescribed medication without consulting your doctor. Abrupt changes in retinoid or keratolytic therapy can trigger severe skin exacerbations and should only be undertaken under direct medical supervision.
Exclusion Criteria & ER Red Flags
- Exclusion: Active systemic infection, blood transfusion within the prior 14 days, or inability to provide informed consent (legal guardian required for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- ER Red Flags: Sudden widespread blistering, fever, or signs of sepsis — seek immediate emergency care. This test is not a substitute for acute dermatologic emergency management.
- Sample Rejection: Clotted or haemolysed blood, insufficient DNA yield, or improper transport conditions.
Patient FAQ & Clinical Guidance
1. What exactly does the KRT10 NGS test detect, and how accurate is it?
This NGS panel sequences the entire KRT10 gene with 99.9% diagnostic sensitivity, identifying single-nucleotide variants, insertions, deletions, and copy-number changes responsible for epidermolytic hyperkeratosis. The assay is validated under ISO 9001:2015 and interpreted by board-certified molecular geneticists to ensure clinical-grade reliability.
2. How should I prepare for the blood sample collection at home?
Maintain normal hydration and follow your regular diet; no fasting is required for this genetic test. Our ISO-certified phlebotomist will visit your home between 8 AM and 11 PM using a temperature-controlled transport kit. Continue all prescribed medications unless your dermatologist advises otherwise.
3. Can children undergo this test, and what legal protections apply in the UAE?
Minors can be tested only with written consent from a legal guardian, in full compliance with Federal Decree-Law No. 4 of 2016 and the UAE Personal Data Protection Law (PDPL). All genetic data is encrypted, stored on DHA-approved servers, and pre-test genetic counselling is mandatory to safeguard the child’s best interests.
UAE Regulatory & Data Privacy Adherence
This test is performed under DHA Facility License No. 1143 at DNA Labs UAE, Dubai Healthcare City. All patient data is handled in strict accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and informed consent protocols follow Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | KRT10 Gene Epidermolytic Hyperkeratosis NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (daily 8 AM – 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) with ISO-validated bioinformatics |
| ICD-10-CM Code | Q80.2 |
| LOINC Code | 21663-7 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians