Test Price
2,800 AED✅ Home Collection Available
GALE Gene Galactose Epimerase Deficiency Genetic Test – Dubai, UAE | 2800 AED
Executive Summary & Core Metrics
The GALE Gene NGS test delivers definitive molecular confirmation of galactose epimerase deficiency (galactosemia type III) with exceptional analytical accuracy. This assay replaces older enzymatic methods by identifying the exact pathogenic DNA variant, enabling precise carrier detection and informed family planning.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing (NGS with orthogonal LC‑MS/MS confirmation where applicable).
- Premium Logistics: VIP Mobile Phlebotomy and Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Post-test telehealth interpretation and genetic counselling by DHA-licensed Consultant Medical Genetics.
- Insurance Support: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The GALE Gene NGS test comprehensively screens for pathogenic variants in the GALE gene causing galactose epimerase deficiency. This molecular assay provides definitive confirmation and carrier detection with full coding region and intron-exon boundary coverage using Illumina NovaSeq X Plus technology.
| Feature | Our Test (NGS) | Closest Alternative (Enzymatic Assay) |
|---|---|---|
| Diagnostic Precision | >99.9% analytical sensitivity and specificity; identifies exact DNA variant | ~85–90% sensitivity; cannot differentiate variant types |
| Methodology | Next‑Generation Sequencing (Illumina NovaSeq X Plus) with full gene coverage | Colorimetric enzyme activity assay in erythrocytes |
| Turnaround / Speed | 3–4 weeks, inclusive of clinical reporting | 2–4 weeks; often requires secondary DNA confirmation |
Physician Insight & Safety Protocols
“A positive GALE gene variant must always be correlated with clinical presentation and biochemical markers such as galactose‑1‑phosphate and urinary galactitol levels. This test delivers maximum clinical value when embedded in a structured pathway of pre‑ and post‑test genetic counselling, particularly for consanguineous families or those with a history of neonatal metabolic distress.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication and Dietary Precautions
Maintain all prescribed medications and existing dietary galactose restrictions unless explicitly directed otherwise by your supervising physician. Test results must be interpreted within the full clinical context and should not trigger abrupt treatment changes without a follow‑up consultation.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Blood transfusion within 4 weeks may affect germline DNA purity; consult lab prior to collection.
- Exclusion: Severe anaemia (<7 g/dL) or active infection with fever >38.5°C – reschedule home draw.
- Emergency Red Flags (seek immediate medical attention): Acute vomiting, lethargy, jaundice, hypoglycaemia, or sepsis‑like symptoms in a newborn or child – this test is not for acute crisis management.
Patient FAQ & Clinical Guidance
1. What is the GALE gene test used for?
The GALE gene NGS test identifies DNA mutations causing galactose epimerase deficiency, a rare inherited disorder that impairs the body's ability to process galactose. The analysis confirms diagnosis, guides dietary management, and assesses familial risk. It examines the entire coding region of the GALE gene, providing a definitive molecular diagnosis for galactosemia type III, clarifying the exact variant and inheritance pattern essential for personalised treatment and genetic counselling.
2. How should I prepare for the GALE gene blood test?
Preparation requires a pre‑test genetic counselling session to document family history; fasting is not mandatory. Do not alter any medications without explicit physician approval. The home collection team will draw a single blood sample into an EDTA tube or collect a few drops on an FTA card—both methods maintain DNA integrity under strict cold‑chain transport. Continue your usual diet; galactose restriction prior to testing is unnecessary and could mask biochemical clues if performed simultaneously with other assays.
3. When will I receive my GALE genetic test results and what do they mean?
Results are delivered in 3 to 4 weeks through a secure patient portal and include a clinical interpretation that distinguishes between pathogenic mutations, variants of uncertain significance, and benign polymorphisms. A positive pathogenic variant confirms galactose epimerase deficiency; negative findings reduce the likelihood but do not exclude rare deep intronic mutations if clinical suspicion remains high. All reports are reviewed by our DHA‑licensed genetic counsellors, and a complimentary post‑test teleconsultation is provided to explain implications for diet, follow‑up, and family screening.
UAE Regulatory & Data Privacy Adherence
Your Data. Your Rights. Our Commitment.
DNA Labs UAE operates under DHA Facility License Number 1143 and complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access‑controlled, and processed solely for diagnostic purposes. Patient consent procedures follow the standards set by Federal Decree-Law No. 4 of 2016 on Medical Liability. Independent audits and ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) reinforce our commitment to the highest levels of data security and clinical integrity.
Clinical & Logistical Metadata
| Test Name | GALE Gene Sequencing – Galactose Epimerase Deficiency (Galactosemia Type III) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks (21–28 business days) |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Coverage, Illumina NovaSeq X Plus |
| ICD-10-CM Code | E74.29 |
| LOINC Code | 81247-9 |
| DHA Facility License & Laboratory Address | License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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