Test Price
2,800 AED✅ Home Collection Available
FKBP10 Gene Osteogenesis Imperfecta Type XI NGS Genetic Test in Dubai
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM across all UAE emirates.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed genetic counsellors.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test analyzes the entire coding region of the FKBP10 gene to identify pathogenic variants causing osteogenesis imperfecta type XI (OI type XI) – a moderate-to-severe bone fragility disorder often associated with congenital contractures, skin hyperextensibility, and progressive skeletal deformity. Results guide personalized orthopaedic and dermatological management, reproductive risk assessment, and cascade family screening.
| Feature | Our NGS Test (This Package) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity for point mutations and small indels | ~95% sensitivity; large deletions/duplications may be missed |
| Methodology | NGS (Next Generation Sequencing) with CNV analysis | Sanger sequencing of individual amplicons |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks (often as reflex after negative first‑tier) |
| Clinical Utility | Full gene coverage – detects novel and known FKBP10 variants | Targeted analysis limited to known hotspots |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403: “Although the FKBP10 test provides a definitive molecular diagnosis, it must be interpreted in the full clinical context. A negative result does not exclude other bone fragility syndromes, and I strongly recommend in-person genetic counselling before proceeding with cascade testing of at-risk relatives. Never stop prescribed bisphosphonates or calcium/vitamin D supplements without direct medical advice.”
⚠ Do not discontinue any prescribed medication without consulting your doctor.
Exclusion Criteria & Emergency Red Flags
- Patient unable to provide informed consent (or legal guardian for minors, in strict compliance with UAE Child Protection Law).
- Known current febrile illness or acute fracture requiring immediate orthopaedic intervention – sample collection may be deferred.
- Pregnancy is not a contraindication; however, post‑amniocentesis counselling is mandatory if prenatal diagnosis is sought.
Seek emergency care if you experience:
- Sudden, severe bone pain or new deformity.
- Blue‑grey scleral discoloration with visual changes.
- Respiratory distress or chest wall deformity impairing breathing.
- Child with multiple fractures after minimal trauma and suspicion of abuse – ensure proper safeguarding.
* Always call 998 for ambulance in the UAE.
Patient FAQ & Clinical Guidance
1. What is the FKBP10 gene test and who needs it?
The FKBP10 NGS identifies pathogenic variants causing osteogenesis imperfecta type XI and is recommended for individuals with recurrent low‑trauma fractures, progressive bone deformities, or a family history of brittle bone disease refractory to standard therapies.
2. How long will it take to receive my results?
Turnaround time is 3 to 4 weeks from sample receipt at our ISO‑accredited laboratory, enabling timely clinical decision‑making for surgical planning or bisphosphonate therapy initiation.
3. Is a home blood collection service available across the UAE?
Yes, our VIP mobile phlebotomy team covers all seven Emirates from 8 AM to 11 PM, collecting blood or FTA card samples under cold‑chain conditions with full ISO 9001:2015 compliance.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework
All genetic testing and data handling comply with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL)
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Federal Decree-Law No. 4 of 2016 on Medical Liability
- Dubai Health Authority (DHA) standards for laboratory diagnostics
Patient data is encrypted, stored within UAE servers, and accessible only to authorized medical staff. Results are delivered through secure portals.
Clinical & Logistical Metadata
| Test Name | FKBP10 Gene Osteogenesis Imperfecta Type XI NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL in EDTA) or FTA card dried blood spots |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV analysis |
| ICD-10-CM Code | Q78.0 (Osteogenesis imperfecta); Z15.89; Z84.8 |
| LOINC Code | 83019-6 (FKBP10 gene targeted mutation analysis) |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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ISO Accredited
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All reports reviewed by DHA-Certified physicians