Test Price
2,800 AEDโ Home Collection Available
FGF10 Gene LADD Syndrome Genetic Test โ 2,800 AED โ DNA Labs UAE
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Targeted NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Dedicated telephonic post-test genetic counseling and result interpretation by our Consultant Medical Geneticist.
- Insurance Support: Direct Billing Verification available via WhatsApp at +971 54 548 8731.
Executive Summary & Core Metrics
DNA Labs UAE offers the FGF10 Gene LADD Syndrome Genetic Test, a high-precision diagnostic sequencing assay for detecting pathogenic variants associated with Lacrimo-Auriculo-Dento-Digital (LADD) Syndrome. This test is exclusively conducted within our accredited Dubai Healthcare City facility (DHA License: 1143) under the clinical oversight of Consultant Medical Geneticist Lina Osama Zaki Quteineh (DHA ID: 9294403).
Test Overview & Methodology
This advanced test utilizes targeted next-generation sequencing (NGS) to analyze the FGF10 gene for mutations known to cause LADD syndrome. It provides a definitive molecular diagnosis for patients presenting with characteristic dysmorphic features involving the lacrimal, auricular, and dental systems.
| Feature | Our Test (FGF10 Targeted NGS) | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity for FGF10 coding and splice-site variants | ~95% coverage; may miss deep intronic or copy number variants in FGF10 |
| Methodology | Targeted NGS on Illumina NovaSeq X platform, 100x mean depth | Whole Exome Sequencing with variable coverage depth |
| Turnaround Time | 3โ4 Weeks | 6โ8 Weeks |
| Cost | 2,800 AED | 4,500 โ 6,000 AED |
Physician Insight & Safety Protocols
Clinical Perspective from Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA ID: 9294403): โThe FGF10 gene analysis is a targeted diagnostic step and must be interpreted within the broader context of the patientโs full phenotypic features and three-generation family pedigree. A negative sequencing result does not entirely exclude a genetic etiology, and ongoing clinical correlation remains essential for comprehensive patient management.โ
Pre-Test and Post-Test Advisory
This test requires a formal clinical referral from a licensed physician. All results are accompanied by a mandatory telephonic consultation with our genetic counseling team to discuss clinical implications, family risk, and long-term management strategies.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Not indicated for individuals without a clinical suspicion of LADD syndrome or for acute, undiagnosed medical crises.
- Exclusion: This test must not be used as a stand-alone screening tool without pre- and post-test genetic counseling.
- ER Red Flag: Seek immediate emergency care if the patient develops severe developmental regression, recurrent aspiration pneumonia, or acute respiratory distress.
Patient FAQ & Clinical Guidance
1. What is the FGF10 LADD syndrome genetic test used for?
This test identifies pathogenic mutations in the FGF10 gene to confirm a clinical diagnosis of LADD syndrome in patients presenting with characteristic dysmorphic features of the lacrimal, auricular, and dental systems.
2. How accurate is the NGS testing for FGF10 mutations?
With a validated diagnostic sensitivity of 99.9% on the Illumina NovaSeq X platform, our targeted NGS approach ensures near-complete detection of pathogenic variants in the FGF10 coding and splice-site regions.
3. How long does it take to receive my results?
Your comprehensive FGF10 NGS report will be ready within 3 to 4 weeks from the date of sample receipt. Preliminary findings may be available earlier and will be discussed during your follow-up consultation.
4. When is this test clinically warranted?
This test is clinically warranted for individuals with a suspected diagnosis of LADD syndrome based on clinical findings, family history, or unexplained congenital anomalies affecting the face, ears, teeth, or digits.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is anonymized, encrypted, and stored on secure UAE-based servers. Patient consent protocols comply fully with Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring ethical and legal integrity throughout the diagnostic pathway.
Clinical & Logistical Metadata
| Test Name | FGF10 Gene LADD Syndrome Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood or Buccal Swab (Standard Venipuncture โ VIP Mobile Phlebotomy Eligible) |
| Methodology Used | Targeted NGS (Illumina NovaSeq X Platform, 100x Coverage) |
| ICD-10-CM Code | Q87.8 |
| LOINC Code | 82255-5 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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