Test Price
2,800 AED✅ Home Collection Available
HADHB Gene Trifunctional Protein Deficiency Genetic Test in UAE | 2,800 AED | Accredited Molecular Diagnostics
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited next-generation sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test clinical guidance for result interpretation by a DHA-licensed Consultant Medical Genetics specialist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Corporate Oversight: Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Test Overview & Methodology
This NGS-based HADHB gene test delivers a comprehensive analysis of the entire coding region to identify pathogenic variants causing mitochondrial trifunctional protein deficiency, a severe fatty acid oxidation disorder affecting the liver, kidneys, and endocrine system. The assay employs next-generation sequencing with copy number variant detection for complete molecular characterization.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Precision | 99.9% Diagnostic Sensitivity (NGS full gene sequencing) | Biochemical enzyme assay / acylcarnitine profile (sensitivity ~80%) |
| Methodology | Next Generation Sequencing (NGS) with CNV detection | Tandem mass spectrometry of blood spots + fibroblast enzyme assay |
| Turnaround Time | 3–4 Weeks | 4–8 Weeks (requires cell culture) |
Physician Insight & Safety Protocols
Clinical Commentary from Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403):
"Patients and families receiving HADHB genetic results must interpret findings in close collaboration with a clinical geneticist or metabolic specialist. A positive result alone does not dictate outcome; comprehensive clinical correlation, dietary management, and regular monitoring are essential for optimal care. Genetic counseling before and after testing remains mandatory."
Advisory Notice on Medication Management
Medication Caution: Do not discontinue any prescribed medication or initiate new therapies based solely on this genetic test result without consulting your supervising physician. Clinical correlation with metabolic specialist guidance is required before any treatment changes.
Safety & Exclusion Criteria
Patient Eligibility & Contraindications
- Exclusion Criteria: Patients currently in an acute metabolic crisis (vomiting, lethargy, hypoglycemia) require immediate emergency care; sample collection must be deferred. This test is not suitable for forensic or legal parentage determination.
- Pre-test Requirements: Mandatory genetic counseling session to draw a detailed pedigree chart of family members affected by HADHB gene mutations. Written informed consent per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Emergency Red Flags: Seek immediate medical attention if the patient exhibits sudden onset of severe vomiting, hypotonia, seizures, or signs of hepatic encephalopathy after sample collection. These may indicate underlying metabolic decompensation.
Patient FAQ & Clinical Guidance
1. What does a positive HADHB genetic result mean for my child or myself?
A positive result confirms the presence of one or two disease-causing variants in the HADHB gene, indicating a diagnosis of mitochondrial trifunctional protein deficiency or carrier status. Clinical severity varies; immediate referral to a metabolic specialist and dietary intervention are critical for management.
2. How should I prepare for sample collection, and is fasting required?
You do not need to fast; a peripheral blood sample or buccal swab will be collected by our DHA-certified mobile phlebotomist during a scheduled home visit. Ensure the mandatory genetic counseling session has been completed before collection.
3. Why do results take 3–4 weeks, and how will I receive them?
The comprehensive NGS workflow—library preparation, sequencing, bioinformatics analysis, and clinical interpretation—requires 3–4 weeks for definitive reporting. Results are delivered via a secure patient portal, followed by a telephonic consultation with our genetics team.
4. Is genetic counseling included in the test service?
Yes, pre-test and post-test genetic counseling with a DHA-licensed Consultant Medical Genetics professional is integrated into the service. This ensures thorough pedigree analysis, informed consent, and result explanation tailored to your family history.
UAE Regulatory & Data Privacy Adherence
Data Protection & Healthcare Compliance Framework
All clinical data and genetic results are processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and safety protocols adhere strictly to Federal Decree-Law No. 4 of 2016 on Medical Liability.
ISO 9001:2015 Certification: INT/EGQ/2509DA/3139 | DHA Facility License: 1143 | Corporate Lab: DNA Labs UAE
Clinical & Logistical Metadata
| Test Name | HADHB Gene Trifunctional Protein Deficiency Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or buccal swab; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next Generation Sequencing (NGS) with CNV detection |
| ICD-10-CM Code | E71.3 (Disorders of fatty-acid oxidation) |
| LOINC Code | 94222-7 (HADHB gene sequencing) |
| DHA Facility License & Laboratory Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians