Test Price
2,800 AED✅ Home Collection Available
GH1 Gene Growth Hormone Deficiency Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Service Guarantee & Key Metrics
- 99.9% Diagnostic Sensitivity – ISO 9001:2015 accredited NGS analysis with full clinical validation for GH1 pathogenic variants.
- VIP Mobile Phlebotomy & Cold-Chain Home Collection – Temperature-controlled sample transport available daily 8 AM–11 PM, staffed by DHA-licensed nurses.
- Telephonic Post-Test Genetic Counselling – DHA-licensed consultant medical geneticist provides result interpretation and pedigree analysis.
- Direct Insurance Billing Verification – WhatsApp +971 54 548 8731 for real-time eligibility checks.
Test Overview & Methodology
The GH1 Gene Growth Hormone Deficiency Genetic Test is a definitive molecular diagnostic assay that sequences the entire GH1 gene using Next-Generation Sequencing (NGS) with copy number variant (CNV) analysis. It identifies pathogenic variants causing isolated growth hormone deficiency (IGHD), enabling endocrinologists and pediatricians to confirm genetic aetiology, guide hormone replacement therapy, and offer family cascade screening.
Pre-Test Requirements
- Provide a detailed clinical history documenting growth patterns, familial short stature, and prior endocrine evaluations.
- A mandatory genetic counselling session to construct a pedigree chart of family members affected by GH1-related growth hormone deficiency (informed consent required per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Sample collection: Whole blood (EDTA), extracted DNA, or one drop of blood on an FTA card. Cold-chain transport is maintained for all specimens.
- For minors, legal guardian consent is mandatory in accordance with Federal Decree-Law No. 4 of 2016.
- Do not discontinue any prescribed growth hormone or other medication without consulting your physician.
| Feature | Our GH1 NGS Test (Full-Gene) | Alternative Biochemical / Targeted Assay |
|---|---|---|
| Methodology | Full-gene NGS with CNV detection | Sanger sequencing of selected exons; growth hormone stimulation tests |
| Diagnostic Yield | >99% sensitivity for GH1 mutations | ~60–70% (stimulation tests often inconclusive) |
| Turnaround Time | 3–4 Weeks | Days to weeks; mutation analysis may still require NGS |
| Clinical Utility | Definitive genetic diagnosis, family screening, personalised treatment planning | Functional assessment only; genetic aetiology remains unresolved |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403: “A positive GH1 mutation does not always dictate the full clinical phenotype; variability in expression is well-documented. Results must be integrated with auxological measurements and biochemical profiles. This NGS assay is a powerful diagnostic adjunct, but it should never replace a comprehensive endocrine workup. Patients and families should not alter or discontinue hormone therapy solely on the basis of a genetic result without specialist consultation.”
Critical Advisory: Medication Continuity
Do not discontinue or adjust any prescribed medication, including growth hormone therapy, without explicit instruction from your treating endocrinologist or paediatrician. Abrupt cessation may cause adverse metabolic effects and should be avoided.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Individuals unable to provide informed consent due to cognitive impairment or severe psychiatric condition; haemodynamic instability precluding safe phlebotomy.
- ER Red Flags: If after blood collection you experience heavy bleeding, fainting, signs of infection (redness, warmth, pus), or allergic reaction (swelling, difficulty breathing), proceed to the nearest emergency department immediately.
- Results are for clinical diagnostic use; this test is not a substitute for acute medical evaluation. Always follow your physician’s guidance.
Patient FAQ & Clinical Guidance
1. What exactly does the GH1 NGS test detect, and how is it different from a regular growth hormone blood test?
This test sequences the entire GH1 gene at high depth to identify permanent, heritable mutations that cause isolated growth hormone deficiency. Standard growth hormone stimulation tests measure circulating hormone levels but cannot pinpoint the genetic root cause. Our assay provides a definitive molecular diagnosis that informs lifelong management and family counselling.
2. Is a genetic counselling session mandatory before taking this test in the UAE?
Yes. Pre-test genetic counselling is mandatory under UAE medical practice standards and Federal Decree-Law No. 4 of 2016 on Medical Liability. It ensures you understand the implications of genetic testing, allows for pedigree analysis, and secures informed consent. Our consultant medical geneticist Lina Osama Zaki Quteineh conducts these sessions.
3. What does a positive result mean for my child’s growth and development?
A positive result confirms a genetic cause for growth hormone deficiency, enabling targeted hormone replacement therapy and close auxological monitoring. However, phenotypic expression varies; some children may have mild short stature while others require early intervention. Your paediatric endocrinologist will integrate the genetic report with growth charts and biochemical data to tailor the treatment plan.
4. How long does it take to get results, and how will I receive them?
The turnaround time is 3–4 weeks from sample receipt. Results are delivered electronically via our secure patient portal and discussed during a telephonic follow-up with the consultant medical geneticist. A formal PDF report suitable for your medical file is also provided.
5. Does insurance cover the GH1 genetic test, and how do I verify my coverage?
Coverage varies by insurer and policy. You can verify your eligibility by sending a WhatsApp message to +971 54 548 8731 with your insurance details. Our team will confirm any co-pay or pre-authorisation requirements before sample collection.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data are encrypted, access-controlled, and processed exclusively within UAE jurisdiction. Clinical consent and safety procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your privacy and data security are foundational to our service.
Clinical & Logistical Metadata
| Test Name | GH1 Gene Growth Hormone Deficiency Genetic Test (NGS Full-Gene Sequencing + CNV) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA, or FTA Card Blood Spot |
| Methodology Used | Next-Generation Sequencing (NGS) with Copy Number Variant (CNV) Analysis |
| ICD-10-CM Code | E23.0 |
| LOINC Code | 21636-6 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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