Test Price
2,800 AED✅ Home Collection Available
GSTZ1 Gene Tyrosinemia Type 1B Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Executive Summary: This test delivers precise genetic sequencing using Next-Generation Sequencing (NGS) to diagnose Tyrosinemia Type 1B caused by GSTZ1 gene mutations, adhering to Dubai Health Authority standards and ensuring 99.9% diagnostic accuracy with full data privacy protection under UAE PDPL.
- ✓Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing (Cert: INT/EGQ/2509DA/3139).
- ✓Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- ✓Clinical Guidance: Telephonic post-test clinical interpretation by a DHA-licensed Consultant Medical Geneticist, ensuring informed decision-making.
- ✓Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The GSTZ1 gene test uses Next-Generation Sequencing (NGS) to detect pathogenic variants responsible for Tyrosinemia Type 1B, a rare inborn error of tyrosine metabolism that can lead to liver and kidney damage if untreated. This test is a critical diagnostic tool for confirming disease, carrier screening, and family risk assessment.
| Feature | Our Test (NGS) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Clinical Precision | Full GSTZ1 gene coverage; 99.9% sensitivity for all clinically relevant variants | Selective exon analysis only; may miss deep intronic or regulatory mutations |
| Methodology | NGS (Illumina® platform) with Sanger confirmation of pathogenic calls | Sanger sequencing of limited coding regions |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
Physician Insight & Safety Protocols
“Genetic testing for Tyrosinemia Type 1B provides families with a definitive molecular diagnosis, enabling early dietary intervention and metabolic management. However, results must always be interpreted in the full clinical context—collaboration with a metabolic specialist is essential before making any treatment decisions.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory on Medication & Dietary Management
⚠️ Important Advisory: Do not discontinue or modify any prescribed treatment, including tyrosine-restricted medical formulas, without direct supervision from your metabolic physician. Abrupt dietary changes may trigger metabolic decompensation.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria & Emergency Red Flags
- •Exclusion Criteria: This test is not indicated for asymptomatic individuals without a confirmed family history of tyrosinemia Type 1B unless recommended by a certified genetic counsellor. Acute intercurrent illness or recent blood transfusion may compromise DNA quality; reschedule collection after full recovery.
- •ER Red Flags: Seek immediate emergency care if the patient develops unexplained severe vomiting, jaundice, unusual bleeding/bruising, cabbage‑like odour, lethargy, or neurological deterioration—these may signal an acute tyrosinemia crisis requiring urgent metabolic support.
Patient FAQ & Clinical Guidance
1. What is the GSTZ1 gene test for Tyrosinemia Type 1B?
The GSTZ1 gene test is a highly accurate genetic analysis that detects disease‑causing mutations linked to Tyrosinemia Type 1B, a treatable metabolic disorder. It uses NGS technology to provide comprehensive coverage of the GSTZ1 gene.
2. Who should consider this genetic test?
Individuals with symptoms suggestive of tyrosinemia, those with a family history of the condition, or couples planning a family where one partner is a known carrier should consider testing. A pre-test genetic counselling session is required to assess appropriateness.
3. How do I prepare for the GSTZ1 gene test?
A pre‑genetic counselling session is essential to document your family pedigree; no fasting or medication changes are required unless directed by your physician. The sample collection is a simple blood draw performed at home or in our facility.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance: This test is conducted under the DHA Facility License Number 1143 at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. All personal data is processed in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. Results are confidential and shared only with the ordering physician and patient.
Quality & Accreditation: ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). Methodology: Next‑Generation Sequencing (NGS) with clinically validated bioinformatics pipeline.
Clinical & Logistical Metadata
| Test Name | GSTZ1 Gene Tyrosinemia Type 1B Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or genomic DNA extracted from blood; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina® platform with Sanger confirmation of pathogenic variants |
| ICD-10-CM Code | E70.21 |
| LOINC Code | 92868-6 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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