Test Price
2,800 AED✅ Home Collection Available
ITGB2 Gene Leukocyte Adhesion Deficiency (LAD) Genetic Test in Dubai | AED 2800 | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Cold-Chain Processing & NGS Platform.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Complimentary Telephonic Post-Test Clinical Guidance with a DHA-Licensed Genetic Counsellor.
- Insurance: Direct Billing Verification & Pre-Approval Support via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This NGS-based genetic test examines the entire coding region of the ITGB2 gene to identify pathogenic variants associated with leukocyte adhesion deficiency type 1 (LAD-1), a rare primary immunodeficiency. The test is essential for confirming clinical suspicion, guiding early intervention, and enabling accurate family screening in the UAE.
| Feature | Our NGS Test (LAD-1) | Closest Alternative (Flow Cytometry CD18) |
|---|---|---|
| Precision | 99.9% – detects all ITGB2 variants | ~85% – may miss hypomorphic mutations |
| Methodology | LC‑MS/MS‑validated NGS | Immunophenotyping (flow cytometry) |
| Turnaround | 3–4 weeks | 3–5 days |
| Clinical Utility | Diagnosis, carrier status, pre‑symptomatic | Diagnosis only (if expression absent) |
| Guideline Alignment | ACMG 2023 / DHA Standards | Supplementary |
Physician Insight & Safety Protocols
“As a clinical geneticist, I understand the anxiety surrounding genetic testing for a rare condition like LAD. While this state‑of‑the‑art NGS test provides definitive molecular answers, it must be integrated with your clinical picture and never used in isolation. Rest assured, our team at DNA Labs UAE will guide you through every result – your peace of mind is our top priority.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Important Medical Advisory
Do not discontinue prescribed medication without consulting your doctor. Genetic results are one piece of the diagnostic puzzle and should be interpreted alongside clinical findings and family history.
Patient Safety Exclusion Criteria & ER Red Flags
- Exclusion Criteria: Active systemic infection, recent chemotherapy (<2 weeks), ongoing blood transfusions may interfere with DNA integrity; inform the phlebotomist of any bleeding disorders.
- ER Red Flags: If you experience a fever >38.5 °C, difficulty breathing, or rapidly spreading skin ulcers after sample collection, seek emergency medical care immediately and inform your physician.
Patient FAQ & Clinical Guidance
1. What is the ITGB2 gene test for LAD, and how does it confirm the diagnosis?
This advanced genetic test analyzes the ITGB2 gene to detect mutations causing leukocyte adhesion deficiency type 1 (LAD-1), a severe immune disorder that impairs white blood cell function and leads to life-threatening infections from birth. It provides a definitive molecular diagnosis with 99.9% sensitivity.
2. Why does the test take 3 to 4 weeks, and can it be expedited for an ill infant?
The 3-week turnaround reflects the sophisticated NGS library preparation, deep sequencing, and rigorous variant interpretation by two independent clinical scientists, ensuring 99.9% sensitivity and adherence to DHA quality standards. Expedited processing may be arranged for critically ill neonates; contact our clinical team for coordination.
3. Will my health insurance in the UAE cover the ITGB2 genetic test?
Most UAE insurance providers reimburse this diagnostic genetic test when medically necessary and prescribed by a DHA-licensed specialist. We offer free direct billing verification via WhatsApp at +971 54 548 8731 before booking.
UAE Regulatory & Data Privacy Adherence
This service is conducted under DHA Facility License 1143 at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. All genetic data handling complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. Methodology validated by ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | ITGB2 Gene Leukocyte Adhesion Deficiency (LAD) Genetic Test |
| Price (AED) | AED 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or Buccal Swab / FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) – Full coding region of ITGB2 |
| ICD-10-CM Code | D72.0 |
| LOINC Code | 94710-5 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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