Test Price
2,800 AED✅ Home Collection Available
GATA4 Gene Sequencing Test for Testicular Anomalies and Congenital Heart Disease (NGS) in UAE
Executive Summary & Core Metrics
Our GATA4 NGS panel delivers 99.9% diagnostic sensitivity via ISO 9001:2015 accredited processing. Benefit from VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily from 8 AM to 11 PM), cold‑chain transport, and direct post‑test telephonic clinical guidance with a DHA‑licensed genetic counselor. Insurance pre‑approval is streamlined via WhatsApp at +971 54 548 8731. This service fully adheres to UAE Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Test Overview & Methodology
The GATA4 gene encodes a transcription factor critical for heart and testicular development. This next‑generation sequencing test identifies single nucleotide variants, small insertions/deletions, and copy number changes in the entire coding region of GATA4, aiding diagnosis of syndromic or isolated testicular anomalies with or without congenital heart disease. Interpretation follows ACMG guidelines and uses population databases from gnomAD v4.1, ensuring the most current variant classification.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative (Sanger Single‑Gene) |
|---|---|---|
| Technology | NGS with 100x mean depth & full bioinformatic pipeline | Sanger sequencing – limited to pre‑identified mutation |
| Turnaround Time | 3 to 4 weeks | 4 to 6 weeks |
| Variant Detection | Whole‑gene coverage, including deep intronic variants ±2 bp | Only targeted exon – misses novel or unexpected variants |
| Clinical Utility | Comprehensive diagnosis & family screening | Confirmation of known familial mutation |
| Guideline Compliance | ACMG, DHA, and UAE Federal Decree‑Law No. 45 of 2021 & Federal Law No. 2 of 2019 | Variable |
Physician Insight & Safety Protocols
"As a consultant in medical genetics, I understand the anxiety a family faces when confronting a possible genetic disorder. The GATA4 test provides clarity, but results must always be interpreted alongside echocardiogram findings, testicular imaging, and complete family history. A positive result is a starting point for management – not a final verdict – and we are here to guide you through each step." – Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
⚠️ IMPORTANT: Do not discontinue prescribed cardiovascular or hormonal medications without consulting your doctor. This test does not replace ongoing clinical care.
Safety Exclusion Criteria & ER Red Flags
- Exclusion: Patients currently in acute cardiac failure or unstable arrhythmia must postpone elective genetic testing until stabilization.
- Exclusion: Minors require written consent from a legal guardian and pre-test genetic counselling per Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Emergency Red Flag: If you or your child experience sudden chest pain, syncope, or cyanosis, proceed to the nearest emergency department immediately; do not wait for genetic results.
- Emergency Red Flag: Acute scrotal pain or testicular torsion symptoms require urgent urological evaluation.
Patient FAQ & Clinical Guidance
1. What is the GATA4 gene test and who should consider it?
Key Answer: This GATA4 gene test is a next-generation sequencing analysis detecting variants in the GATA4 gene linked to testicular anomalies and heart defects. It is recommended for individuals with a personal or family history of congenital heart disease, undescended testes, or hypospadias. Indications include: recurrent ventricular septal defect, atrial septal defect, tetralogy of Fallot, or unexplained infertility with testicular dysgenesis. Genetic counselling is mandatory before testing to ensure appropriate interpretation and family planning.
2. How is the sample collected and what preparation is needed?
Key Answer: A simple blood draw, extracted DNA specimen, or one drop of blood on an FTA card is adequate for high-quality sequencing. Our mobile phlebotomy team arrives at your home within a 2‑hour window; no fasting is required. A detailed clinical history form and a three‑generation pedigree must be submitted before processing. If you are taking anticoagulants, please inform the team to adjust the collection procedure safely.
3. What do the test results mean for my child and our family planning?
Key Answer: A positive result confirms the presence of a disease‑causing GATA4 variant, explaining the clinical picture and enabling predictive testing for at‑risk relatives. A negative result reduces but does not eliminate the possibility of other genetic or non‑genetic causes. All results are shared in a tele‑consultation with our DHA‑licensed genetic counselor, who will discuss recurrence risk, prenatal options, and recommended surveillance. Post‑support is available in English.
UAE Regulatory & Data Privacy Adherence
This service is delivered under DHA facility license number 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. All genetic data processing complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent adhere to Federal Decree‑Law No. 4 of 2016 on Medical Liability. © 2026 DNA Labs UAE.
Clinical & Logistical Metadata
| Test Name | GATA4 Gene Sequencing Test for Testicular Anomalies and Congenital Heart Disease (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood, extracted DNA, or FTA card |
| Methodology Used | Next-generation sequencing (NGS) of the GATA4 coding region with 100x mean depth |
| ICD-10-CM Code | Z13.79 |
| LOINC Code | 94051-3 |
| DHA Facility License & Laboratory Address Invariants | DHA License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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